Lumbar intraspinal mucous cyst: case report

We report a case of an intraspinal mucous cyst, or ganglionic cyst, that irritated the fifth nerve root on the left in a patient who had previously undergone L4-L5 discectomy due to lumbosciatica. After a few months of complete well-being, the patient complained of the return of sciantica in the L5 region. Clinically, it looked like the recurrence of disc hernia, however, tests showed the presence of an extradural ganglionic cyst adjacent to the left joint facet between lumbar vertebrae IV and V. This lesion was not seen using radiography or computed tomography prior to discectomy. Surgical excision of the lesion was followed by rapid and full remission of the clinical symptoms. Histological tests confirmed the diagnosis of ganglion cyst. Received: 23 August 2001/Accepted: 4 September 2001     

Activation of Coagulation and Fibrinolysis during Coronary Surgery: On-pump versus Off-pump Techniques

Background : The authors studied the changes in selected hemostatic variables in patients undergoing coronary surgery with on-pump coronary artery bypass grafting (CABG) or off-pump coronary artery bypass surgery (OPCAB) techniques.

Methods : Platelet counts and plasma concentrations of antithrombin, fibrinogen, D dimer, [alpha]2 antiplasmin, and plasminogen were measured preoperatively, 5 min after administration of heparin, 10 min after arrival in the intensive care unit, and 24 h after surgery in patients scheduled to undergo OPCAB (n = 15) or CABG (n = 15). To correct for dilution, hemostatic variables and platelet counts were adjusted for the changes in immunoglobulin G plasma concentrations and hematocrit, respectively.

Results : Adjusting for dilution, antithrombin and fibrinogen concentrations decreased to a similar extent in patients undergoing OPCAB or CABG (pooled means and 95% confidence limits of the mean: 95.5% of baseline, 93-98%, P = 0.002, and 91.7% of baseline, 88-95%, P = 0.0001), respectively, whereas [alpha]2-antiplasmin concentrations were unchanged. Only CABG was associated with a reduction in platelet counts (76% of baseline, 66-85%, P = 0.0001), plasminogen concentrations (96% of baseline, 91-99%, P = 0.011), and increased D-dimer formation (476%, 309-741%, P = 0.004). Twenty-four hours after surgery, platelet counts were still lower in patients undergoing CABG (P = 0.049), but all the investigated variables adjusted for dilution were similar in the two groups.     

Use of a new hemicellulose dressing (Veloderm) for the treatment of split-thickness skin graft donor sites A within-patient controlled study

A multi-centre, open, within-patient controlled study was performed on 23 adult burnt patients to investigate the effectiveness, safety and tolerability of Veloderm^® in comparison with Algisite M™ and Jaloskin^® in split-thickness skin graft donor site care. The areas dressed with Veloderm^® completely healed within 10–13 days in a significant higher proportion than the other two dressings (47.6% for Veloderm^® versus 26.3% for Algisite M™ and 10% for Jaloskin^®, P < 0.03), showing during the whole study less incidence of exudates and of peri-lesional erythema. The aesthetic outcome of the treated lesions after healing was significantly better for Veloderm^® (P = 0.0016). Veloderm^® and Jaloskin^® required very few renewals of the medication during the first week of treatment, while Algisite M™ needed several multiple re-dressings. Veloderm^® was judged better than the other two treatments as far as the acceptability (P < 0.001), ease of use (P < 0.001) and efficacy (P < 0.00001). Both pain during application or at removal of dressings and local infections were negligible with all treatments. No scars were formed in any skin donor site. In conclusion Veloderm^® is a safe and effective dressing for the re-epithelialization of the skin graft donor sites: it showed higher activity than the other two compared dressings.     

Outcome analysis of retroperitoneal laparoscopic heminephrectomy in children

PURPOSE: Retroperitoneal laparoscopic heminephrectomy is a relatively new, well tolerated, minimally invasive alternative to open surgery for children with a nonfunctioning moiety in a duplex kidney. We collected data to assess outcomes in our experience with this procedure. MATERIALS AND METHODS: Data were retrospectively gathered on all patients operated on for retroperitoneal laparoscopic heminephrectomy at our institution between February 2001 and November 2004. Followup ultrasound was performed in all patients, and additional imaging was done only when clinically indicated. RESULTS: Retroperitoneal laparoscopic heminephrectomy was performed in 18 girls and 4 boys (18 upper and 5 lower pole moieties). Indications included ureterocele (12 patients), ectopic ureter (9) and vesicoureteral reflux (5). Mean age at surgery was 5 years (range 4 months to 18 years). Four patients required conversion to an open procedure due to inadequate exposure and were excluded from further review. Urine leaks developed postoperatively in 3 patients and were treated with Foley catheter drainage and/or stent placement. Two patients were noted to have large (more than 5 cm) asymptomatic retroperitoneal fluid collections on followup ultrasound. Functional loss of the remaining ipsilateral moiety was confirmed by DMSA scan in 2 children (ages 6 and 7 months). Doppler studies confirmed normal hilar blood flow in both cases. Clinical presentation for this subgroup included fever on postoperative day 3 in 1 patient and hypertension at 32 months postoperatively in 1. Mean followup was 33 months (range 3 to 56). CONCLUSIONS: Although retroperitoneal laparoscopic renal ablative surgery in children appears to be relatively safe and is associated with low morbidity, serious complications may occur with subtle or even late presentation.     

Follicular lymphoma international prognostic index

The prognosis of follicular lymphomas (FL) is heterogeneous and numerous treatments may be proposed. A validated prognostic index (PI) would help in evaluating and choosing these treatments. Characteristics at diagnosis were collected from 4167 patients with FL diagnosed between 1985 and 1992. Univariate and multivariate analyses were used to propose a PI. This index was then tested on 919 patients. Five adverse prognostic factors were selected: age (> 60 years vs 60 years), Ann Arbor stage (III-IV vs I-II), hemoglobin level (< 120 g/L vs 120 g/L), number of nodal areas (> 4 vs 4), and serum LDH level (above normal vs normal or below). Three risk groups were defined: low risk (0-1 adverse factor, 36% of patients), intermediate risk (2 factors, 37% of patients, hazard ratio [HR] of 2.3), and poor risk ( 3 adverse factors, 27% of patients, HR = 4.3). This Follicular Lymphoma International Prognostic Index (FLIPI) appeared more discriminant than the International Prognostic Index proposed for aggressive non-Hodgkin lymphomas. Results were very similar in the confirmation group. The FLIPI may be used for improving treatment choices, comparing clinical trials, and designing studies to evaluate new treatments.      

Comparative study of coaxial phacoemulsification and microincision cataract surgery. One-year follow-up

PURPOSE: To evaluate the amount of ultrasound (US) used, best corrected visual acuity (BCVA), and corneal endothelial cell loss in bimanual microincision cataract surgery (MICS) and coaxial phacoemulsification. SETTING: Department of Ophthalmology, Universidade Gama Filho, Rio de Janeiro, Brazil. METHODS: A prospective randomized study included 30 patients (60 eyes) with bilateral cataract. All patients had coaxial phacoemulsification in 1 eye and MICS in the fellow eye. The US time and the effective US time were measured intraoperatively. The BCVA and central endothelial cell loss were evaluated in both groups over a 1-year follow-up. The results between the 2 groups were compared. RESULTS: The total US time was lower in the coaxial phacoemulsification group than in the MICS group; the means were 0.50 minutes +/- 0.33 (SD) and 0.82 +/- 0.39 minutes, respectively. The mean US power was similar between groups (mean 10.1% +/- 3.76% and 10.0% +/- 4.0%, respectively). The BCVA was similar between the groups from 24 hours to 1 year. The mean central corneal endothelial cell loss at 3 months was 4.66% +/- 6.10% in the coaxial phacoemulsification group and 4.45% +/- 5.06% in the MICS group and at 1 year, 6.00% +/- 6.72% and 8.82% +/- 7.39%, respectively. The only significant difference in the postoperative results between the 2 groups was central endothelial cell loss at the 1-year follow-up. CONCLUSIONS: The US time was longer in the MICS group than in the in the coaxial phacoemulsification group, but the mean US power was similar between groups. The BCVA was also similar between groups; however, the MICS group had more central endothelial cell loss at the 1-year follow-up.