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61.
Mitchell Fung MD BMed MTrau Brahman Sivakumar MBBS BSci Med MS MSc FRACS Orth FAOrthA PFET Eric Jiang BSc MAppStat Mayuran Suthersan MBBS MS FRACS FAOrthA Andrew Wines MBBS FRACS Rajat Mittal BSc MBBS MMed MS PhD FRACS FAOrthA Michael Symes BAppSc Physio MBBS FRACS FAOrthA MPH 《ANZ journal of surgery》2023,93(5):1214-1219
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Relationship‐based approaches in early childhood intervention: Are these applicable to paediatric occupational therapy under the NDIS? 下载免费PDF全文
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Brittany C. McGill PhD MPsych Claire E. Wakefield PhD MPH Katherine M. Tucker MD Rebecca A. Daly MAP Mark W. Donoghoe PhD Janine Vetsch PhD Meera Warby MGC Noemi A. Fuentes-Bolanos MD PhD Kristine Barlow-Stewart PhD Judy Kirk MD Eliza Courtney MGC Tracey A. O’Brien MD MBA MHL Glenn M. Marshall MD Mark Pinese PhD Mark J. Cowley PhD Vanessa Tyrrell BAppSc MBA FHGSA ARCPA Rebecca J. Deyell MD MHSc David S. Ziegler MBBS MD Kate Hetherington MPsych PhD 《Cancer》2023,129(22):3620-3632
Background
Germline genome sequencing in childhood cancer precision medicine trials may reveal pathogenic or likely pathogenic variants in cancer predisposition genes in more than 10% of children. These findings can have implications for diagnosis, treatment, and the child’s and family’s future cancer risk. Understanding parents’ perspectives of germline genome sequencing is critical to successful clinical implementation.Methods
A total of 182 parents of 144 children (<18 years of age) with poor-prognosis cancers enrolled in the Precision Medicine for Children with Cancer trial completed a questionnaire at enrollment and after the return of their child’s results, including clinically relevant germline findings (received by 13% of parents). Parents’ expectations of germline genome sequencing, return of results preferences, and recall of results received were assessed. Forty-five parents (of 43 children) were interviewed in depth.Results
At trial enrollment, most parents (63%) believed it was at least “somewhat likely” that their child would receive a clinically relevant germline finding. Almost all expressed a preference to receive a broad range of germline genomic findings, including variants of uncertain significance (88%). Some (29%) inaccurately recalled receiving a clinically relevant germline finding. Qualitatively, parents expressed confusion and uncertainty after the return of their child’s genome sequencing results by their child’s clinician.Conclusions
Many parents of children with poor-prognosis childhood cancer enrolled in a precision medicine trial expect their child may have an underlying cancer predisposition syndrome. They wish to receive a wide scope of information from germline genome sequencing but may feel confused by the reporting of trial results. 相似文献67.
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Carl H. Vanlaar BAppSc Jennifer K. Peat PhD Guy B. Marks PhD FRACP Janet Rimmer MD FRACP Euan R. Tovey PhD 《The Journal of allergy and clinical immunology》2000,105(6)
Background: House dust mite allergen levels in humid coastal regions of Australia are high, particularly in beds. Because high allergen levels in beds are associated with more severe asthma, reduction of levels may be important for asthma control. Objective: We tested the effectiveness of an acaricidal treatment of bedding in combination with occlusive mattress and pillow encasings in reducing allergen levels in children’s beds in a community setting. Methods: A total of 14 beds of children were selected for the active intervention. In each home the bed of a sibling of nearest age was selected as the control. Dust was vacuumed from beds by using a standard protocol, and Der p 1 levels were measured by using ELISA. Adjacent settling dust was collected by using opened Petri dishes. The intervention consisted of encasing mattresses and pillows in occlusive covers and washing all bedding with Acaril, an acaricidal additive. The acaricidal wash was repeated twice in 7 households at 2-month intervals. Control beds were not treated. Results: The mean Der p 1 concentration at baseline was 27.9 μg/g in the active beds and 18.1 μg/g in the control beds. At 4 days after intervention, Der p 1 decreased to 3.2 μg/g and 15.7 μg/g in active and control beds, respectively. The average difference (active minus control) over the first 8-week cycle was 78.5% (P < .0001), and the difference over 3 washing cycles was 125.1% (P < .05). The mean rate of settling Der p 1 adjacent to the actively treated beds decreased from 24.4 ng·m–2·d–1 at baseline to 10.0 ng·m–2·d–1 after intervention (P < .01). Conclusion: A substantial reduction in Der p 1 levels in beds and in airborne dust in a humid region with naturally high house dust mite allergen levels can be achieved and sustained in a community setting with use of occlusive covers and a rigorous washing routine. (J Allergy Clin Immunol 2000;105: 1130-3.) 相似文献
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Evaluation of training nurses to perform semi‐automated three‐dimensional left ventricular ejection fraction using a customised workstation‐based training protocol 下载免费PDF全文