全文获取类型
收费全文 | 14283篇 |
免费 | 1234篇 |
国内免费 | 19篇 |
专业分类
耳鼻咽喉 | 338篇 |
儿科学 | 551篇 |
妇产科学 | 283篇 |
基础医学 | 2052篇 |
口腔科学 | 187篇 |
临床医学 | 1907篇 |
内科学 | 3057篇 |
皮肤病学 | 246篇 |
神经病学 | 1516篇 |
特种医学 | 502篇 |
外国民族医学 | 1篇 |
外科学 | 1656篇 |
综合类 | 238篇 |
现状与发展 | 1篇 |
一般理论 | 12篇 |
预防医学 | 973篇 |
眼科学 | 282篇 |
药学 | 812篇 |
中国医学 | 38篇 |
肿瘤学 | 884篇 |
出版年
2021年 | 196篇 |
2020年 | 137篇 |
2019年 | 196篇 |
2018年 | 213篇 |
2017年 | 164篇 |
2016年 | 225篇 |
2015年 | 233篇 |
2014年 | 340篇 |
2013年 | 542篇 |
2012年 | 679篇 |
2011年 | 775篇 |
2010年 | 473篇 |
2009年 | 390篇 |
2008年 | 693篇 |
2007年 | 713篇 |
2006年 | 703篇 |
2005年 | 807篇 |
2004年 | 664篇 |
2003年 | 637篇 |
2002年 | 587篇 |
2001年 | 339篇 |
2000年 | 331篇 |
1999年 | 300篇 |
1998年 | 222篇 |
1997年 | 179篇 |
1996年 | 162篇 |
1995年 | 138篇 |
1994年 | 139篇 |
1993年 | 125篇 |
1992年 | 190篇 |
1991年 | 199篇 |
1990年 | 204篇 |
1989年 | 177篇 |
1988年 | 165篇 |
1987年 | 165篇 |
1986年 | 158篇 |
1985年 | 128篇 |
1984年 | 125篇 |
1983年 | 137篇 |
1982年 | 139篇 |
1981年 | 154篇 |
1980年 | 138篇 |
1979年 | 144篇 |
1978年 | 115篇 |
1977年 | 127篇 |
1976年 | 113篇 |
1975年 | 85篇 |
1974年 | 135篇 |
1973年 | 97篇 |
1972年 | 83篇 |
排序方式: 共有10000条查询结果,搜索用时 203 毫秒
151.
Th. Schmeiser W. Heit R. Arnold D. Bunjes M. Wiesneth B. Hertenstein W. Hampl H. Heimpel 《Journal of molecular medicine (Berlin, Germany)》1987,65(20):967-974
Summary Conditioning therapy with aggressive chemotherapy and irradiation induces a state of transient combined immunodeficiency in bonemarrow transplant recipients. This promotes the occurrence of severe cytomegalovirus (CMV) infections, the most frequent lethal complication after bone-marrow transplantation (BMT) at present.Forty-four BMT recipients received CMV-IgG-hyperimmunoglobulin for CMV prophylaxis intravenously. The efficacy of this prophylaxis and possible risk factors for the occurrence of CMV-induced interstitial pneumonia (IP) were analyzed. Risk factors for the promotion of a CMV-IP were: additional immunosuppressive therapy after BMT, CMV-positive serostatus of the recipient, CMV-seropositive granulocyte transfusion, CMV infection immediately prior to BMT, and HLA-haploidentical BMT. In this study the incidence of graftversus-host disease was low and was not associated with the incidence of CMV infections. The use of T-cell-depleted grafts did not result in increased CMV infections or IP and may possibly have improved the immunological reconstitution.Abbreviations BMT
Bone-marrow transplantation
- CMV
Cytomegalovirus
- CMV-IG
CMV-IgG-hyperimmunoglobulin
- GvHD
Graft-versus-host disease
- IP
Interstitial pneumonia
- IS
Immunosuppressive therapy 相似文献
152.
Effects of Escherichia coli and Porphyromonas gingivalis lipopolysaccharide on pregnancy outcome in the golden hamster. 总被引:5,自引:0,他引:5 下载免费PDF全文
This report describes the effects of two gram-negative bacterial endotoxin (lipopolysaccharide [LPS]) preparations on hamster pregnancy outcome variables. Single intravenous challenges with Escherichia coli and Porphyromonas gingivalis LPS on day 8 of pregnancy produced dose-dependent effects on fetal weight malformation and fetal resorption with E. coli LPS having potent embryolethal effects. Premating maternal exposure to P. gingivalis produced embryolethal effects similar to those of E. coli. These data suggest that maternal exposure to P. gingivalis LPS prior to and during pregnancy can induce deleterious effects on the developing fetus. 相似文献
153.
Molecular mechanism for loss of visual cortical responsiveness following brief monocular deprivation
A dramatic form of experience-dependent synaptic plasticity is revealed in visual cortex when one eye is temporarily deprived of vision during early postnatal life. Monocular deprivation (MD) alters synaptic transmission such that cortical neurons cease to respond to stimulation of the deprived eye, but how this occurs is poorly understood. Here we show in rat visual cortex that brief MD sets in motion the same molecular and functional changes as the experimental model of homosynaptic long-term depression (LTD), and that prior synaptic depression by MD occludes subsequent induction of LTD. The mechanisms of LTD, about which there is now a detailed understanding, therefore contribute to visual cortical plasticity. 相似文献
154.
Angiogenic factors prepared from rat Walker 256 mammary carcinoma, (TAF) and activated mouse peritoneal macrophages (MAF), were tested for their ability to stimulate vascularization during healing. They were applied to one of a pair of bilaterally symmetrical, autologous, isotopic, full thickness skin grafts in mice. Blood flow to treated and untreated graft pairs was compared by their uptake of injected 86Rb Cl, at 3 and 7 days after grafting. No difference was detected after treatment with either agent. We conclude that while angiogenic factors are important in vascularization during healing, this normally occurs at a near maximal rate and cannot be further enhanced. 相似文献
155.
Daniel Hork Franti eksvec Jaroslav Klal Arnold A. Adamyan Yurii D. Volynskii Olga S. Voronkova Leonid S. Kokov Klara Z. Gumargalieva 《Biomaterials》1986,7(6):467-470
In this study we report the results of clinical experiments, obtained with spherical particles made from poly(2-hydroxyethyl methacrylate) used in the embolization of arteriovenous anastomoses, in the suppression of pulmonary haemorrhage and haemoptysis and in the occlusion of some other arteries. So far we have used these particles in the treatment of 187 patients. It must be stressed that the advantage of spherical particles consists in the simplicity of their introduction into the blood vessel through a catheter, while in the blood vessel itself the particle swells in blood still more, when compared with the particle size in saline. This results in an immediate and permanent haemostatic effect. No revascularization occurs. 相似文献
156.
Baujat G Rio M Rossignol S Sanlaville D Lyonnet S Le Merrer M Munnich A Gicquel C Colleaux L Cormier-Daire V 《American journal of medical genetics. Part C, Seminars in medical genetics》2005,(1):4-11
Here, we report the clinical and molecular analysis of 75 patients with overgrowth and mental retardation, including 45 previously reported cases [Rio et al., 2003; Baujat et al., 2004]. Two groups are distinguished: group I corresponding to patients with recognizable overgrowth syndromes (Sotos syndrome (SS), Weaver syndrome (WS), Beckwith-Wiedemann syndrome, Simpson-Golabi-Behmel syndrome (SGBS), and del(22)(qter) syndrome) (60 cases) and group II corresponding to unclassified cases (15 patients). We investigated NSD1 and GPC3 deletions or mutations, 11p15 abnormalities, and 22qter deletions. Surprisingly, in Group I, two SS patients had 11p15 abnormalities and two patients with Beckwith-Wiedemann syndrome had NSD1 aberrations. In group II, two cases of del(22)(qter) were identified but neither NSD1, 11p15, nor GPC3 abnormalities were detected. These results emphasize the clinical and molecular overlap in overgrowth conditions. 相似文献
157.
OBJECTIVE: To investigate the retraction time, forces, and torques applied to the football helmet during removal of the face mask with different face-mask removal tools. DESIGN AND SETTING: Subjects retracted the face mask of a football helmet mounted to a force platform in a laboratory setting. They removed a standard face mask by cutting or removing (or both) the lateral plastic loop straps using 4 different tools: the Trainer's Angel (TA), FM Extractor (FM), power screwdriver (SD), and Quick Release System (QR) in a counterbalanced fashion. SUBJECTS: Eighteen certified athletic trainers participated in this study. MEASUREMENTS: We started measuring time when the subject picked up the tool and ended when the face mask was in a fully retracted position. Maximum forces and torques were measured from the force platform during the retraction process. RESULTS: The SD and QR retracted the face mask significantly faster than the TA and FM. Forces producing superior-inferior translation were least with the SD. The SD and QR produced less lateral translation and rotation and lateral flexion moment than the TA and FM. The FM produced less torque in the lateral flexion moment than the TA. CONCLUSIONS: Tools that removed the loop straps (SD, QR) were faster and produced less force and torque on the helmet than the tools that cut through the loop straps (TA, FM). 相似文献
158.
Peripheral Tolerance as a Multi-Step Mechanism 总被引:10,自引:0,他引:10
Günter J. Hämmerling Günther Schönrich Iris Ferber Bernd Arnold 《Immunological reviews》1993,133(1):93-104
159.
160.