全文获取类型
收费全文 | 473篇 |
免费 | 14篇 |
专业分类
耳鼻咽喉 | 9篇 |
儿科学 | 43篇 |
妇产科学 | 2篇 |
基础医学 | 89篇 |
口腔科学 | 6篇 |
临床医学 | 43篇 |
内科学 | 88篇 |
皮肤病学 | 10篇 |
神经病学 | 41篇 |
特种医学 | 38篇 |
外科学 | 45篇 |
综合类 | 8篇 |
预防医学 | 22篇 |
眼科学 | 8篇 |
药学 | 18篇 |
肿瘤学 | 17篇 |
出版年
2020年 | 4篇 |
2018年 | 5篇 |
2017年 | 4篇 |
2016年 | 8篇 |
2015年 | 5篇 |
2014年 | 9篇 |
2013年 | 6篇 |
2012年 | 7篇 |
2011年 | 7篇 |
2010年 | 18篇 |
2009年 | 12篇 |
2008年 | 18篇 |
2007年 | 22篇 |
2006年 | 9篇 |
2005年 | 8篇 |
2004年 | 21篇 |
2003年 | 19篇 |
2002年 | 13篇 |
2001年 | 8篇 |
2000年 | 11篇 |
1999年 | 11篇 |
1998年 | 7篇 |
1997年 | 8篇 |
1996年 | 7篇 |
1995年 | 5篇 |
1994年 | 4篇 |
1993年 | 7篇 |
1992年 | 8篇 |
1991年 | 8篇 |
1990年 | 16篇 |
1989年 | 15篇 |
1988年 | 23篇 |
1987年 | 16篇 |
1986年 | 13篇 |
1985年 | 17篇 |
1984年 | 6篇 |
1983年 | 7篇 |
1982年 | 6篇 |
1981年 | 5篇 |
1980年 | 6篇 |
1979年 | 5篇 |
1978年 | 11篇 |
1977年 | 4篇 |
1976年 | 10篇 |
1975年 | 5篇 |
1973年 | 5篇 |
1971年 | 3篇 |
1969年 | 5篇 |
1968年 | 6篇 |
1966年 | 5篇 |
排序方式: 共有487条查询结果,搜索用时 15 毫秒
161.
162.
163.
164.
A 15-month-old girl with celiac disease presented with microcephaly and developmental delay. Head growth resumed during a gluten-free diet. Subsequent gluten ingestion resulted in no head growth, areflexia, and increased celiac antibodies. All resolved with gluten elimination. Poor head growth may precede other clinical manifestations of celiac disease. 相似文献
165.
166.
Ambartsumian N Klingelhöfer J Grigorian M Christensen C Kriajevska M Tulchinsky E Georgiev G Berezin V Bock E Rygaard J Cao R Cao Y Lukanidin E 《Oncogene》2001,20(34):4685-4695
The involvement of Mts1(S100A4), a small Ca(2+)-binding protein in tumor progression and metastasis had been demonstrated. However, the mechanism by which mts1(S100A4) promoted metastasis had not been identified. Here we demonstrated that Mts1(S100A4) had significant stimulatory effect on the angiogenesis. We detected high incidence of hemangiomas--benign tumors of vascular origin in aged transgenic mice ubiquitously expressing the mts1(S100A4) gene. Furthermore, the serum level of the Mts1(S100A4) protein increased with ageing. Tumors developed in Mts1-transgenic mice revealed an enhanced vascular density. We showed that an oligomeric, but not a dimeric form of the Mts1(S100A4) protein was capable of enhancing the endothelial cell motility in vitro and stimulate the corneal neovascularization in vivo. An oligomeric fraction of the protein was detected in the conditioned media as well as in human serum. The data obtained allowed us to conclude that mts1(S100A4) might induce tumor progression via stimulation of angiogenesis. 相似文献
167.
Drexler HG; Brenner MK; Coustan-Smith E; Wickremasinghe RG; Hoffbrand AV 《Blood》1987,70(5):1536-1542
The peripheral blood mononuclear cells from 16 patients with B-chronic lymphocytic leukemia (B-CLL, n = 13), B-prolymphocytic leukemia (B-PLL, n = 2) or hairy cell leukemia (n = 1) were incubated in the presence of the phorbol ester 12-0-tetradecanoylphorbol-13-acetate (TPA) and the calcium ionophore A23187. A synergy between these inducers was found with respect to morphological changes and B cell proliferation and differentiation. A23187 used alone did not activate the cells. B-CLL cells treated with the double stimulus acquired a plasmacytoid morphology, showed significantly higher incorporation of 3H-thymidine and 3H-uridine, and produced significantly higher amounts of monoclonal immunoglobulin compared with the same cells exposed to either of the inducers alone. These results indicate that phorbol ester and calcium ionophore act synergistically on B-CLL cells to induce proliferation and differentiation. B-PLL cells responded more vigorously to the signals provided by TPA and A23187. Previous studies showed that TPA and A23187 can mimic the two physiological second messengers diacylglycerol and inositol trisphosphate in the transduction of signals leading to cell activation, proliferation, and differentiation in normal B cells. The present findings suggest that the capacity of B- CLL and B-PLL cells to differentiate in response to signals of the second messenger pathway is intact. 相似文献
168.
Percutaneous coronary revascularization in elderly patients: impact on functional status and quality of life 总被引:8,自引:0,他引:8
Seto TB Taira DA Berezin R Chauhan MS Cutlip DE Ho KK Kuntz RE Cohen DJ 《Annals of internal medicine》2000,132(12):955-958
BACKGROUND: Percutaneous coronary intervention (PCI) is frequently performed in elderly patients, but little is known about its impact on overall health and quality of life. OBJECTIVE: To examine changes in health-related quality of life among elderly patients after PCI. Design: Observational study. SETTING: 75 U.S. hospitals. PATIENTS: Participants in two clinical trials of PCI. MEASUREMENTS: Health-related quality of life was assessed by using the Medical Outcomes Study Short Form (SF-36) survey and the Seattle Angina Questionnaire at baseline, 6 months, and 1 year. RESULTS: Serial data on health-related quality of life were available for 295 elderly (> or =70 years) and 1150 nonelderly (<70 years) patients. At 6 months, physical health had improved in 51% of elderly patients and mental health had improved in 29%. Cardiovascular-specific health status had improved in 58% to 75% of elderly patients. Improvement did not significantly differ between elderly and non-elderly patients at 6 months or 1 year. CONCLUSIONS: Elderly patients selected for participation in a trial of PCI had substantial improvements in health-related quality of life after PCI that were similar to those in younger patients. 相似文献
169.
170.
R V Afanas'ev V G Zuev G I Berezin V N Sereda A K Zasiad'ko 《Aviakosmicheskaia i ekologicheskaia meditsina》2004,38(4):20-28
Radiation risks from isotope-containing equipment, and ionizing and unused X-ray radiation sources are characterized and relevant normative documents with safety requirements to radiation sources installation, radiation safety of aircraft servicing and repair, hand luggage control and heavy luggage registration, personal protection items, system of radiation monitoring at airlines and aircraft works, and liability for breach of performance guidelines are cited. 相似文献