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21.
Todd B. Kashdan Leah M. Adams Antonina S. Farmer Patty Ferssizidis Patrick E. McKnight John B. Nezlek 《Archives of sexual behavior》2014,43(7):1417-1429
A growing literature attests to deficits in social and romantic life quality in people with elevated social anxiety, but no research to date has explored how intense intimate encounters influence social anxiety symptoms. This study investigated whether the presence and quality of sexual activity on a given day predicted less social anxiety and negative cognitions on a subsequent day. We also explored whether the benefits of sexual activity would be stronger for more socially anxious individuals. Over 21 days, 172 undergraduate students described the presence and quality of sexual activity, social anxiety symptoms, and use of social comparisons on the day in question. Time-lagged analyses determined that being sexually active on one day was related to less social anxiety symptoms and the generation of fewer negative social comparisons the next day. Furthermore, more intense experiences of pleasure and connectedness during sex predicted greater reductions in social anxiety the next day for people high in trait social anxiety, compared to those low in trait social anxiety. These results were similar regardless of whether sex occurred in the context of romantic relationships or on weekdays versus weekends. The results suggest that sexual activity, particularly when pleasurable and intimate, may mitigate some of the social anxiety and negative comparisons frequently experienced by people with high trait social anxiety. 相似文献
22.
Romina Vuono PhD Antonina Kouli MSc Emilie M. Legault BSc Lauriane Chagnon DEC Kieren S. Allinson FRCPath Alberto La Spada BSc REGISTRY Investigators of the European Huntington's Disease Network Ida Biunno PhD Roger A. Barker MRCP PhD Janelle Drouin-Ouellet PhD 《Movement disorders》2020,35(3):401-408
23.
Giammanco M 《Minerva endocrinologica》2000,25(3-4):75-79
In the present review the Author examines the natural history, clinical aspects, diagnostic aspects and surgical treatment representing the therapy for medullary thyroid carcinoma (MTC), with particular stress on the recommendation that a meticulous total thyroidectomy is always indicated, without leaving any residual thyroid gland tissue. Lymphadenectomy of the central part of neck is also recommended, with the abstraction of the jugular chain lymph nodes. In the case of positivity of one of those lymph nodes, it is necessary to perform a functional cervico-mediastinic lymphadenectomy. 相似文献
24.
Santagati A Granata G Santagati M Cutuli V Mangano NG Caruso A 《Arzneimittel-Forschung》2002,52(6):448-454
The synthesis, the analgesic and anti-inflammatory activities of two series of phenyl derivatives containing 5,6-dimethyl-thieno[2,3-d]pyrimidin-4(1H)-one and 4H-pyrimido[5,4-b]indol-4-one system, respectively, are reported. Two of these derivatives, 6A and 9B, showed interesting activities. The results of the pharmacological assays are discussed. 相似文献
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27.
Frolov VA Lizunov VA Dunina-Barkovskaya AY Samsonov AV Zimmerberg J 《Proceedings of the National Academy of Sciences of the United States of America》2003,100(15):8698-8703
Shape dynamics and permeability of a membrane neck connecting a vesicle and plasma membrane are considered. The neck is modeled by a lipid membrane tubule extended between two parallel axisymmetric rings. Within a range of lengths, defined by system geometry and mechanical properties of the membrane, the tubule has two stable shapes: catenoidal microtubule and cylindrical nanotubule. The permeabilities of these two shapes, measured as ionic conductivity of the tubule interior, differ by up to four orders of magnitude. Near the critical length the transitions between the shapes occur within less than a millisecond. Theoretical estimates show that the shape switching is controlled by a single parameter, the tubule length. Thus the tubule connection can operate as a conductivity microswitch, toggling the release of vesicle content in such cellular processes as "kiss-and-run" exocytosis. In support of this notion, bistable behavior of membrane connections between vesicles and the cell plasma membrane in macrophages is demonstrated. 相似文献
28.
Esposito S Faldella G Giammanco A Bosis S Friscia O Clerici M Principi N 《Vaccine》2002,20(23-24):2928-2932
Immunoglobulin G (IgG) antibody titres against pertussis antigens, Bordetella pertussis-specific proliferation and cytokine production by peripheral blood mononuclear cells (PBMCs) were evaluated at the age of 5-6 years in 13 children who had been pre-term infants with a gestational age (GA) of < or = 31 weeks, 10 who had been pre-term infants with a GA of 32-37 weeks, and 15 who had been term infants with a GA of 38-42 weeks. All of the infants had been immunised with a combined diphtheria, tetanus, tricomponent acellular pertussis and hepatitis B vaccine (DTaP-HBV) at 3, 5, and 11 months of post-natal age. Our results show that the long-term immune responses induced by primary pertussis vaccination in the pre-term infants (especially those with a GA of < or = 31 weeks) were qualitatively and quantitatively lower than those observed in the term infants. In order to maintain an adequate pertussis-specific immune response, in term children a booster at 5-6 years of age may be suggested, whereas in pre-term an earlier booster should be useful. 相似文献
29.
Giovanni M Giammanco Sarina Pignato Carmelita Santangelo Patrick A D Grimont Francine Grimont Giuseppe Giammanco 《Infection control and hospital epidemiology》2004,25(10):885-887
Agrobacterium isolates from intravenous catheters of three hospitalized patients were initially identified as A. tumefaciens, but inability to produce 3-ketolactose revealed that two of them were A. vitis. However, rDNA analysis correlated all of the isolates to A. tumefaciens. Pulsed-field gel electrophoresis analysis ascertained the nosocomial transmission of the infection. 相似文献
30.
Pignatello R Montenegro L Stancampiano AH Puleo A Puglisi G 《Current drug delivery》2005,2(2):185-189
Novel amide conjugates of the NSAID naproxen (NAP, 1) with short-chain alpha-alkylamino acids (C4 to C6 alkyl chain) were synthesized through a carbodiimide (EDAC)-assisted coupling reaction and evaluated as dermal prodrugs of NAP. The 2-alpha-aminobutyl derivative (2) showed lipophilicity similar to that of NAP, while the higher homologues (3) and (4) were more lipophilic than the parent drug, as assessed by CLogP and HPLC methods. The chemical and enzymatic hydrolysis of these compounds was evaluated in aqueous buffer solution (pH 7.4) and 80% human plasma. All compounds showed a good chemical stability (t1/2 = 88-133 h) but underwent a rapid enzymatic hydrolysis to NAP (t1/2 around 3 h). The bioconversion of prodrugs into NAP was confirmed by an in vivo test, since i.p. administration of compounds 2-4 to mice gave a similar analgesic response than the parent drug. In vitro skin permeation experiments were performed using adult human SCE samples mounted in Franz-type diffusion cells. The butyl derivative 2 that showed an increased aqueous solubility compared to NAP gave a 5-fold improvement of skin permeation compared to NAP. In conclusion, the conjugate 2 could be regarded as a good candidate to improve NAP topical delivery and will be further studied as a prodrug for topical administration of this drug. 相似文献