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981.
982.
Successful multitarget therapy using prednisolone,mizoribine and tacrolimus for Henoch–Schönlein purpura nephritis in children
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983.
984.
Hayato Yamazaki Susumu Isogai Tetsushi Sakurai Kenji Nagasaka 《Modern rheumatology / the Japan Rheumatism Association》2010,20(5):518-521
A 64-year-old woman with rheumatoid arthritis (RA) began to complain of recurrent non-productive cough 5 months after starting
adalimumab. The chest radiograph and high-resolution computed tomographic findings revealed diffuse ground-glass attenuation.
Her clinical course suggested that interstitial pneumonia (IP) may have been induced by adalimumab, and she was successfully
treated with a medium dose of corticosteroid. This case indicates that adalimumab-associated IP should be considered if a
RA patient develops non-productive cough following adalimumab therapy. 相似文献
985.
Naohisa Uchimura Atsushi Kamijo Hiroo Kuwahara Makoto Uchiyama Tetsuo Shimizu Shigeru Chiba Yuichi Inoue 《Sleep medicine》2012,13(10):1247-1253
ObjectivesTo evaluate the efficacy and dose–response effect of eszopiclone on sleep latency and sleep maintenance in Japanese patients with primary insomnia.MethodsIn this randomized, double-blind, five-way crossover study, 72 patients received placebo, eszopiclone 1 mg, 2 mg, and 3 mg, and zolpidem 10 mg in random order for two consecutive nights with a washout period between treatments. Objective sleep measures from polysomnography (PSG) and subjective patient reports were collected.ResultsAll active treatments produced significant improvement in objective and subjective sleep latency compared with placebo (P < 0.05 for all comparisons); linear dose–response relationships were observed for eszopiclone. PSG-determined wake time after sleep onset (WASO), sleep efficiency, and number of awakenings (NA), and patient-reported measures of WASO, NA, sleep quality, sleep depth, and daytime functioning significantly improved following treatment with eszopiclone 2 mg and 3 mg and zolpidem 10 mg versus placebo (P < 0.05). Eszopiclone at all doses increased total sleep time and stage 2 sleep time (P < 0.001 for both comparisons), but did not alter REM or slow-wave sleep. Eszopiclone was generally well tolerated; the most frequently reported adverse event was mild dysgeusia.ConclusionsIn Japanese patients with primary insomnia, eszopiclone 2 mg and 3 mg significantly improved PSG-determined and patient-reported sleep latency and sleep maintenance relative to placebo. 相似文献
986.
987.
Perioperative Oral Administration of Cystine and Theanine Enhances Recovery After Distal Gastrectomy
Tomohiro Miyachi MD Takashi Tsuchiya MD PhD Atsushi Oyama MD PhD Takahiro Tsuchiya MD Naomi Abe RD Atsuko Sato RD Yasumasa Chiba MSc Shigekazu Kurihara PhD Tetsuro Shibakusa PhD Takashi Mikami BVSc 《JPEN. Journal of parenteral and enteral nutrition》2013,37(3):384-391
Background: It has been reported that cystine and theanine, amino acids related to glutathione synthesis, have immunomodulatory effects, such as suppressing inflammation after strenuous exercise. In this study, we examined the effects of oral administration of cystine and theanine during the perioperative period as a pilot study. Methods: Forty‐three cases of distal gastrectomy for cancer conducted in our department were assigned to the cystine and theanine group (CT group) or to the placebo control group (P group), and a randomized, single‐blind, parallel‐group study was then performed. Cystine (700 mg) and theanine (280 mg) or a placebo was administered to participants for 10 continuous days (4 days before to 5 days after surgery). Changes in pre‐ and postoperative interleukin (IL)–6, C‐reactive protein (CRP), albumin, white blood cell (WBC) count, neutrophil count, total lymphocyte count, resting energy expenditure (REE), and body temperature were compared and examined. Results: Ten patients were excluded, leaving 33 patients in the study. The CT group had significantly lower IL‐6 values (postoperative day [POD] 4), CRP levels (POD 7), neutrophil counts (POD 4), and body temperatures (POD 5) than the P group (P < .05). In addition, REE in the P group peaked on day 1 (1.14 ± 0.16 [pre‐ and postoperative ratio]), whereas the CT group did not show any increase on POD 1 (0.99 ± 0.21, P < .05 vs P group). Conclusions: This study suggests that oral administration of cystine and theanine during the perioperative period may alleviate postgastrectomy inflammation and promote recovery after surgery. 相似文献
988.
Yasuyo Okada Jun-ichi Nishikawa Masanori Semma Atsushi Ichikawa 《Biochemical pharmacology》2011,(7):2296
We previously demonstrated that prostaglandin (PG) E2 stimulates adhesion of mastocytoma P-815 cells (P-815 cells) to the Arg-Gly-Asp (RGD)-enriched matrix via the PGE2 receptor subtype EP4 [Hatae N, Kita A, Tanaka S, Sugimoto Y, Ichikawa A. Induction of adherent activity in mastocytoma P-815 cells by the cooperation of two prostaglandin E2 receptor subtypes, EP3 and EP4. J Biol Chem 2003;278:17977–81]. Here we investigated the role of various integrin subtypes in the induction of adherent activity in PGE2-stimulated P-815 cells. FACS analysis showed that P-815 cells express high levels of integrin α4, α5, β1 and β2 subunits and moderate levels of integrin αIIb, αv, β3 and β7 subunits. When treated with PGE2, the EP4 agonist ONO-AE1-329 or the cell permeable cAMP analogue, 8-Br-cAMP, P-815 cells showed markedly increased cell surface expression of integrin αIIb, αv and β3 subunits, and these expressions were significantly reduced by addition of the protein synthesis inhibitor cycloheximide. Along with increased cell surface expression, mRNA and protein levels of the integrin β3 subunit, but not of integrin αIIb and αv subunits, were simultaneously elevated. On the other hand, adhesion of P-815 cells in response to PGE2 or 8-Br-cAMP was abolished by antibodies specific for integrin αv and β3 subunits, but not by antibodies for integrin α4, α5, β1, β2 and β7 subunits. Moreover, treatment with tirofiban, an integrin αIIbβ3 antagonist, or eptifibatide, an integrin αvβ3/αIIbβ3 antagonist resulted in a decrease in adhesion of P-815 cells in response to PGE2 or 8-Br-cAMP. These results suggest that de novo synthesis of the integrin β3 subunit plays a pivotal role in PGE2-induced adhesion of P-815 cells to the RGD-enriched matrix through EP4-mediated cAMP signaling. 相似文献
989.
Introduction The immune and nervous system have various common features in the functional characteristics. Both have an intricate network
of synaptic connections and an exquisite communication system that enables intercellular signal transduction. They also share
a number of messenger molecules such as cytokines and chemical mediators.
Discussion Semaphorins, well-defined axonal guidance molecules in the nervous system, also play critical roles in immune regulation.
Various types of semaphorins, including secreted, transmembrane, truncated, and glycosylphosphatidylinositol-anchored forms,
function during immune responses. However, some semaphorins utilize receptors in the immune system that are distinct from
receptors in the nervous system.
Conclusion This review presents a current overview of ‘immune semaphorins’ and their receptors, providing insight into the pleiotropic
activity of this protein family. 相似文献
990.
Yoshinobu Okabe Kotaro Kuwaki Hiroshi Kawano Ryohei Kaji Gen Sugiyama Yusuke Ishida Makiko Yasumoto Yoshiki Naito Atsushi Toyonaga Osamu Tsuruta Michio Sata 《Digestive endoscopy》2010,22(4):319-321
A 75‐year‐old man who underwent choledochojejunostomy for gallstones 30 years ago was hospitalized for general malaise. Abdominal computed tomography revealed marked dilation of the intrahepatic bile duct in the right lobe and an image of a hypervascular tumor. Endoscopic retrograde cholangiography using double‐balloon enteroscopy (DBE) showed a filling defect that was localized to the right hepatic bile duct. Furthermore, the scope was able to readily pass through the anastomosed site of the choledochojejunostomy and, therefore, we observed the interior of the bile duct using the same scope. We obtained an image showing a whitish, papillary‐like tumor, and a biopsy of the tumor rendered the pathology of intraductal papillary mucinous carcinoma. Direct cholangioscopy using DBE is a useful diagnostic tool, particularly in patients with a past history of choledochojejunostomy. 相似文献