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排序方式: 共有438条查询结果,搜索用时 15 毫秒
61.
Arielle Spitze David Gersztenkorn Nagham Al-Zubidi Sushma Yalamanchili Orlando Diaz Andrew G. Lee 《Neuro-ophthalmology (Aeolus Press)》2014,38(1):29-35
Intracranial dural arteriovenous fistulas (dAVFs) can produce a variety of symptoms depending on fistula location, size, and venous drainage. Although cavernous sinus fistulas (CCFs) classically present with symptoms of orbital venous congestion due to retrograde venous drainage into the superior ophthalmic vein (i.e. an arterialised “red eye”) (Miller NR. Neurosurg Focus 2007;23:1--15), dAVFs not localised to the cavernous sinus rarely present with a “red eye” and instead produce increased intracranial pressure, which can mimic idiopathic intracranial hypertension (IIH). The authors present a unique case of an intracranial dAVF with clinical features suggestive of both CCF and IIH. Clinicians should be aware of this possibility to avoid delayed diagnosis of the intracranial dAVF. 相似文献
62.
Y Liu EQ Wu AG Bensimon CP Fan Y Bao A Ganguli M Yang M Cifaldi P Mulani 《Advances in therapy》2012,29(7):620-634
Introduction
Biologic therapies have demonstrated efficacy and safety in several chronic systemic disorders. The authors indirectly compared response rates and costs per responder associated with biologic treatments for moderate-to-severe Crohn??s disease (CD), psoriasis (Ps), and/or rheumatoid arthritis (RA).Methods
A systematic literature search was performed to identify phase 3 randomized controlled trials of biologics for CD (adalimumab, infliximab), Ps (adalimumab, etanercept, infliximab, ustekinumab 45 mg, ustekinumab 90 mg), or methotrexate-refractory RA (abatacept, adalimumab, certolizumab, etanercept, golimumab, infliximab, rituximab, tocilizumab). Food and Drug Administration-approved dosing schedules were evaluated. Published response rates were extracted, with response defined in CD, Ps, and RA as: ??70-point reduction in CD Activity Index at 12 months; ??75% improvement in Psoriasis Area and Severity Index at 3 months; and ??50% improvement in American College of Rheumatology component scores at 6 months. Within each indication, mixed-treatment comparison meta-analyses were conducted to derive pooled estimates and 95% CIs of response rate difference versus placebo for each biologic, adjusting for cross-trial variation in control-arm response rates. Cost per responder was estimated for each biologic as projected per patient drug costs (2011 US$) divided by response rate difference.Results
Altogether, 23 publications were selected. In CD, 12-month cost per responder was estimated at $116,291 (95% CI $71,637?C208,348) for adalimumab and $125,169 (95% CI $60,532?C267,101) for infliximab. Among biologics approved in Ps, 3-month cost per responder was lowest for adalimumab ($9,756; 95% CI $8,668?C11,131), infliximab ($12,828; 95% CI $11,772?C13,922), and ustekinumab 45 mg ($13,821; 95% CI $12,599?C15,167). In RA, biologics with the lowest 6-month cost per responder were adalimumab ($27,853; 95% CI $19,284?C40,270), etanercept ($29,140; 95% CI $14,170?C61,030), and tocilizumab ($31,363; 95% CI $14,713?C64,232).Conclusion
Meta-analyses of clinical trials found considerable variation in cost-effectiveness of biologic therapies for CD, Ps, and RA. These results may help determine biologic utilization in these chronic diseases. 相似文献63.
Arielle H. Sheftall Deena J. Chisolm Emily R. Alexy Laura J. Chavez Rita M. Mangione-Smith Renée M. Ferrari Paula H. Song 《Journal of pediatric health care》2019,33(3):255-262
Introduction
Children with disabilities have significant health care needs, and receipt of care coordinator services may reduce caregiver burdens. The present study assessed caregivers’ experience and satisfaction with care coordination.Method
Caregivers of Medicaid-enrolled children with disabilities (n?=?2,061) completed a survey (online or by telephone) collecting information on the caregivers’ experiences and satisfaction with care coordination using the Family Experiences with Coordination of Care questionnaire.Results
Eighty percent of caregivers with a care coordinator reported receiving help making specialist appointments, and 71% reported help obtaining community services. Caregivers who reported that the care coordinator helped with specialist appointments or was knowledgeable, supportive, and advocating for children had increased odds of satisfaction (odds ratio?=?3.46, 95% confidence interval?=?[1.01, 11.77] and odds ratio?=?1.07, 95% confidence interval?=?[1.03, 1.11], respectively).Discussion
Findings show opportunities for improving care coordination in Medicaid-enrolled children with disabilities and that some specific elements of care coordination may enhance caregiver satisfaction with care. 相似文献64.
N‐glycolylneuraminic acid knockout reduces erythrocyte sequestration and thromboxane elaboration in an ex vivo pig‐to‐human xenoperfusion model 下载免费PDF全文
Arielle Cimeno Wessam Hassanein Beth M. French Jessica M. Powell Lars Burdorf Olga Goloubeva Xiangfei Cheng Dawn M. Parsell Jagdeece Ramsoondar Kasinath Kuravi Todd Vaught Mehmet C. Uluer Emily Redding Natalie O'Neill Christopher Laird Alena Hershfeld Ivan Tatarov Kathryn Thomas David Ayares Agnes M. Azimzadeh Richard N. Pierson III Rolf N. Barth John C. LaMattina 《Xenotransplantation》2017,24(6)
65.
66.
Stanford AD Sharif Z Corcoran C Urban N Malaspina D Lisanby SH 《The international journal of neuropsychopharmacology / official scientific journal of the Collegium Internationale Neuropsychopharmacologicum (CINP)》2008,11(4):563-576
Transcranial magnetic stimulation (TMS) and repetitive TMS (rTMS) have been used increasingly over the past few years to study both the pathophysiology of schizophrenia as well as the utility of focal neuromodulation as a novel treatment for schizophrenia. rTMS treatment studies to date have explored its effect on both positive and negative symptoms by targeting cortical regions thought to underlie these symptom clusters. Studies on auditory hallucinations have been largely positive, while efficacy for negative symptoms is equivocal. A better understanding of the functional abnormalities that accompany symptoms may facilitate the development of rTMS as a treatment modality. Furthermore, schizophrenia patients appear to have abnormal cortical inhibition, consistent with GABA and dopamine abnormalities in schizophrenia. The effect of TMS on GABA and dopamine neurotransmission has not been clearly delineated. Given the variability in cortical response to rTMS in schizophrenia, methods to optimize dosage are essential. Consideration of these factors among others may broaden the scope of utility of TMS for schizophrenia as well as enhance its efficacy. 相似文献
67.
Whether cocaine locomotor conditioning represents a cocaine positive effect; i.e., a Pavlovian cocaine conditioned response; or, a cocaine negative effect; i.e., interference with habituation to the test environment, is a subject of some controversy. Three separate experiments were conducted to compare the behavior (locomotion and grooming) of separate groups of rats given 1, 9 or 14 cocaine (10 mg/kg) treatments paired/unpaired with placement into an open-field arena. The behavior of the cocaine groups on subsequent saline tests were compared with the habituation rates of saline treated rats. After one cocaine pairing with the test environment, the subsequent behavior of the cocaine paired group on saline tests was similar to a non-habituated control group. In the two experiments with repeated cocaine pairings to the test environment, the subsequent behavior of the cocaine treated groups did not parallel that of the non-habituated saline control groups. These results were not explicable in terms of cocaine anti-habituation effects. It is suggested that cocaine contextual cues paired with cocaine treatment can activate cocaine memory traces which with subsequent cocaine treatments are reinforced and strengthened. In this way repeated cocaine use can forge conditioned stimulus connections to the cocaine behavioral response that are highly resistant to extinction. 相似文献
68.
Arielle Baskin-Sommers Cortney Simmons May Conley Shou-An Chang Suzanne Estrada Meghan Collins William Pelham Emil Beckford Haley Mitchell-Adams Nia Berrian Susan F. Tapert Dylan G. Gee B. J. Casey 《Proceedings of the National Academy of Sciences of the United States of America》2021,118(41)
In 2020, individuals of all ages engaged in demonstrations condemning police brutality and supporting the Black Lives Matter (BLM) movement. Research that used parent reports and trends commented on in popular media suggested that adolescents under 18 had become increasingly involved in this movement. In the first large-scale quantitative survey of adolescents’ exposure to BLM demonstrations, 4,970 youth (meanage = 12.88 y) across the United States highlighted that they were highly engaged, particularly with media, and experienced positive emotions when exposed to the BLM movement. In addition to reporting strong engagement and positive emotions related to BLM demonstrations, Black adolescents in particular reported higher negative emotions when engaging with different types of media and more exposure to violence during in-person BLM demonstrations. Appreciating youth civic engagement, while also providing support for processing complex experiences and feelings, is important for the health and welfare of young people and society. 相似文献
69.
Marie P. Grange Arielle R. Rosenberg Peter Horal Claude Desgranges 《International journal of cancer. Journal international du cancer》1998,75(5):804-813
Several lines of evidence underscore the important role of the humoral response specific for HTLV-I envelope protein in the protection against viral infection. One approach to producing efficient immunogens is to synthesize peptides corresponding to the primary amino-acid sequence of neutralizing epitopes found in the external sub-unit gp46. In this study, we have selected synthetic peptides overlapping the major linear neutralizing determinants described earlier and used them as immunogens in rabbits and mice. All rabbit polyclonal antisera raised against peptides recognized epitopes in a denaturated context as well as MAbs raised against the HB peptide (aa287-311). By contrast, synthetic peptides O (aa89-110), HH (aa190-209), T (aa190-212) and HB (aa287-311) have generated antibodies efficiently binding their epitopes in a native context, suggesting that these domains are well exposed both at the heterodimer and at the oligomer surface. None of the antibodies induced by synthetic peptides show in vitro neutralizing properties, even those with a good capacity to bind the native form of HTLV-I envelope proteins. Int. J. Cancer 75:804–813, 1998.© 1998 Wiley-Liss, Inc. 相似文献
70.
Sara Flanagan Arielle Gorstein Martha Nicholson Stephanie Bradish Diana Amanyire Andrew Gidudu Francis Aucur Julius Twesigye Faith Kyateka Samuel Balamaga Alison Buttenheim Emily Zimmerman 《Bulletin of the World Health Organization》2021,99(11):795
ObjectiveTo evaluate the impact of a peer-referral and clinic welcome programme for reducing barriers to adolescents’ uptake of family planning services in Uganda.MethodsWe developed an intervention using behavioural design and carried out a stratified, randomized controlled evaluation of the intervention in girls aged 15–19 years. Sexual and reproductive health clinics were randomized into control (56 clinics) and intervention groups (60 clinics). All intervention clinics received the core intervention (materials to create an adolescent-friendly environment and referral cards to give to friends), while a subset of clinics additionally received training in youth-friendly service provision. We collected clinics’ routine data on monthly numbers of visits by adults and adolescents over a 15-month baseline and 6-month intervention period, 2018–2020.FindingsIn multivariate regression analysis we found significant effects of the intervention on primary outcomes in the pooled intervention group compared with control. Mean monthly visits by adolescents increased by 45% (incidence rate ratio, IRR: 1.45; 95% confidence interval, CI: 1.14–1.85), or over five additional adolescent clients per clinic per month. The mean adolescent proportion of total clients improved by 5.3 percentage points (95% CI: 0.02–0.09). Within treatment arms, clinics receiving the training in youth-friendly service provision showed the strongest effects: a 62% increase (IRR: 1.62; 95% CI: 1.21–2.17) in adolescent clients, or over seven additional adolescents per clinic per month, relative to the control group.ConclusionA behavioural change intervention designed to target identified barriers can increase adolescents’ uptake of family planning counselling and services. 相似文献