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排序方式: 共有302条查询结果,搜索用时 15 毫秒
21.
VG Osnabrück 《MedR Medizinrecht》2000,18(10):488-492
Ohne Zusammenfassung 相似文献
22.
WH Belloso LC Orellana B Grinsztejn JS Madero A La Rosa VG Veloso J Sanchez R Ismerio Moreira B Crabtree‐Ramirez O Garcia Messina MB Lasala J Peinado MH Losso 《HIV medicine》2010,11(9):554-564
Objective
Acquired immune deficiency appears to be associated with serious non‐AIDS (SNA)‐defining conditions such as cardiovascular disease, liver and renal insufficiency and non‐AIDS‐related malignancies. We analysed the incidence of, and factors associated with, several SNA events in the LATINA retrospective cohort.Materials and methods
Cases of SNA events were recorded among cohort patients. Three controls were selected for each case from cohort members at risk. Conditional logistic models were fitted to estimate the effect of traditional risk factors as well as HIV‐associated factors on non‐AIDS‐defining conditions.Results
Among 6007 patients in follow‐up, 130 had an SNA event (0.86 events/100 person‐years of follow‐up) and were defined as cases (40 with cardiovascular events, 54 with serious liver failure, 35 with non‐AIDS‐defining malignancies and two with renal insufficiency). Risk factors such as diabetes, hepatitis B and C virus coinfections and alcohol abuse showed an association with events, as expected. The last recorded CD4 T‐cell count prior to index date (P=0.0056, with an average difference of more than 100 cells/μL) and area under the CD4 cell curve in the year previous to index date (P=0.0081) were significantly lower in cases than in controls. CD4 cell count at index date was significantly associated with the outcome after adjusting for risk factors.Conclusions
The incidence and type of SNA events found in this Latin American cohort are similar to those reported in other regions. We found a significant association between immune deficiency and the risk of SNA events, even in patients under antiretroviral treatment. 相似文献23.
Karagiannis A Mikhailidis DP Athyros VG Kakafika AI Tziomalos K Liberopoulos EN Florentin M Elisaf M 《Expert opinion on therapeutic targets》2007,11(2):191-205
The metabolic syndrome (MetS) is a strong predictor of cardiovascular morbidity and mortality, as well as new Type 2 diabetes. MetS consists of visceral obesity, elevated blood pressure, impaired glucose metabolism, atherogenic dyslipidaemia (elevated triglycerides and low levels of high-density lipoprotein cholesterol), as well as other metabolic abnormalities. The underlying pathophysiology seems to be largely, but not uniquely, attributable to insulin resistance. Existing antihypertensive drugs were designed to lower blood pressure rather than to modify the metabolic abnormalities associated with hypertension. This review considers the role of renin-angiotensin system inhibition and especially the use of angiotensin receptor blockers (ARBs) in the treatment of hypertension in MetS. There are differences among ARBs. Among them is the uricosuric effect of losartan. Furthermore, telmisartan may function as a partial agonist of the peroxisome proliferator-activated receptor-gamma (PPAR-gamma). 相似文献
24.
Efstathios D. Pagourelias Ph.D. Georgios K. Efthimiadis Ph.D. Evangelia Kouidi Ph.D. Paraskevi Zorou M.Sc. Georgios Giannoglou Ph.D. Asterios Deligiannis Ph.D. Vasilis G Athyros Ph.D. Asterios Karagiannis Ph.D. Paraschos Geleris Ph.D. 《Echocardiography (Mount Kisco, N.Y.)》2013,30(2):131-139
Left ventricular hypertrophy (LVH) with intraventricular septum thickness (IVST) between 1.2 and 1.5 cm in athletes represents a “gray zone” between physiologic adaptation and mild hypertrophic cardiomyopathy (HCM). Various echo and laboratory parameters have been reported till now in the literature to discriminate the “gray zone” entities. Aim of this study was to assess the efficacy of these “classic” parameters in differentiating physiologic LVH in athletes from mild HCM in a highly selected population. Nine highly trained athletes with IVST (1.28 ± 0.07 cm), 9 patients with mild HCM (1.38 ± 0.11 cm), and 26 athletes without LVH (1.06 ± 0.09 cm; P < 0.0005) underwent echocardiographic study, cardiopulmonary treadmill exercise stress test, and brain natriuretic peptide (BNP) measurement before and after exercise. Among all parameters tested, 7 were found to significantly differ between “gray zone” groups. After bootstrapping analysis, it was found that athletes with left ventricular end‐diastolic diameter <4.74 cm, mitral deceleration time >200 ms, isovolumic relaxation time >94 ms, tricuspid E/A < 1.63, septum Em < 9.5 cm/sec, relative wall thickness >0.445, and a BNP value at rest >9.84 pg/mL had a greater possibility for having underlying cardiomyopathy. A 10‐point score based on these parameters showed accuracy (area under the curve = 0.958 [95%CI: 0.738–1.0; P = 0.00005, standard error = 0.0342]) for revealing HCM in a gray zone athletic population. Differentiation of adaptive LVH versus HCM in a gray zone population could be facilitated by recognition of certain features referring to LV dimensions, diastolic function, and BNP. 相似文献
25.
VG Sigmaringen 《MedR Medizinrecht》2003,21(2):119-121
Ohne Zusammenfassung 相似文献
26.
Long-term follow-up of patients with acute hypertriglyceridemia-induced pancreatitis 总被引:24,自引:0,他引:24
Athyros VG Giouleme OI Nikolaidis NL Vasiliadis TV Bouloukos VI Kontopoulos AG Eugenidis NP 《Journal of clinical gastroenterology》2002,34(4):472-475
BACKGROUND: An acute and potentially life-threatening complication of hypertriglyceridemia (HTG) is acute pancreatitis (AP). Hypertriglyceridemia, usually severe, may be primary in origin or secondary to alcohol abuse, diabetes mellitus, pregnancy, and use of drugs. STUDY: The efficacy of treatment to prevent relapses in 17 patients with AP attributed to HTG was investigated in the current prospective study. The mean follow-up period of patients was 42 months. Hypertriglyceridemia-induced AP comprised 6.9% of all patients with AP (n = 246) hospitalized in our clinic during the study (6 years). RESULTS: Causative conditions of HTG-induced AP were familial HTG in eight patients, HTG caused by uncontrolled diabetes mellitus in five, HTG aggravated by drugs in two (one by tamoxifen and one by fluvastatin), familial hyperchylomicronemia (HCM) in one, and lipemia of pregnancy in one. During the acute phase of pancreatitis, patients underwent standard treatment. Thereafter, HTG was efficiently controlled with high dosages of fibrates or a fibrate plus acipimox, except for the patient with HCM, who was on a specific diet (the only source of fat was a special oil consisting of medium chain triglyceride) and taking a high dosage of acipimox. One of the patients died during the acute phase of pancreatitis with acute respiratory distress syndrome. During follow-up, maintenance treatment was successful and only one patient relapsed, because he discontinued diet and drug treatment. CONCLUSION: Appropriate diet and drug treatment, including dose titration, of severe HTG is very effective in preventing relapses of HTG-induced AP. 相似文献
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29.
VG Berlin 《MedR Medizinrecht》2007,25(1):56-59
Abstrakt 1. Die Vereinbarung einer am Umsatz oder Gewinn einer Apotheke ausgerichteten Miete ist nach § 8 S. 2 ApoG unzul?ssig. Das
Verbot der Umsatzmiete gilt insbesondere für die Anmietung von Apothekenbetriebsr?umen.
2. Aus dem Gesamtgefüge der Vereinbarungen kann sich ergeben, dass die Vertragsparteien die Miete am Umsatz oder Gewinn ausgerichtet
haben und der Vermieter dadurch an den Ertr?gnissen der Apotheke teilhat.
3. Ein immens hoher Mietzins engt die wirtschaftliche Bewegungsfreiheit des Apothekers erheblich ein und macht ihn zumindest
indirekt vom Vermieter abh?ngig.
4. Der Umstand, dass die Apothekenansiedlung im Kontext eines Medizinischen Versorgungszentrums geplant ist, ?ndert nichts
an der uneingeschr?nkten Geltung des § 8 S. 2 ApoG. (Leits?tze des Bearbeiters) 相似文献
30.