全文获取类型
收费全文 | 3117篇 |
免费 | 227篇 |
国内免费 | 13篇 |
专业分类
耳鼻咽喉 | 14篇 |
儿科学 | 116篇 |
妇产科学 | 133篇 |
基础医学 | 560篇 |
口腔科学 | 6篇 |
临床医学 | 177篇 |
内科学 | 595篇 |
皮肤病学 | 97篇 |
神经病学 | 146篇 |
特种医学 | 97篇 |
外科学 | 329篇 |
综合类 | 142篇 |
一般理论 | 2篇 |
预防医学 | 260篇 |
眼科学 | 121篇 |
药学 | 336篇 |
中国医学 | 39篇 |
肿瘤学 | 187篇 |
出版年
2022年 | 42篇 |
2021年 | 58篇 |
2020年 | 27篇 |
2019年 | 47篇 |
2018年 | 56篇 |
2017年 | 31篇 |
2016年 | 51篇 |
2015年 | 69篇 |
2014年 | 94篇 |
2013年 | 133篇 |
2012年 | 238篇 |
2011年 | 262篇 |
2010年 | 122篇 |
2009年 | 98篇 |
2008年 | 173篇 |
2007年 | 157篇 |
2006年 | 173篇 |
2005年 | 164篇 |
2004年 | 143篇 |
2003年 | 138篇 |
2002年 | 111篇 |
2001年 | 97篇 |
2000年 | 95篇 |
1999年 | 73篇 |
1998年 | 48篇 |
1997年 | 26篇 |
1996年 | 20篇 |
1995年 | 23篇 |
1994年 | 28篇 |
1993年 | 23篇 |
1992年 | 56篇 |
1991年 | 47篇 |
1990年 | 37篇 |
1989年 | 38篇 |
1988年 | 29篇 |
1987年 | 30篇 |
1986年 | 35篇 |
1985年 | 30篇 |
1984年 | 22篇 |
1983年 | 17篇 |
1982年 | 11篇 |
1979年 | 12篇 |
1978年 | 15篇 |
1977年 | 13篇 |
1976年 | 11篇 |
1975年 | 11篇 |
1974年 | 11篇 |
1973年 | 15篇 |
1972年 | 11篇 |
1968年 | 12篇 |
排序方式: 共有3357条查询结果,搜索用时 15 毫秒
51.
52.
53.
54.
55.
56.
Arnab Bhattacharya Shyamanta Das Kamal Nath Dipak Dutta Sahoo Saddichha 《Annals of Indian Academy of Neurology》2012,15(2):161-162
Tuberous Sclerosis (TSC) is clinically marked by a triad of adenoma sebaceum, epilepsy and mental retardation. It can however manifest as various neuropsychiatric disorders. We report a patient who presented with TSC and co-morbid Obsessive Compulsive Disorder. 相似文献
57.
D. Bhattacharya H. Bhattacharya R. Thamizhmani D. S. Sayi R. Reesu M. Anwesh C. Kartick A. P. Bharadwaj M. Singhania A. P. Sugunan S. Roy 《European journal of clinical microbiology & infectious diseases》2014,33(2):157-170
This study aims to determine the clinical features and seasonal patterns associated with shigellosis, the antimicrobial resistance frequencies of the isolates obtained during the period 2006–2012 for 22 antibiotics, and the molecular characterization of multidrug-resistant strains isolated from endemic cases of shigellosis in the remote islands of India, with special reference to fluoroquinolone and third-generation cephalosporins resistance. During the period from January 2006 to December 2011, stool samples were obtained and processed to isolate Shigella spp. The isolates were evaluated with respect to their antibiotic resistance pattern and various multidrug resistance determinants, including resistance genes, quinolone resistance determinants, and extended-spectrum β-lactamase (ESBL) production. Morbidity for shigellosis was found to be 9.3 % among children in these islands. Cases of shigellosis occurred mainly during the rainy seasons and were found to be higher in the age group 2–5 years. A wide spectrum of resistance was observed among the Shigella strains, and more than 50 % of the isolates were multidrug-resistant. The development of multidrug-resistant strains was found to be associated with various drug-resistant genes, multiple mutations in the quinolone resistance-determining region (QRDR), and the presence of plasmid-mediated quinolone-resistant determinants and efflux pump mediators. This report represents the first presentation of the results of long-term surveillance and molecular characterization concerning antimicrobial resistances in clinical Shigella strains in these islands. Information gathered as part of the investigations will be instrumental in identifying emerging antimicrobial resistance, for developing treatment guidelines appropriate for that community, and to provide baseline data with which to compare outbreak strains in the future. 相似文献
58.
S. Bhattacharya 《Indian Journal of Plastic Surgery》2011,44(3):488-Dec;44(3):488
59.
S. Bhattacharya 《Indian Journal of Plastic Surgery》2011,44(3):497-Dec;44(3):497
60.
Members of the synaptobrevin/vesicle-associated membrane protein (VAMP) family in Drosophila are functionally interchangeable in vivo for neurotransmitter release and cell viability
下载免费PDF全文
![点击此处可从《Proceedings of the National Academy of Sciences of the United States of America》网站下载免费的PDF全文](/ch/ext_images/free.gif)
Bhattacharya S Stewart BA Niemeyer BA Burgess RW McCabe BD Lin P Boulianne G O'Kane CJ Schwarz TL 《Proceedings of the National Academy of Sciences of the United States of America》2002,99(21):13867-13872
Synaptobrevins or VAMPs are vesicle-associated membrane proteins, often called v-SNARES, that are important for vesicle transport and fusion at the plasma membrane. Drosophila has two characterized members of this gene family: synaptobrevin (syb) and neuronal synaptobrevin (n-syb). Mutant phenotypes and gene-expression patterns indicate that n-Syb is exclusively neuronal and required only for synaptic vesicle secretion, whereas Syb is ubiquitous and, as shown here, essential for cell viability. When the eye precursor cells were made homozygous for syb(-), the eye failed to develop. In contrast, n-syb(-) eye clones developed appropriately but failed to activate downstream neurons. To determine whether the two proteins are structurally specialized to accomplish these distinct in vivo functions, we have driven the expression of each gene in the absence of the other to look for phenotypic rescue. We find that expression of n-syb during eye development can rescue the cell lethality of the syb mutations, as can rat VAMP2 and cellubrevin. Expression of syb can restore synaptic transmission to n-syb mutants as assayed both by electroretinogram and recordings of excitatory junctional currents at the neuromuscular junction. Therefore, we find that Syb, which usually is not involved in synaptic function, can mediate Ca(2+)-triggered synaptic activity and that no particular specialization of the v-SNARE is required to differentiate synaptic exocytosis from other forms. 相似文献