全文获取类型
收费全文 | 2256篇 |
免费 | 148篇 |
国内免费 | 6篇 |
专业分类
耳鼻咽喉 | 40篇 |
儿科学 | 72篇 |
妇产科学 | 52篇 |
基础医学 | 429篇 |
口腔科学 | 16篇 |
临床医学 | 246篇 |
内科学 | 484篇 |
皮肤病学 | 54篇 |
神经病学 | 203篇 |
特种医学 | 86篇 |
外科学 | 234篇 |
综合类 | 8篇 |
一般理论 | 2篇 |
预防医学 | 158篇 |
眼科学 | 22篇 |
药学 | 129篇 |
中国医学 | 8篇 |
肿瘤学 | 167篇 |
出版年
2023年 | 10篇 |
2022年 | 28篇 |
2021年 | 30篇 |
2020年 | 27篇 |
2019年 | 50篇 |
2018年 | 65篇 |
2017年 | 33篇 |
2016年 | 42篇 |
2015年 | 37篇 |
2014年 | 67篇 |
2013年 | 82篇 |
2012年 | 149篇 |
2011年 | 186篇 |
2010年 | 92篇 |
2009年 | 98篇 |
2008年 | 177篇 |
2007年 | 148篇 |
2006年 | 145篇 |
2005年 | 150篇 |
2004年 | 132篇 |
2003年 | 126篇 |
2002年 | 149篇 |
2001年 | 46篇 |
2000年 | 49篇 |
1999年 | 45篇 |
1998年 | 29篇 |
1997年 | 19篇 |
1996年 | 15篇 |
1995年 | 15篇 |
1994年 | 12篇 |
1993年 | 14篇 |
1992年 | 15篇 |
1991年 | 24篇 |
1989年 | 12篇 |
1988年 | 9篇 |
1987年 | 6篇 |
1986年 | 6篇 |
1985年 | 7篇 |
1984年 | 3篇 |
1983年 | 4篇 |
1982年 | 5篇 |
1980年 | 3篇 |
1979年 | 9篇 |
1978年 | 4篇 |
1974年 | 7篇 |
1973年 | 3篇 |
1972年 | 3篇 |
1971年 | 3篇 |
1969年 | 4篇 |
1968年 | 5篇 |
排序方式: 共有2410条查询结果,搜索用时 15 毫秒
31.
Dovi Stéphanie Acouetey Denis Zmirou-Navier Patrice Avogbe Paul Tossa Thomas Rémen Annick Barbaud José-Antonio Cornejo-Garcia Miguel Blanca Abraham Bohadana Christophe Paris Jean-Louis Guéant Rosa-Maria Guéant-Rodriguez 《Annals of allergy, asthma & immunology》2013,110(6):423-428.e5
BackgroundThe influence of genetic predictors of inflammation and atopy on occupational asthma in apprentices is not known.ObjectivesTo assess the influence of genetic polymorphisms of IL4RA, IL13, TNFA, IL1A, and IL5 on the decline of lung function and bronchial hyperresponsiveness in a prospective follow-up study of baker/pastry maker and hairdresser apprentices.MethodsA total of 351 apprentices were included in the study. We performed skin testing, spirometry, fractional exhaled nitric oxide measurement, and methacholine hyperreactivity testing at the initial visit and during and at the end of the 18-month training period. Gene variants of IL4RA, IL13, TNFA, IL1A, and IL5 were determined in DNA from nasal lavage.ResultsIL13 R130Q/IL4RA S478P or IL13 R130Q//IL4RA Q551R were significant predictors of the decrease of forced expiratory volume and forced vital capacity (P ≤ .006). Genotype GG of TNFAG308A was associated with bronchial hyperresponsiveness in the whole population and in nonatopic individuals (90.63% vs 9.38%; odds ratio, 3.78; 95% confidence interval, 1.10-12.83). TNFA GA and IL5 CC and TNFA GA and IL1A CC were 2 epistatic predictors of exhaled nitrogen monoxide decrease during follow-up (P = .02 and P = .004, respectively). The association with TNFA GA and IL1A CC was the most significant in nonatopic bakers (P < .001).ConclusionWe evidenced a predicting influence of IL13/IL4RA and TNFA in the early exposure to allergens and irritants that precedes occupational asthma. The significance of the associations in the absence of atopy suggests an influence of the genetics predictors related to inflammatory pathways. 相似文献
32.
33.
34.
Michael Bauer Uwe Kölsch Renate Krüger Nadine Unterwalder Karin Hameister Fabian Marc Kaiser Aglaia Vignoli Rainer Rossi Maria Pilar Botella Magdalena Budisteanu Monica Rosello Carmen Orellana Maria Isabel Tejada Sorina Mihaela Papuc Oliver Patat Sophie Julia Renaud Touraine Thusari Gomes Kirsten Wenner Xiu Xu Alexandra Afenjar Annick Toutain Nicole Philip Aleksandra Jezela-Stanek Ludwig Gortner Francisco Martinez Bernard Echenne Volker Wahn Christian Meisel Dagmar Wieczorek Salima El-Chehadeh Hilde Van Esch Horst von Bernuth 《Journal of clinical immunology》2015,35(2):168-181
35.
36.
37.
38.
Gerbaud E Harcaut E Coste P Erickson M Lederlin M Labèque JN Perron JM Cochet H Dos Santos P Durrieu-Jaïs C Laurent F Montaudon M 《The international journal of cardiovascular imaging》2012,28(4):783-794
To evaluate the incremental diagnostic and prognostic value of cardiac magnetic resonance (CMR) in patients with chest pain, raised troponin and unobstructed coronary arteries, and to compare subsequent event rates between diagnostic groups. 130 patients (mean age: 54?±?17) presenting with troponin-positive acute chest pain and unobstructed coronary arteries were included. All patients were managed according to European Society of Cardiology guidelines, including echocardiography, and had CMR within 6.2?±?5.3?days of presentation. During follow-up, major adverse cardiovascular events (MACE) were recorded. CMR provided a diagnosis in 100 of 130 patients (76.9%), with the remaining 30 (23.1%) having a normal examination. CMR diagnosed 37 (28.5%) acute myocardial infarctions, 34 (26.1%) myocarditis, 28 (21.5%) apical ballooning syndromes and 1 (0.8%) hypertrophic cardiomyopathy. When a single diagnosis was suspected by the referring physician, CMR validated this diagnosis in 32 patients (76.2%). CMR provided a formal diagnosis in 61 patients (69.3%) in which the clinical diagnosis was uncertain between at least two possibilities. CMR corrected a wrong diagnosis in 10 patients (7.7%). CMR-suggested diagnosis led to a modification of therapy in 42 patients (32.3%). Median follow-up was 34?months (interquartile range 24–49) in 124 patients. Sixteen patients (12.9%) experienced MACE. MACE rate was not different between patients with a conclusive CMR and normal CMR. In patients with acute troponin-positive chest pain and unobstructed coronary arteries, early CMR has important diagnostic and therapeutic implications. However its association with occurrence of MACE during mid term follow-up was not obvious. 相似文献
39.
Annick Bosch Joanne Riebschleger Linda van Loon 《International Journal of Mental Health Promotion, The》2017,19(3):159-172
Children of parents with a mental illness (COPMI) have a higher risk of acquiring a mental illness themselves. Feelings of guilt and shame could increase COPMI risks of acquiring mental health disorder symptoms. These feelings of guilt and shame could also impact the quality of the parent-child relationship. Data were drawn from the qualitative part of a mixed method study featuring 18 face-to-face interviews with Dutch COPMI aged 12–21. Interviewees were asked about their experiences with guilt and shame related to their parent with mental illness and the extent they felt that these feelings affected their relationships with their parents. Qualitative thematic analysis (QTA) revealed that most COPMI youth described feelings of guilt and some of them reported feelings of shame. They reported making behavioral adjustments especially using caution in parental communication. In their perception, guilt and shame did not have long-term impacts on their relationships with parents. 相似文献
40.