全文获取类型
| 收费全文 | 1715210篇 |
| 免费 | 113833篇 |
| 国内免费 | 3750篇 |
专业分类
| 耳鼻咽喉 | 22010篇 |
| 儿科学 | 55877篇 |
| 妇产科学 | 46270篇 |
| 基础医学 | 242248篇 |
| 口腔科学 | 48936篇 |
| 临床医学 | 152515篇 |
| 内科学 | 335470篇 |
| 皮肤病学 | 38731篇 |
| 神经病学 | 131945篇 |
| 特种医学 | 64094篇 |
| 外国民族医学 | 244篇 |
| 外科学 | 258317篇 |
| 综合类 | 39106篇 |
| 现状与发展 | 4篇 |
| 一般理论 | 536篇 |
| 预防医学 | 125136篇 |
| 眼科学 | 40510篇 |
| 药学 | 124460篇 |
| 47篇 | |
| 中国医学 | 4483篇 |
| 肿瘤学 | 101854篇 |
出版年
| 2021年 | 13226篇 |
| 2019年 | 14120篇 |
| 2018年 | 20129篇 |
| 2017年 | 15406篇 |
| 2016年 | 16798篇 |
| 2015年 | 19086篇 |
| 2014年 | 26392篇 |
| 2013年 | 38177篇 |
| 2012年 | 53086篇 |
| 2011年 | 55783篇 |
| 2010年 | 33000篇 |
| 2009年 | 30851篇 |
| 2008年 | 51794篇 |
| 2007年 | 55110篇 |
| 2006年 | 55524篇 |
| 2005年 | 52806篇 |
| 2004年 | 50969篇 |
| 2003年 | 48393篇 |
| 2002年 | 46593篇 |
| 2001年 | 91943篇 |
| 2000年 | 93775篇 |
| 1999年 | 77110篇 |
| 1998年 | 19787篇 |
| 1997年 | 17342篇 |
| 1996年 | 17463篇 |
| 1995年 | 16796篇 |
| 1994年 | 15341篇 |
| 1993年 | 14116篇 |
| 1992年 | 57513篇 |
| 1991年 | 55426篇 |
| 1990年 | 53096篇 |
| 1989年 | 50856篇 |
| 1988年 | 46226篇 |
| 1987年 | 45032篇 |
| 1986年 | 42329篇 |
| 1985年 | 40108篇 |
| 1984年 | 29429篇 |
| 1983年 | 24981篇 |
| 1982年 | 13934篇 |
| 1979年 | 25605篇 |
| 1978年 | 17631篇 |
| 1977年 | 14943篇 |
| 1976年 | 13932篇 |
| 1975年 | 14601篇 |
| 1974年 | 17684篇 |
| 1973年 | 17001篇 |
| 1972年 | 15731篇 |
| 1971年 | 14508篇 |
| 1970年 | 13477篇 |
| 1969年 | 12547篇 |
排序方式： 共有10000条查询结果，搜索用时 15 毫秒
51.
P. Herent B. Schmauch P. Jehanno O. Dehaene C. Saillard C. Balleyguier J. Arfi-Rouche S. Jégou 《Diagnostic and interventional imaging》2019,100(4):219-225
Purpose
The purpose of this study was to assess the potential of a deep learning model to discriminate between benign and malignant breast lesions using magnetic resonance imaging (MRI) and characterize different histological subtypes of breast lesions.Materials and methods
We developed a deep learning model that simultaneously learns to detect lesions and characterize them. We created a lesion-characterization model based on a single two-dimensional T1-weighted fat suppressed MR image obtained after intravenous administration of a gadolinium chelate selected by radiologists. The data included 335 MR images from 335 patients, representing 17 different histological subtypes of breast lesions grouped into four categories (mammary gland, benign lesions, invasive ductal carcinoma and other malignant lesions). Algorithm performance was evaluated on an independent test set of 168 MR images using weighted sums of the area under the curve (AUC) scores.Results
We obtained a cross-validation score of 0.817 weighted average receiver operating characteristic (ROC)-AUC on the training set computed as the mean of three-shuffle three-fold cross-validation. Our model reached a weighted mean AUC of 0.816 on the independent challenge test set.Conclusion
This study shows good performance of a supervised-attention model with deep learning for breast MRI. This method should be validated on a larger and independent cohort. 相似文献52.
V. Jenkins I. Solis-Trapala H. Payne M. Mason L. Fallowfield S. May L. Matthews S. Catt 《Clinical oncology (Royal College of Radiologists (Great Britain))》2019,31(2):99-107
Aims
Delaying progression, ameliorating symptoms and maintaining quality of life (QoL) are primary aims of treatment for metastatic castrate-resistant prostate cancer (mCRPC). Real-world rather than clinical trial data about symptoms and side-effects are sparse. In EXTREQOL, patients' QoL, pain and information needs were recorded during treatment.Material and methods
Men with mCRPC from 20 UK cancer centres starting various systemic mCRPC treatments completed QoL, pain and information needs questionnaires at baseline, 3 and 6 months.Results
In total, 132 patients were recruited. Overall QoL declined significantly by 6 months (Functional Assessment of Cancer Therapy-Prostate [FACT-P] mean = –3.89, 95% confidence interval –6.7 to –1.05, P = 0.007; Trial Outcome Index [TOI] analysis mean = –3.10, 95% confidence interval –5.34 to –0.83, P = 0.007). Those who came off novel therapy and remained on luteinising hormone-releasing hormone agonist therapy alone had worse scores than patients receiving concomitant chemotherapy (Prostate Concerns Subscale mean difference = –4.45, 95% confidence interval –7.06 to –1.83, P = 0.001; TOI mean difference = –5.62, 95% confidence interval –10.97 to –0.26, P = 0.040). At 3 and 6 months, men who reported pain at baseline improved (43%, 40%), but for others pain levels remained the same (45%, 42%) or worsened (13%, 18%). Information regarding supportive care was lacking throughout the period of time on the study.Conclusion
Most mCRPC treated patients experience reduced QoL and inadequate pain control. More help with pain management and better information provision regarding supportive care is warranted. 相似文献53.
54.
Sarah J. Schrauben Haochang Shou Xiaoming Zhang Amanda Hyre Anderson Joseph V. Bonventre Jing Chen Steven Coca Susan L. Furth Jason H. Greenberg Orlando M. Gutierrez Joachim H. Ix James P. Lash Chirag R. Parikh Casey M. Rebholz Venkata Sabbisetti Mark J. Sarnak Michael G. Shlipak Sushrut S. Waikar Paul L. Kimmel Ramachandran S. Vasan Harold I. Feldman Jeffrey R. Schelling 《Journal of the American Society of Nephrology : JASN》2021,32(1):115
55.
Satoru Kudose Dominick Santoriello Hanna Debiec Pietro A. Canetta Andrew S. Bomback M. Barry Stokes Ibrahim Batal Pierre Ronco Vivette D. D’Agati Glen S. Markowitz 《Kidney international》2021,99(1):247-255
- Download : Download high-res image (415KB)
- Download : Download full-size image
56.
57.
58.
59.
60.