全文获取类型
收费全文 | 472篇 |
免费 | 14篇 |
专业分类
耳鼻咽喉 | 9篇 |
儿科学 | 43篇 |
妇产科学 | 2篇 |
基础医学 | 89篇 |
口腔科学 | 6篇 |
临床医学 | 43篇 |
内科学 | 87篇 |
皮肤病学 | 10篇 |
神经病学 | 41篇 |
特种医学 | 38篇 |
外科学 | 45篇 |
综合类 | 8篇 |
预防医学 | 22篇 |
眼科学 | 8篇 |
药学 | 18篇 |
肿瘤学 | 17篇 |
出版年
2020年 | 4篇 |
2018年 | 5篇 |
2017年 | 4篇 |
2016年 | 8篇 |
2015年 | 5篇 |
2014年 | 9篇 |
2013年 | 6篇 |
2012年 | 7篇 |
2011年 | 7篇 |
2010年 | 18篇 |
2009年 | 12篇 |
2008年 | 18篇 |
2007年 | 22篇 |
2006年 | 9篇 |
2005年 | 8篇 |
2004年 | 21篇 |
2003年 | 19篇 |
2002年 | 13篇 |
2001年 | 8篇 |
2000年 | 11篇 |
1999年 | 11篇 |
1998年 | 7篇 |
1997年 | 8篇 |
1996年 | 7篇 |
1995年 | 5篇 |
1994年 | 4篇 |
1993年 | 7篇 |
1992年 | 8篇 |
1991年 | 8篇 |
1990年 | 16篇 |
1989年 | 15篇 |
1988年 | 23篇 |
1987年 | 16篇 |
1986年 | 13篇 |
1985年 | 17篇 |
1984年 | 6篇 |
1983年 | 7篇 |
1982年 | 6篇 |
1981年 | 5篇 |
1980年 | 6篇 |
1979年 | 5篇 |
1978年 | 11篇 |
1977年 | 4篇 |
1976年 | 10篇 |
1975年 | 5篇 |
1973年 | 5篇 |
1971年 | 3篇 |
1969年 | 5篇 |
1968年 | 6篇 |
1966年 | 5篇 |
排序方式: 共有486条查询结果,搜索用时 187 毫秒
121.
122.
123.
A Shankar AV Akulwar Y Singh YS Sirohi VRR Chari 《Medical Journal Armed Forces India》2009,65(1):30-32
Background
This observational study was conducted in a small, 45 bed border static hospital, located in a field area, where no blood bank facilities were available. The present study was conducted to elucidate the blood transfusion practices of this hospital. Methods: A retrospective analysis of all blood transfusions performed in this hospital between Dec 2004 and Dec 2006 was carried out. The data collection included blood group patterns, common indications, haemoglobin levels and complications of blood transfusion. Inferences were based on available data and relevant statistical analysis.Result
A total of 246 blood transfusions were administered to 79 recipients during the study period. Only one patient had an Rh negative blood group. The most frequently transfused blood group was A Rh positive. Majority of transfusions were administered to surgical cases and the commonest indication was gunshot wounds with haemorrhagic shock. The mean haemoglobin at admission was 8.93 g/dl. The mean number of blood transfusions per patient was 3.13. No haemolytic or other transfusion reactions occurred in any of the transfusions.Conclusion
This study demonstrates that blood transfusions can be safely administered in field conditions despite constraints of not having a blood bank.Key Words: Blood transfusion practices, Haemoglobin, Anaemia 相似文献124.
The neural cell adhesion molecule (NCAM) belongs to the immunoglobulin (Ig) superfamily and is composed extracellularly of five Ig-like and two fibronectin type III (F3) modules. It plays a pivotal role in neuronal development and synaptic plasticity. NCAM signals via a direct interaction with the fibroblast growth factor receptor (FGFR). A 15-amino-acid long peptide, the FG loop (FGL) peptide, that is derived from the second F3 module of NCAM has been found to activate FGFR1. We here report that the FGL peptide, when administered intranasally to newborn rats, accelerated early postnatal development of coordination skills. In adult animals s.c. administration of FGL resulted in a prolonged retention of social memory. We found that FGL rapidly penetrated into the blood and cerebrospinal fluid after both intranasal and s.c. administration and remained detectable in the fluids for up to 5 hours. 相似文献
125.
T Collin AV Blackburn RH Milner C Gerrand M Ragbir 《Annals of the Royal College of Surgeons of England》2010,92(4):326-329
INTRODUCTION
This is a 7-year retrospective review summarising the North of England Bone and Soft Tissue Tumour Service''s experience of managing 13 cases of groin sarcoma requiring soft tissue flap reconstruction. This study was performed to try to identify where national referral guidelines in sarcoma management had been followed and reasons for any delays. The study also includes outcome data relating to these patients.PATIENTS AND METHODS
A retrospective, case-note review was undertaken using the local sarcoma database to identify approriate patients.RESULTS
In nine patients, national referral guidelines were not followed. This resulted in a mean delay of presentation to the multidisciplinary team of 4.4 months. Ten patients had unplanned excision or exploration of tumours before referral. There were no lower limb amputations. All patients with narrow margins or high grade tumours were referred for radiotherapy. Four patients died; three as a result of distant metastases and one as a result of local recurrence.CONCLUSIONS
Despite delays in referral, treatment by wide excision and plastic surgical reconstruction allowed for local control of these tumours with functional limb salvage. Implementation of National Institute for Health and Clinical Excellence (NICE) guidelines and local strategies could improve the expedient management of these patients. 相似文献126.
We hypothesized that changes in the expression levels of genes in the mammalian target of rapamycin are involved in the hypoxia-induced growth retardation in the brain including hypomyelination. Microarray and proteomic studies showed a 2.3-fold increase in the expression levels of eukaryotic translation initiation factor 4E-binding protein-1 and a 3-fold decrease in the levels of FK506-binding protein-1 in a neonatal model of hypoxia, indicating a signal transduction impairment through mammalian target of rapamycin (mTOR). Analysis of hypoxic brain showed a marked decrease in the phosphorylation levels of 4E-binding protein-1, suggesting a reduction of mTOR activity. These data suggest that suppression of mTOR may be the mechanism underlying hypoxia-induced hypomyelination observed in the developing brain. 相似文献
127.
Kulahin N Li S Hinsby A Kiselyov V Berezin V Bock E 《Molecular and cellular neurosciences》2008,37(3):528-536
The neuronal cell adhesion molecule (CAM) L1 promotes axonal outgrowth, presumably through an interaction with the fibroblast growth factor receptor (FGFR). The present study demonstrates a direct interaction between L1 fibronectin type III (FN3) modules I-V and FGFR1 immunoglobulin (Ig) modules II and III by surface plasmon resonance analysis. Binding of L1 to FGFR1 was enhanced by adenosine 5'-triphosphate (ATP), adenylylmethylenediphosphonate (AMP-PCP), and guanosine-5'-triphosphate (GTP), but not adenosine monophosphate (AMP). The L1-FN3 modules were capable of activating FGFR1, reflected by receptor phosphorylation, and this resulted in the induction of differentiation of primary neurons, reflected by neurite outgrowth. Furthermore, ATP modulated L1-induced neuronal differentiation and FGFR1 phosphorylation through regulation of the L1-FGFR1 interaction. 相似文献
128.
The neural cell adhesion molecule (NCAM) plays a crucial role in neuronal development, synaptic plasticity, and regeneration. NCAM works as "smart glue" that not only mediates cell-cell adhesion but also induces activation of a complex network of intracellular signaling cascades on homophilic or heterophilic binding. Stimulation of NCAM by homophilic interactions induces neuronal differentiation through activation of a number of signaling molecules, including the fibroblast growth factor receptor, non-receptor kinases Fyn and focal adhesion kinase, growth-associated protein-43, the mitogen-activated protein kinase pathway, intracellular Ca(2+), and protein kinases A, C, and G. This review presents and discusses the current knowledge in the area of NCAM signaling with a focus on the events involved in NCAM-mediated neurite outgrowth. 相似文献
129.
Kamil Gotfryd Galina Skladchikova Eugene A Lepekhin Vladimir Berezin Elisabeth Bock Peter S Walmod 《BMC cancer》2010,10(1):383
Background
The anti-epileptic drug valproic acid (VPA) has attracted attention as an anti-cancer agent. 相似文献130.