全文获取类型
收费全文 | 81870篇 |
免费 | 7327篇 |
国内免费 | 5467篇 |
专业分类
耳鼻咽喉 | 846篇 |
儿科学 | 884篇 |
妇产科学 | 1224篇 |
基础医学 | 10583篇 |
口腔科学 | 1401篇 |
临床医学 | 10898篇 |
内科学 | 12318篇 |
皮肤病学 | 1026篇 |
神经病学 | 4502篇 |
特种医学 | 3083篇 |
外国民族医学 | 53篇 |
外科学 | 8520篇 |
综合类 | 10780篇 |
现状与发展 | 21篇 |
一般理论 | 22篇 |
预防医学 | 5123篇 |
眼科学 | 2984篇 |
药学 | 8457篇 |
67篇 | |
中国医学 | 4162篇 |
肿瘤学 | 7710篇 |
出版年
2024年 | 259篇 |
2023年 | 1222篇 |
2022年 | 3185篇 |
2021年 | 4107篇 |
2020年 | 3010篇 |
2019年 | 2892篇 |
2018年 | 3071篇 |
2017年 | 2541篇 |
2016年 | 2641篇 |
2015年 | 3799篇 |
2014年 | 4716篇 |
2013年 | 4160篇 |
2012年 | 6174篇 |
2011年 | 6609篇 |
2010年 | 4079篇 |
2009年 | 3083篇 |
2008年 | 4283篇 |
2007年 | 4141篇 |
2006年 | 4248篇 |
2005年 | 4081篇 |
2004年 | 2772篇 |
2003年 | 2536篇 |
2002年 | 2082篇 |
2001年 | 1787篇 |
2000年 | 1772篇 |
1999年 | 2053篇 |
1998年 | 1295篇 |
1997年 | 1265篇 |
1996年 | 956篇 |
1995年 | 904篇 |
1994年 | 765篇 |
1993年 | 481篇 |
1992年 | 593篇 |
1991年 | 497篇 |
1990年 | 471篇 |
1989年 | 411篇 |
1988年 | 370篇 |
1987年 | 300篇 |
1986年 | 248篇 |
1985年 | 210篇 |
1984年 | 130篇 |
1983年 | 86篇 |
1982年 | 42篇 |
1981年 | 51篇 |
1980年 | 29篇 |
1979年 | 63篇 |
1978年 | 22篇 |
1974年 | 27篇 |
1973年 | 18篇 |
1968年 | 16篇 |
排序方式: 共有10000条查询结果,搜索用时 11 毫秒
961.
Yugui Zhang Jiangtao Niu Shujuan Zhang Xinlei Si Tian-Tian Bian Hongwei Wu Donghui Li Yujing Sun Jing Jia Erdan Xin Xingke Yan Yuefeng Li 《Pharmaceutical biology》2022,60(1):1237
ContextHedysari Radix Praeparata Cum Melle (HRPCM) and Astragali Radix Praeparata Cum Melle (ARPCM) are used interchangeably in clinics to treat spleen-qi deficiency (SQD) symptom mainly including gastrointestinal dysfunction and decreased immunity, which has unknown differences in efficacy.ObjectiveTo investigate the differences between HRPCM and ARPCM on intervening gastrointestinal- and immune-function with SQD syndrome.Materials and methodsAfter the SQD model was established, the Sprague–Dawley (SD) rats were randomly divided into nine groups (n = 10): normal; model; Bu-Zhong-Yi-Qi Pills; 18.9, 12.6 and 6.3 g/kg dose groups of HRPCM and ARPCM. Gastrointestinal function including d-xylose, gastrin, amylase vasoactive intestinal peptide, motilin, pepsin, H+/K+-ATPase, Na+/K+-ATPase, sodium-glucose cotransporter 1 (SGLT1), glucose transporter 2 (GLUT2) and immune function including spleen and thymus index, blood routine, interleukin (IL)-2, IL-6, interferon-γ (IFN-γ), tumour necrosis factor-α (TNF-α), immunoglobulin (Ig) M, IgA, IgG and delayed-type hypersensitivity (DTH) were detected. Finally, the efficacy differences were analysed comprehensively by the fuzzy matter-element method.ResultsIn regulating immune, the doses differences in efficacy between HRPCM and ARPCM showed in the high-dose (18.9 g/kg), but there were no differences in the middle- and low- dose (12.6 and 6.3 g/kg); the efficacy differences were primarily reflected in levels of IL-6, IFN-γ, TNF-α and IgM in serum, and the mRNA expression of IL-6 and IFN-γ in the spleen. In regulating gastrointestinal, the efficacy differences were primarily reflected in the levels of D-xylose, MTL, and GAS in serum, and the mRNA and protein expression of SGLT1 and GLUT2 in jejunum and ileum.Discussion and conclusionsHRPCM is more effective than ARPCM on regulating gastrointestinal function and immune function with SQD syndrome. Therefore, we propose that HRPCM should be mainly used to treat SQD syndrome in the future. 相似文献
962.
963.
This study investigated the anti-corrosion performance of commercial amino alcohol migratory corrosion inhibitors (MCIs) on concrete that underwent varying degrees of chloride erosion. Electrochemical impedance spectroscopy (EIS), potentiodynamic polarization (PD), scanning electron microscopy, and energy dispersive spectroscopy (SEM-EDS) analyses were performed to study the anti-corrosion performance and mechanism of the MCIs on the steel bars. The results indicated that the corrosion resistance of the steel bars in concrete was significantly improved by coating with the MCIs, and the earlier the specimens were coated with the MCIs, the higher the anti-corrosion efficiency. The anti-corrosion efficiency was 55.35% when the MCIs coating was applied before chloride erosion; however, the anti-corrosion efficiency decreased to 3.40% when the MCIs coating was applied after the ninth drying–wetting cycle. The improvement in corrosion resistance of the steel bar in concrete coated with MCIs was due to the protective MCIs-molecule film that formed on the steel bar surfaces, and the oxidative dissolution of iron at the anode was effectively inhibited by the MCIs coating. 相似文献
964.
Ke Li Shuping Sun Zhanyou Xue Sufen Chen Chunyang Ju Dongmei Hu Xiaoyu Gao Yanhong Wang Dan Wang Jianjun Chen Li Li Jing Liu Mingjie Zhang Zhihua Jia Xun Han Huanxian Liu Mianwang He Wei Zhao Zihua Gong Shuhua Zhang Xiaoxue Lin Yingyuan Liu Shengshu Wang Shengyuan Yu Zhao Dong 《The journal of headache and pain》2022,23(1)
BackgroundThere have been a few studies regarding the pre-attack symptoms (PAS) and pre-episode symptoms (PES) of cluster headache (CH), but none have been conducted in the Chinese population. The purpose of this study was to identify the prevalence and features of PAS and PES in Chinese patients, as well as to investigate their relationships with pertinent factors.MethodsThe study included patients who visited a tertiary headache center and nine other headache clinics between January 2019 and September 2021. A questionnaire was used to collect general data and information about PAS and PES.ResultsAmong the 327 patients who met the CH criteria (International Classification of Headache Disorders, 3rd edition), 269 (82.3%) patients experienced at least one PAS. The most common PAS were head and facial discomfort (74.4%). Multivariable logistic regression analysis depicted that the number of triggers (OR = 1.798, p = 0.001), and smoking history (OR = 2.067, p = 0.026) were correlated with increased odds of PAS. In total, 68 (20.8%) patients had PES. The most common symptoms were head and facial discomfort (23, 33.8%). Multivariable logistic regression analysis showed that the number of triggers were associated with increased odds of PES (OR = 1.372, p = 0.005).ConclusionsPAS are quite common in CH patients, demonstrating that CH attacks are not comprised of a pain phase alone; investigations of PAS and PES could help researchers better understand the pathophysiology of CH. 相似文献
965.
Emilia A. Korhonen Aino Murtomki Sawan Kumar Jha Andrey Anisimov Anne Pink Yan Zhang Simon Stritt Inam Liaqat Lukas Stanczuk Laura Alderfer Zhiliang Sun Emmi Kapiainen Abhishek Singh Ibrahim Sultan Anni Lantta Veli-Matti Leppnen Lauri Eklund Yulong He Hellmut G. Augustin Kari Vaahtomeri Pipsa Saharinen Taija Mkinen Kari Alitalo 《The Journal of clinical investigation》2022,132(15)
Vascular endothelial growth factor C (VEGF-C) induces lymphangiogenesis via VEGF receptor 3 (VEGFR3), which is encoded by the most frequently mutated gene in human primary lymphedema. Angiopoietins (Angs) and their Tie receptors regulate lymphatic vessel development, and mutations of the ANGPT2 gene were recently found in human primary lymphedema. However, the mechanistic basis of Ang2 activity in lymphangiogenesis is not fully understood. Here, we used gene deletion, blocking Abs, transgene induction, and gene transfer to study how Ang2, its Tie2 receptor, and Tie1 regulate lymphatic vessels. We discovered that VEGF-C–induced Ang2 secretion from lymphatic endothelial cells (LECs) was involved in full Akt activation downstream of phosphoinositide 3 kinase (PI3K). Neonatal deletion of genes encoding the Tie receptors or Ang2 in LECs, or administration of an Ang2-blocking Ab decreased VEGFR3 presentation on LECs and inhibited lymphangiogenesis. A similar effect was observed in LECs upon deletion of the PI3K catalytic p110α subunit or with small-molecule inhibition of a constitutively active PI3K located downstream of Ang2. Deletion of Tie receptors or blockade of Ang2 decreased VEGF-C–induced lymphangiogenesis also in adult mice. Our results reveal an important crosstalk between the VEGF-C and Ang signaling pathways and suggest new avenues for therapeutic manipulation of lymphangiogenesis by targeting Ang2/Tie/PI3K signaling. 相似文献
966.
967.
Wei Hao You-Yang Shi Yue-Nong Qin Chen-Ping Sun Li-Ying Chen Chun-Yu Wu Yi-Jia Bao Sheng Liu 《Medicine》2022,101(30)
Background:To assess the benefits and harmful effects of Chinese herbal medicine (CHM) formulations in preventing anthracyclines (ANT)-induced cardiotoxicity.Method:The Cochrane Library, Pubmed and EMBASE databases were electronically searched for relevant randomized controlled trials (RCTs) published till December 2021 in English or Chinese-language, in addition to manual searches through the reference lists of the selected papers, and the Chinese Conference Papers Database. Data was extracted by 2 investigators independently.Result:Seventeen RCTs reporting 11 different CHMs were included in this meta-analysis. The use of CHM reduced the occurrence of clinical heart failure (RR 0.48, 95% CI 0.39 to 0.60, P < .01) compared to the control group. Data on subclinical heart failure in terms of LVEF values showed that CHM reduced the occurrence of subclinical heart failure (RR 0.47, 95% CI 0.35 to 0.62, P < .01) as well.Conclusion:CHM is an effective and safe cardioprotective intervention that can potentially prevent ANT-induced cardiotoxicity. However, due to the insufficient quality of the included trials, our results should be interpreted with cautious. 相似文献
968.
969.
970.
HPLC法同时测定小儿抗病毒颗粒中黄芩苷和橙皮苷的含量 总被引:1,自引:0,他引:1
目的:建立反相高效液相色谱法同时测定小儿抗病毒颗粒中黄芩苷和橙皮苷含量的方法。方法:色谱柱为Shim—packVP—ODSC18柱(150mm×4.6mm,5μm);流动相为乙腈-水-磷酸(21:79:0.1);流速1.0mE/min;检测波长:283nm。结果:橙皮苷在0.260~0.520μg范嗣内、黄芩苷在0.270—0.720μg范围内与峰面积呈良好的线性关系(橙皮苷r=0.99997、黄芩苷r=0.99996),平均回收率分别为99.37%和101.8%;RSD分别为1.52%和0.63%(n=6)。结论:该方法简便,结果准确,重现性好,可作为该制剂的质量控制方法。 相似文献