Tumor of the neck

Neck tumor is always an alarming symptom. Neck tumors are be divided into primary tumors and metastatic tumors. The latter may in turn be divided into tumors which come from a known primary focus and those coming from an unknown primary source. The most commonly found neck tumor takes the form of an enlarged lymph node which may be a primary or a secondary symptom of a disease developing in this area. The diagnostic methods consisted of a otolaryngological examination, laboratory examination, histopathological examination and image examination. In primary neck tumors the treatment proceedings depend on the kind of tumor. The most difficult case, however, is a neck metastasis from an unknown primary focus. In such cases, the most appropriate method of treatment appears to be a radical neck dissection. Combined radiation should be performed in those cases, in which sample tests show cancer infiltration of the node capsule or the presence of cancer plugs in the blood or lymph vessels.     

Anatomic variants and pearls--functional endoscopic sinus surgery

For successful endoscopic sinus surgery. a clear understanding of the anatomy is vital. Knowledge of the anatomic relationships and variations helps surgeons avoid complications. By applying anatomic knowledge with careful surgical technique, one can maximize patient safety. Basic tenets for endoscopic sinus surgery can be applied to a variety of patients with confidence.     

On isolated neck sarcoidosis

The authors present actual opinions concerning etiology, pathogenesis and diagnostics of sarcoidosis with specific evaluation of the role of T lymphocytes and cytokines in formation of sarcoid granulation. Rareness of sarcoidosis in that region and difficulties in neck tumours diagnosis is emphasizing. In solitary sarcoidosis cases it is necessary to take a sarcoid reaction into consideration. It always can go into generalized form. The authors present a case of solitary sarcoidosis of the neck.     

Performance of bilirubin determinations in US laboratories--revisited

BACKGROUND: The diagnosis and management of hyperbilirubinemia in the newborn requires accurate and precise bilirubin determinations. We evaluated the current status of bilirubin measurements in US laboratories by examining data submitted by laboratories participating in the College of American Pathologists (CAP) Neonatal Bilirubin (NB) and Chemistry (C) Surveys. METHODS: We analyzed specimens from the CAP NB and C Surveys by the reference method for total bilirubin in three laboratories. The reference method bilirubin values were compared with bilirubin values reported by Survey participants. RESULTS: The imprecision (CV) for all instruments combined (CAP-All Instruments) ranged from 4.7% to 5.6% at the bilirubin concentrations tested. The CVs of the four most commonly used instruments were smaller, ranging from 1.9% to 4.5%. Differences between bilirubin values by the reference method and mean values from the four most common instruments ranged from -21.6% to 10.9%. When the same specimens from the NB Surveys were used in the C Surveys, the Vitros values were strikingly different from those of the NB Surveys. The use of different methods in the NB and C Surveys coupled with the presence of a nonhuman protein base and ditaurobilirubin (DTB) in the Survey specimens accounted for the discrepant results. CONCLUSIONS: The evaluation of accuracy is impossible from the CAP Surveys because the specimens consist of bovine serum containing a mixture of unconjugated bilirubin and DTB. For the evaluation of accuracy, we recommend that Survey specimens consist of human serum enriched with unconjugated bilirubin.     

Effectiveness of intensive rehabilitation on functional ability and quality of life after first total knee arthroplasty: A single-blind randomized controlled trial

OBJECTIVE: To evaluate the effectiveness of a new intensive functional rehabilitation (IFR) program on functional ability and quality of life (QOL) in persons who underwent a first total knee arthroplasty (TKA). DESIGN: Randomized controlled trial. SETTING: Ambulatory care. PARTICIPANTS: Seventy-seven people with knee osteoarthritis. INTERVENTION: Two months after TKA, subjects were randomly assigned to either a group with IFR (n=38), who received 12 supervised rehabilitation sessions combined with exercises at home between months 2 and 4 after TKA, or to a control group (n=39), who received standard care. All participants were evaluated by a blind evaluator at baseline (2mo after TKA), immediately after IFR (2mo later; POST1), and 2 and 8 months later (POST2 and POST3).Main outcome measures The primary outcome measure with respect to effectiveness was the 6-minute walk test (6MWT) at POST2. Secondary outcome measures were the 6MWT at the other evaluations and the Western Ontario and McMaster Universities Osteoarthritis Index and Medical Outcomes Study 36-Item Short-Form Health Survey. RESULTS: Subjects in the IFR group walked longer distances (range, 23-26m) in 6 minutes at the 3 POST evaluations than subjects in the control group. At POST1 and POST2, they also had less pain, stiffness, and difficulty in performing daily activities. Positive changes in QOL in favor of the IFR were found only at POST2. CONCLUSIONS: The IFR was effective in improving the short-term and mid-term functional ability after uncomplicated primary TKA. The magnitude of the IFR effect on the primary outcome was modest but consistent. More intensive rehabilitation should be promoted in the subacute recovery period after TKA, to optimize functional outcomes in the first year after surgery.     

The Prevention of Early Asthma in Kids study: design, rationale and methods for the Childhood Asthma Research and Education network

Pediatric asthma remains an important public health concern as its prevalence and cost to the health care system is rising. In order to promote innovative research in asthma therapies, the National Heart, Lung and Blood Institute created the Childhood Asthma Research and Education Network in 1999. As its first study, the steering committee of the Childhood Asthma Research and Education Network designed a randomized clinical trial to determine if persistent asthma could be prevented in children at a high risk to develop the disease. This communication presents the design of its first clinical trial, the Prevention of Asthma in Kids (PEAK) trial and the organization of the Childhood Asthma Research and Education Network that developed and implemented this trial. Studies of the natural history of asthma have shown that, in persistent asthma, the initial asthma-like symptoms and loss of lung function occur predominately during the first years of life. Therefore, in the Prevention of Asthma in Kids study, children 2 and 3 years old with a positive asthma predictive index were randomized to twice daily treatment with fluticasone 88 microg or placebo via metered-dose inhaler and Aerochamber for 2 years. The double blind treatment period was followed by a 1-year observational period. Lung function was measured by spirometry and oscillometry technique at 4-month intervals throughout the study. Bronchodilator reversibility and exhaled nitric oxide (ENO) studies were performed at the end of the treatment and observation periods. The primary outcome measure was the number of asthma-free days. Other secondary outcomes included number of exacerbations, use of asthma medications and lung function. These measures were chosen to reflect the progression of the disease from intermittent wheezing to persistent asthma and measurement of the extent of airflow limitation and airway reactivity.     

The effects of occupational exposure to chlorpyrifos on the neurologic examination of central nervous system function: a prospective cohort study

Questions persist about adverse effects such as impaired cognition and attention, incoordination, spasticity, or parkinsonism from chronic, low-level exposures to organophosphate (OP) compounds. In a prospective cohort study, we evaluated chlorpyrifos-manufacturing workers and a referent group on 2 occasions, 1 year apart, to determine whether occupational exposure to chlorpyrifos produced clinically evident central nervous system (CNS) dysfunction. Chlorpyrifos subjects had significantly higher TCP excretion and lower average BuChE activity than referents in a range in which physiological effects on B-esterases exist. Few subjects had neurologic symptoms or signs, and there were no significant group differences in terms of signs at baseline or second examinations. Chronic chlorpyrifos exposure produced no clinical evidence of cortical, pyramidal tract, extrapyramidal, or other CNS dysfunction among chlorpyrifos subjects compared with referents, either at baseline or after 1 year of additional chlorpyrifos exposure.     

The evolution of new business in health care

The increasing size, growth, and complexity of the health care industry would appear to offer ample opportunity for innovation and entrepreneurship. But is entrepreneurship really on the rise in health care? We performed a sequential cross-sectional analysis of new, rapidly growing health care businesses in the Inc. 500 list to answer this question. We found that, while there appears to be increasing numbers of opportunities for new, privately held businesses, this varies widely by category. In particular, health information management appeared to be an example of emerging industry, characterized by increases in the number of businesses, as well as in the rate of growth and the average revenue. In contrast, the insurance industry seems to have transitioned to maturity. This article argues that companies that introduce disruptive innovations into health care, either through information technology, new ancillary services, or more focused services to the elderly, will likely be good areas for investors who follow the health care industry as well as entrepreneurs who are looking for a niche for market entry.     

Reemerging leptospirosis, California

Leptospirosis is a reemerging infectious disease in California. Leptospirosis is the most widespread zoonosis throughout the world, though it is infrequently diagnosed in the continental United States. From 1982 to 2001, most reported California cases occurred in previously healthy young adult white men after recreational exposures to contaminated freshwater. We report five recent cases of human leptospirosis acquired in California, including the first documented common-source outbreak of human leptospirosis acquired in this state, and describe the subsequent environmental investigation. Salient features in the California cases include high fever with uniform renal impairment and mild hepatitis. Because leptospirosis can progress rapidly if untreated, this reemerging infection deserves consideration in febrile patients with a history of recreational freshwater exposure, even in states with a low reported incidence of infection.