Assessing blood pressure control in patients treated for hypertension: comparing different measurements and targets.

We examined how different methods and definitions of blood pressure affect the achievement of targets in general practice. There was a wide range in the proportion of treated patients achieving the different target levels recommended by the National Institute for Health and Clinical Excellence, British Hypertension Society and the general medical services contract. Among non-diabetic patients this ranged from; 10-37% (average office), 15-39% (standardised nurse measurement), 11-49% (last recorded) and 31-56% (ambulatory blood pressure). Defining targets without a clear definition of how blood pressure should be measured is largely meaningless and ignoring ambulatory blood pressure results in many patients being classified incorrectly as failing to achieve targets.     

Effects of new fish oil derivative on fatty acid phospholipid-membrane pattern in a group of Crohn's disease patients

Fish oil has been recently proposed as a possible effective treatment in inflammatory bowel disease (IBD); however, a lot of annoying side effects (ie, belching, halitosis, diarrhea, etc) affect patient compliance. We carried out a study of patient tolerance in a group of Crohn's disease (CD) patients with a new fish oil derivative consisting of 500-mg capsules of eicosapentaenoic-docosahexaenoic (EPA 40%-DHA 20%), a free fatty acid mixture (Purepa), and we also evaluated its incorporation into phospholipids, both in plasma and in red cell membranes. Five groups of 10 CD patients in remission received nine Purepa capsules daily in four different preparations (A: uncoated, B: coated, pH 5.5; C: coated, pH 5.5, 60 min time release; D: coated, pH 6.9) and 12 × 1-g capsules daily of a triglyceride preparation (Max-EPA, EPA 18%-DHA 10%), respectively. We coated three of the four Purepa preparations in order to delay the release of contents in an attempt to minimize the side effects. After six weeks of treatment, the group taking Purepa capsules, coated, pH 5.5, 60 min time release (group C) showed the best incorporation of EPA and DHA in red blood cell phospholipid membranes (EPA from 0.2 to 4.4%, DHA from 3.7 to 6.3%), and no side effects were registered, whereas in all other groups side effects were experienced in 50% or more of subjects. This new preparation will make it possible to treat patients for long periods.     

Synthesis and polymerization of epoxymethacrylates, 1. Catalysis and kinetics of the addition reaction of methacrylic acid and 2,2-bis[4-(2,3-epoxypropoxy)phenyl]propane

The kinetics of the addition reaction of methacrylic acid (1) and 2,2-bis[4-(2,3-epoxypropoxy)-phenyl]propane catalyzed by tertiary aliphatic amines, aromatic N-heterocycles and quaternary ammonium salts, respectively, was studied in bulk with equimolar amounts of functional groups from room temperature to 120°C. A reaction order of 1,5 with regard to the conversion of epoxy as well as carboxylic groups was observed. This can be explained assuming the formation of an ammonium alkoxide ion pair by the equilibrium reaction of an epoxy group with ammonium carboxylate and the irreversible consecutive reaction of the ion pair with (1) under formation of 2-hydroxyester groups and regeneration of ammonium carboxylate. The reaction rate constants increase linearly with the concentration of the catalyst and increase with increasing basicity of alkylpyridines. The advantage of the aromatic N-heterocyclic catalysts consists in their stability to peroxides which are ingredients of preparations together with the epoxy methacrylate Bis-GMA, e. g. in dental composites and adhesives.     

Understanding the "lucky few": The conundrum of HIV-exposed, seronegative individuals

It has been known for many years that not all individuals who are repeatedly exposed to HIV-1 show evidence of viral replication, seroconvert, and eventually develop disease. Quite apart from those who seroconvert but progress slowly to AIDS (ie, slow progressors, longterm nonprogressors, elite controllers), these rare, exposed seronegatives either resist infection or harbor extremely low levels of virus that may be detected only using ultrasensitive methods (occult infection). The correlates of protection that confer this unique status to a tiny minority of HIV-exposed individuals remain a subject of intense interest, investigation, and controversy, as no single genetic or immunologic parameter has yet been able to fully explain this phenomenon. However, there is general consensus that studying these individuals may provide invaluable information to aid in the design of vaccines and therapeutic approaches. This review describes the major findings on this important topic, with a focus on immunologic studies.