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The Karonga Health and Demographic Surveillance System (Karonga HDSS) in northern Malawi currently has a population of more than 35?000 individuals under continuous demographic surveillance since completion of a baseline census (2002-2004). The surveillance system collects data on vital events and migration for individuals and for households. It also provides data on cause-specific mortality obtained by verbal autopsy for all age groups, and estimates rates of disease for specific presentations via linkage to clinical facility data. The Karonga HDSS provides a structure for surveys of socio-economic status, HIV sero-prevalence and incidence, sexual behaviour, fertility intentions and a sampling frame for other studies, as well as evaluating the impact of interventions, such as antiretroviral therapy and vaccination programmes. Uniquely, it relies on a network of village informants to report vital events and household moves, and furthermore is linked to an archive of biological samples and data from population surveys and other studies dating back three decades.  相似文献   
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OBJECTIVE: To evaluate feasibility and effectiveness of a modified exercise program for elderly Korean immigrants (EKIs). Design and sample: Intervention study with EKI residents of a senior house (n = 13, age range 67-86 years, mean age 77 years), recruited through posted fliers and with help from a Korean social worker. INTERVENTION: A Korean-American instructor taught a modified version of an evidence-based exercise program 3 times weekly, 50 min per session, for 12 weeks. Program was evaluated with the Quality Health Outcomes Model. System and client characteristics were taken into consideration because elderly Koreans have their own values and beliefs, which influence their health management behaviors. Evaluation measures included exercise adherence, preintervention and postintervention health outcomes, and satisfaction with the exercise program. Group discussion was used to evaluate satisfaction with the exercise program. RESULTS: Participants showed improved health outcomes on muscle strength, agility/balance, and blood pressure after the exercise program. All participants were satisfied with the exercise program, and participation rates were good (nine participants attended > or = 80% of classes). CONCLUSIONS: The exercise program was feasible for this sample and should be evaluated in a larger population of EKIs and in populations of other ethnic minorities.  相似文献   
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OBJECTIVE

To investigate whether intake of different types of meat is associated with circulating C-reactive protein (CRP) and risk of type 2 diabetes in a prospective cohort study.

RESEARCH DESIGN AND METHODS

Our analysis included 4,366 Dutch participants who did not have diabetes at baseline. During a median follow-up period of 12.4 years, 456 diabetes cases were confirmed. Intake of red meat, processed meat, and poultry was derived from a food frequency questionnaire, and their association with serum high-sensitivity CRP was examined cross-sectionally using linear regression models. Their association with risk of type 2 diabetes was examined using multivariate Cox proportional hazards model, including age, sex, family history of diabetes, and lifestyle and dietary factors.

RESULTS

An increment of 50 g of processed meat was associated with increased CRP concentration (βprocessed meat = 0.12; P = 0.01), whereas intake of red meat and poultry was not. When comparing the highest to the lowest category of meat intake with respect to diabetes incidence, the adjusted relative risks were as follows: for red meat (1.42 [95% CI 1.06–1.91]), for processed meat (1.87 [1.26–2.78]), and for poultry (0.95 [0.74–1.22]). Additional analysis showed that the associations were not affected appreciably after inclusion of CRP into the model. After adjustment for BMI, however, the association for red meat attenuated to 1.18 (0.88–1.59).

CONCLUSIONS

Intake of processed meat is associated with higher risk of type 2 diabetes. It appears unlikely that CRP mediates this association.Since the prevalence of type 2 diabetes has increased rapidly over the last decades, investigations into the effect of dietary and other lifestyle factors on type 2 diabetes have become important (1). One of the dietary factors of interest is meat. Three meta-analyses of prospective cohort studies showed that intake of processed meat is associated with a higher risk of type 2 diabetes (24). For red meat, two of these meta-analyses observed an adverse association (2,4), whereas one did not (3). For poultry, no data from meta-analyses were available. Results from six prospective studies on poultry, however, showed that it is not likely that poultry is associated with a higher risk of type 2 diabetes; three studies observed an inverse association (57), whereas three did not observe an association (810).Intake of red meat and processed meat may increase risk of type 2 diabetes by mechanisms that increase circulating proinflammatory markers. Positive associations have been observed between red meat or processed meat and the proinflammatory blood marker C-reactive protein (CRP), which in turn has been associated with higher risk of type 2 diabetes (11,12,13). The positive association between intake of meat and CRP might be explained by several biological pathways. The binding capacity of iron in the body could be exceeded by the intake of meat, which contains high amounts of heme iron. Free iron can increase oxidative stress, thereby acting as proinflammatory agent (14). Advanced glycation end products (AGEs), which occur naturally in meat and are formed through heat processing (15), may also have proinflammatory actions (16). Thus, the observed positive associations between intake of red meat and processed meat and CRP, and CRP and risk of type 2 diabetes may indicate that CRP mediates the association between intake of meat, especially red and processed meat, and risk of type 2 diabetes. Therefore, we investigated whether intake of red meat, processed meat, and poultry was associated with CRP and risk of type 2 diabetes in a Dutch population.  相似文献   
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Little is known about the perceptions nursing assistants certified (NAC) have related to their occupational health and safety risks and how these perceptions influence the safety precautions taken. The purpose of this study was to describe the perceptions of the occupational health and safety risks perceived by NAC, along with determining the protective mechanisms they used to prevent injury and illness. Ten NAC employed by a skilled nursing facility were interviewed using a semi-structured interview guide. Numerous hazards and protective mechanisms were identified and these were categorized and environmental, physical or cognitive in nature. Based on the NAC perceptions of their occupational hazards, there were a number of areas in which they were ignorant to concepts the administration believed to be readily available. While the facility has a number of health promotion and safety programs already in place, these alone seem inadequate to meet the perceived needs of the NAC. Strategies are needed in three specific areas to address the knowledge deficits and enhance the overall effectiveness of improving the health and safety of the NAC--communication, fostering teamwork, and educational and training opportunities.  相似文献   
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BackgroundThe purposes of this study were to (1) describe physical activity of adult manual wheelchair users as measured by wrist actigraphy and two self-report measures, (2) compare exercisers and nonexercisers on measures of physical activity, and (3) examine the relationships between three activity measures.MethodsFifty manual wheelchair users wore an activity monitor and completed a physical activity record for 7 days. At the completion of this period, a questionnaire that included the Physical Activity Scale for Individuals with Physical Disabilities, stage of exercise question, and demographic and health questions was completed.ResultsMean daily hours spent in bed or asleep was 9.1, mean hours of light intensity activity was 12.5, mean hours of moderate intensity activity was 1.3, and mean hours of strenuous activity was 0.33. Thirty-eight percent did not report any strenuous activity, and 56% reported less than the 150 minutes weekly of moderate or strenuous activity required to meet public health guidelines. There was variability in both self-reported and objectively measured physical activity. Regular exercisers were not significantly different from nonexercisers on objective measures of physical activity. Measured physical movement was weakly correlated with recall of physical activity or exercise.ConclusionMany wheelchair users do not meet public health guidelines for physical activity, but they are not a homogeneous group in intensity and frequency of physical activity. Multiple measurement methods can provide insights into the nature, intensity, and duration of physical activity that is more complex due to variations in abilities and ways of moving.  相似文献   
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