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981.
982.
Clinical Rheumatology - Cardiac involvement in adult-onset Still’s disease (AOSD) usually manifests as a pericardial disease. Myocarditis is uncommon (prevalence of 7%). However, the... 相似文献
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Andreana Marino Simona Pergolizzi Eugenia R. Lauriano Giuseppe Santoro Francesca Spataro Francesco Cimino Antonio Speciale Antonia Nostro Giuseppe Bisignano 《APMIS : acta pathologica, microbiologica, et immunologica Scandinavica》2015,123(2):163-168
The Toll‐Like Receptor 2 (TLR2) plays an active and important role in Staphylococcus aureus‐induced chronic ocular inflammation. The aim of this study was to investigate the expression and function of TLR2 of corneal stromal cells in ex vivo rabbit model of S. aureus keratitis. Corneal buttons with sclera rims placed in an ex vivo air‐interface organ culture were assigned to two groups: corneas with epithelial and stromal abrasions. Each group was then divided into two sub‐groups exposed to UV‐killed S. aureus ATCC 6538P and S. aureus ATCC 29213, respectively. TLR2 and IL‐8 mRNA expressions were analyzed by quantitative real‐time RT‐PCR. TLR2 localization was visualized by immunofluorescence analysis. The results demonstrated that TLR2 and IL‐8 mRNA were significantly expressed in the stromal cells of the groups exposed to S. aureus strains. Moreover, it has been demonstrated that, after corneal injury, keratocytes differentiated into myofibroblasts became able to express TLR2 only when exposed to S. aureus. Identification of mechanisms regulation of corneal TLRs may lead to development of therapeutic interventions aimed at controlling corneal inflammation. This ex vivo model can be used to clarify the molecular events of bacterial‐corneal tissue interactions and their inflammatory consequences. 相似文献
985.
Kerk F. Kee Lisa Sparks Daniele C. Struppa Mirco A. Mannucci Alberto Damiano 《Health communication》2016,31(4):385-399
By integrating the simplicial model of social aggregation with existing research on opinion leadership and diffusion networks, this article introduces the constructs of simplicial diffusers (mathematically defined as nodes embedded in simplexes; a simplex is a socially bonded cluster) and simplicial diffusing sets (mathematically defined as minimal covers of a simplicial complex; a simplicial complex is a social aggregation in which socially bonded clusters are embedded) to propose a strategic approach for information diffusion of cancer screenings as a health intervention on Facebook for community cancer prevention and control. This approach is novel in its incorporation of interpersonally bonded clusters, culturally distinct subgroups, and different united social entities that coexist within a larger community into a computational simulation to select sets of simplicial diffusers with the highest degree of information diffusion for health intervention dissemination. The unique contributions of the article also include seven propositions and five algorithmic steps for computationally modeling the simplicial model with Facebook data. 相似文献
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Janine Braga de Souza Jacqueline de Souza Lara Maria Lopes de Castro Melissa Fabíola Siqueira Ranylson Marcello Leal Savedra 《Pharmaceutical development and technology》2019,24(3):283-292
This study aimed at evaluating the shake-flask use as a universal method to evaluate drug solubility in a biowaiver context as proposed by FDA, EMA and ANVISA. The solubility of losartan was determined in three buffers using the shake-flask method, intrinsic dissolution (ID) and Quantum Chemistry. Moreover, the evaluation of a losartan dissolution profile from coated tablets was conducted. The losartan low solubility in pH 1.2 and high solubility in pH 6.8 were observed using the shake-flask method. However, the solubility results using ID demonstrated its high solubility in pH 1.2 and 6.8. It was not possible to find conclusive results regarding the solubility of the drug in pH 4.5. The studies conducted by Quantum Chemistry provide molecular and electronic data that helped understand the losartan solvation in different pH values. Our experimental results defined that losartan can be classified as a low-solubility drug. In addition, this work shows that shake-flask cannot be a universal method of solubility studies in biowaiver context. Individual analysis will be necessary. The intrinsic dissolution should be considered as a complementary method. 相似文献
989.
Evaluating Communication Skills of Geriatrics Fellows: Interrater Agreement of an Objective Structured Clinical Examination
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Marcos Daniel Saraiva MD Maria Luiza de Melo Paulo MD Thiago Junqueira Avelino‐Silva MD Luiz Antonio Gil‐Junior MD Elina Lika Kikuchi MD Luciana Louzada Farias MD Rafael Lyra Rodrigues Alves MD Gisele Sayuri Suzuki MD Fábio Cesar Olivieri MD Valmari Cristina Aranha MSc Leonardo da Costa Lopes MD PhD Maria Cristina Guerra Passarelli MD PhD Julio Cesar Moriguti MD PhD Eduardo Ferrioli MD PhD Chao Lung Wen MD PhD Daniel Apolinário MD PhD Wilson Jacob‐Filho MD PhD 《Journal of the American Geriatrics Society》2016,64(1):206-207
990.
José Carlos Castillo Álvaro Castro-González Antonio Fernández-Caballero José Miguel Latorre José Manuel Pastor Alicia Fernández-Sotos Miguel A. Salichs 《Cognitive computation》2016,8(2):357-367
This paper introduces the architecture of an emotion-aware ambient intelligent and gerontechnological project named “Improvement of the Elderly Quality of Life and Care through Smart Emotion Regulation”. The objective of the proposal is to find solutions for improving the quality of life and care of the elderly who can or want to continue living at home by using emotion regulation techniques. A series of sensors is used for monitoring the elderlies’ facial and gestural expression, activity and behaviour, as well as relevant physiological data. This way the older people’s emotions are inferred and recognized. Music, colour and light are the stimulating means to regulate their emotions towards a positive and pleasant mood. Then, the paper proposes a gerontechnological software architecture that enables real-time, continuous monitoring of the elderly and provides the best-tailored reactions of the ambience in order to regulate the older person’s emotions towards a positive mood. After describing the benefits of the approach for emotion recognition and regulation in the elderly, the eight levels that compose the architecture are described. 相似文献