Antibacterial activity of some plant extracts used in folk medicine

In the present work, selected plants were screened for their potential antibacterial activity. For evaluating antibacterial activity, both aqueous and organic solvent methanol was used. The plants screened were Ocimum sanctum, Jatropha gossypifolia, Boerhavia diffusa, Azadirachta indica, Solidago virgaurea, and Commelina benghalensis. The antibacterial activity was assessed against six bacterial strains--Pseudomonas testosteroni, Staphylococcus epidermidis, Klebsiella pneumoniae, Bacillus subtilis, Proteus morganii, Micrococcus flavus. Agar disc diffusion method and Agar ditch diffusion method were used to study the antibacterial activity of all these plants. Ps. testosteroni and K. pneumoniae were the most resistant bacterial strains. A. indica showed strong activity against tested bacterial strains. Therefore, we conclude that A. indica may prove to be a promising agent, and further exploration into this compound should be performed to determine its full therapeutic potential. In addition, its leaf extract can also be used as a lead molecule in combating the diseases caused by the studied bacterial strains.     

Application of stem cell technology for coronary artery disease at the All India Institute of Medical Sciences, New Delhi, India

Stem cell technology is rapidly gaining popularity as a way to improve the prognosis of patients with coronary artery disease and heart failure. In this review, we systematically analyze the basis, methods, and results of stem cell technology for coronary artery disease at the All India Institute of Medical Sciences, New Delhi, India.     

Congestive heart failure in unoperated tetralogy of Fallot: can hypoxia be a cause?

A 10-year-old boy with tetralogy of Fallot and congestive heart failure underwent a right-sided modified Blalock-Taussig anastomosis because of severe biventricular dysfunction and repeated hypercyanotic spells. Postoperatively, there was improvement in systemic oxygen saturation and myocardial function. We postulate that congestive heart failure occurred because of severe myocardial hypoxia and its elimination resulted in markedly improved cardiac performance.     

Lipid and lipoprotein levels of Newfoundland school children

Serum concentrations of total cholesterol, HDL, LDL, and VLDL cholesterol were measured in 1,033 boys and girls age 8-10 years and 14-16 years who were living in two geographically distinct areas on the East and West coast of Newfoundland. The respondents enrolled to this study were school children attending four schools selected at random from all schools in the area. Ninety percent of the invited students participated in the study. The Newfoundland children had higher total cholesterol levels than those reported for children matched for age, sex and race living in the United States. However, their LDL cholesterol levels were found to be similar to those observed in US samples. It was concluded, therefore, that the higher total cholesterol levels of the Newfoundland children were due to their higher HDL cholesterol levels.     

Unidirectional valved patch closure of ventricular septal defect with arterial switch operation in a patient with d-transposition of great arteries with severe pulmonary hypertension

We report our experience with a five-year-old child with d-transposition of great arteries (d-TGA), ventricular septal defect (VSD), and severe pulmonary arterial hypertension (PAH). A fenestrated unidirectional-valved patch was used to close the VSD and a standard arterial witch operation (ASO) was performed. Difficulties in assessment of operability and the choice of procedures in such patients are briefly discussed.