全文获取类型
收费全文 | 33718篇 |
免费 | 1671篇 |
国内免费 | 178篇 |
专业分类
耳鼻咽喉 | 384篇 |
儿科学 | 614篇 |
妇产科学 | 331篇 |
基础医学 | 4367篇 |
口腔科学 | 963篇 |
临床医学 | 2443篇 |
内科学 | 8203篇 |
皮肤病学 | 625篇 |
神经病学 | 2635篇 |
特种医学 | 1315篇 |
外科学 | 5289篇 |
综合类 | 211篇 |
一般理论 | 3篇 |
预防医学 | 1301篇 |
眼科学 | 507篇 |
药学 | 2844篇 |
中国医学 | 73篇 |
肿瘤学 | 3459篇 |
出版年
2023年 | 199篇 |
2022年 | 393篇 |
2021年 | 669篇 |
2020年 | 325篇 |
2019年 | 478篇 |
2018年 | 607篇 |
2017年 | 487篇 |
2016年 | 591篇 |
2015年 | 613篇 |
2014年 | 801篇 |
2013年 | 1001篇 |
2012年 | 1468篇 |
2011年 | 1581篇 |
2010年 | 900篇 |
2009年 | 781篇 |
2008年 | 1328篇 |
2007年 | 1394篇 |
2006年 | 1380篇 |
2005年 | 1499篇 |
2004年 | 1412篇 |
2003年 | 1374篇 |
2002年 | 1412篇 |
2001年 | 1235篇 |
2000年 | 1377篇 |
1999年 | 1202篇 |
1998年 | 413篇 |
1997年 | 306篇 |
1996年 | 312篇 |
1995年 | 270篇 |
1994年 | 258篇 |
1993年 | 252篇 |
1992年 | 808篇 |
1991年 | 721篇 |
1990年 | 733篇 |
1989年 | 783篇 |
1988年 | 713篇 |
1987年 | 639篇 |
1986年 | 608篇 |
1985年 | 572篇 |
1984年 | 442篇 |
1983年 | 331篇 |
1982年 | 188篇 |
1980年 | 161篇 |
1979年 | 284篇 |
1978年 | 226篇 |
1977年 | 172篇 |
1974年 | 166篇 |
1973年 | 152篇 |
1971年 | 154篇 |
1969年 | 172篇 |
排序方式: 共有10000条查询结果,搜索用时 0 毫秒
11.
12.
13.
14.
N Watanabe Y Niitsu H Umeno H Kuriyama H Neda N Yamauchi M Maeda I Urushizaki 《Gan to kagaku ryoho. Cancer & chemotherapy》1987,14(12):3337-3343
Effects of human recombinant TNF on the tumor blood vessels and on the thrombus formation were investigated in relation to its mode of antitumor action against Meth-A sarcoma transplanted in BALB/c mice. The extent of the blood vessel lesion was evaluated by using transparent chamber placed in the mouse skin. Bleeding, hyperemia and congestion were observed at 1-2h, 4-6h and 24h after TNF (1 X 10(4)U/mouse) administration, respectively. In contrast, no histological changes in the normal blood vessels were observed microscopically following TNF injection. Thrombus formation was evoked in the tumor vessels 4h after TNF injection. However, when thrombus formation was prevented by heparin, no difference was observed among antitumor action of TNF against Meth-A fibrosarcoma necrotic response and the rate of complete cure. These results suggest that the direct effects of TNF causing lesions in the tumor blood vessels plays an important role in its antitumor action. 相似文献
15.
16.
S Watanabe K Nakano H Misumi M Yoshikai M Endo A Hashimoto H Koyanagi 《Nihon Geka Gakkai zasshi》1989,90(9):1513-1516
St. Jude Medical valve replacement was performed in 1,039 patients; 320 had aortic (AVR), 543 mitral (MVR), and 176 had double valve replacement (DVR). There were 44(4.2%) early deaths. Follow-up extended in 995 patients from 10 to 130 months, with a cumulative period of 2,730 patients-years. The overall survival rates of AVR, MVR, and DVR patients at 10 years were 60.5%, 89.6%, 90.3% respectively. The linearized incidences of valve thrombosis, thromboembolism, anticoagulation-related hemorrhage, prosthetic valve endocarditis, and significant hemolysis were as follows: 0.11%/pt-yr, 1.33%/pt-yr, 0.04%/pt-yr, 0.18%/pt-yr, and 0.11%/pt-yr, respectively. There were no structural failure after 10 years follow-up. Reoperation (explant and re-replacement or suture repair) was required in 10 patients. Seven of them had periprosthetic leakage, 2 had valve thrombosis, and one underwent reoperation because of a technical error. Actuarially over 98% of patients were free of valve-related mortality at 10 years. St. Jude Medical valve is an excellent alternative for use in the surgical treatment of valvular heart disease. 相似文献
17.
Daisuke Kubota Takanori Kanai Fumiro Yui Tomoko Matsumoto Takahiro Kawamura Yasuhiro Itsui Eriko Okada Seishin Chin Shinya Ooka Masakazu Nagahori Kiichiro Tsuchiya Akihiro Araki Naoya Sakamoto Tatsuya Miyata Mamoru Watanabe 《Nihon Shokakibyo Gakkai zasshi》2007,104(1):42-46
A 44-year-old women developed marked myopathy one year earlier, when she was treated with intravenous prednisolone for acute severe exacerbation of ulcerative colitis. When she was admitted to our hospital for another severe exacerbation, intravenous cyclosporine A was administered as monotherapy because she could not tolerate corticosteroid. The treatment was successful and she obtained complete remission. Cyclosporine A monotherapy is considered to be a valuable alternative to proctocolectomy for severe ulcerative colitis patients who cannot tolerate corticosteroid. 相似文献
18.
Yuko Kamio Yurika Saito Naoki Utoguchi Masuo Kondoh Naoya Koizumi Makiko Fujii Yoshiteru Watanabe 《Journal of controlled release》2005,102(3):563-568
Some physiological substances, including acetylcholine and nitric oxide, are useful candidates for stimulation of intestinal absorption of drugs. In the present study, we elucidated the ability of epinephrine (Epi) to stimulate the intestinal absorption of drugs. We evaluated the ability of Epi to enhance absorption of macromolecules using dextran (Mw 4000 Da), which is poorly absorbed from the intestine, as a model compound in situ in a closed loop of the rat jejunum. Treatment of the jejunum with Epi resulted in significant increase in absorption of dextran in a dose-dependent fashion. The area under the curve (AUC) from 0 to 4 h in the Epi-treated jejunum was 13-fold higher than that in the vehicle-treated jejunum. The absorption-enhancing activity of Epi was 40-fold higher than that of caprate, a clinically used absorption-enhancer of drugs. In the experimental conditions used in this study, histological injury of the mucosa and perturbation of the mucosal membrane were not observed in the Epi-treated jejunum. Treatment with an antagonist of alpha-adrenergic receptors attenuated the stimulation of intestinal absorption by Epi, and treatment with an agonist of alpha-adrenergic receptors resulted in enhancement of intestinal absorption. While an antagonist of beta-adrenergic receptors enhanced the absorption-enhancing effect of Epi, an agonist of beta-adrenergic receptors stimulated intestinal absorption. These results indicate that stimulation of adrenergic receptors may be a novel strategy for intestinal absorption of drugs. 相似文献
19.
Augmentation and subsequent attenuation of Ca2+ current due to lipid peroxidation of the membrane caused by t-butyl hydroperoxide in the rabbit sinoatrial node. 总被引:2,自引:1,他引:1 下载免费PDF全文
N. Sato M. Nishimura H. Tanaka N. Homma Y. Watanabe 《British journal of pharmacology》1989,98(3):721-723
Cellular electrophysiological effects of membrane lipid peroxidation by t-butyl hydroperoxide (TBH) were studied in the rabbit sinoatrial (SA) node. Superfusion for 1-5 min with 300 microM TBH caused an initial increase and subsequent decrease in the spontaneous firing frequency of the SA node. Voltage clamp experiments revealed that TBH initially enhanced but later blocked the Ca2+ current. Thus, membrane lipid peroxidation appears to accelerate and then suppress physiological automaticity by causing biphasic changes in the Ca2+ current. 相似文献
20.