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91.
92.
Hackethal A Luck C von Hobe AK Eskef K Oehmke F Konrad L 《Archives of gynecology and obstetrics》2011,284(5):1179-1188
Purpose
To determine whether a structured questionnaire can improve preoperative assessment of patients with endometriosis. 相似文献93.
94.
Jean Bousquet Detlef Schröder-Bernhardi Claus Bachert G. Walter Canonica Victoria Cardona Elisio M. Costa Wienczyslawa Czarlewski Philippe Devillier Joao A. Fonseca Ludger Klimek Piotr Kuna Olga Lourenco Joaquim Mullol Oliver Pfaar Nhân Pham-Thi Boleslaw Samolinski Julia Saueressig Glenis K. Scadding Ann-Kathrin Stroh Sophie Scheire Eric Van Ganse Torsten Zuberbier 《Clinical and experimental allergy》2021,51(8):1033-1045
95.
Ramiro Garzon Stefano Volinia Dimitrios Papaioannou Deedra Nicolet Jessica Kohlschmidt Pearlly S. Yan Krzysztof Mrózek Donna Bucci Andrew J. Carroll Maria R. Baer Meir Wetzler Thomas H. Carter Bayard L. Powell Jonathan E. Kolitz Joseph O. Moore Ann-Kathrin Eisfeld James S. Blachly William Blum Michael A. Caligiuri Richard M. Stone Guido Marcucci Carlo M. Croce John C. Byrd Clara D. Bloomfield 《Proceedings of the National Academy of Sciences of the United States of America》2014,111(52):18679-18684
96.
Katarina Shahwan Martina Hesse Ann-Kathrin Mork Georg Herrler Christine Winter 《Viruses》2013,5(8):1924-1933
The spike proteins of a number of coronaviruses are able to bind to sialic acids present on the cell surface. The importance of this sialic acid binding ability during infection is, however, quite different. We compared the spike protein of transmissible gastroenteritis virus (TGEV) and the spike protein of infectious bronchitis virus (IBV). Whereas sialic acid is the only receptor determinant known so far for IBV, TGEV requires interaction with its receptor aminopeptidase N to initiate infection of cells. Binding tests with soluble spike proteins carrying an IgG Fc-tag revealed pronounced differences between these two viral proteins. Binding of the IBV spike protein to host cells was in all experiments sialic acid dependent, whereas the soluble TGEV spike showed binding to APN but had no detectable sialic acid binding activity. Our results underline the different ways in which binding to sialoglycoconjugates is mediated by coronavirus spike proteins. 相似文献
97.
Schuster Simon Ozga Ann-Kathrin Stellmann Jan-Patrick Deb-Chatterji Milani Häußler Vivien Matschke Jakob Gerloff Christian Thomalla Götz Magnus Tim 《Journal of neurology》2019,266(6):1481-1489
Journal of Neurology - To analyze the treatment response in patients with primary angiitis of the central nervous system (PACNS). In a single-center retrospective observational study, we assessed... 相似文献
98.
Wiontzek M Matziolis G Schuchmann S Gaber T Krocker D Duda G Burmester GR Perka C Buttgereit F 《Clinical and experimental rheumatology》2006,24(4):366-372
OBJECTIVE: Glucocorticoids and selective COX-2 inhibitors are potent anti-inflammatory agents. They are also suggested to influence bone physiology and remodeling. Here we searched for effects of dexamethasone and celecoxib on crucial parameters of bone physiology that could be therapeutically relevant. METHODS: The human osteosarcoma cell line MG-63 was used to measure effects of these drugs on (i) intracellular calcium concentration ([Ca2+]i) using a microfluorometric technique, (ii) alkaline phosphatase and osteocalcin levels (EIA) and (iii) the expression of cox-2 mRNA (quantitative real time PCR). Measurements were performed in Vitamine D-incubated quiescent cells and in cells stimulated with TNF-alpha and IL-1beta. RESULTS: We found the cytokine-stimulation to increase [Ca2+]i which was prevented by dexamethasone already after 30 min and still after 48 h. Dexamethasone was without any effect on [Ca2+]i in quiescent cells. Celecoxib had no measurable short-term or long-term effects neither in quiescent nor in stimulated cells. Vitamin D stimulated the expression of cox-2 mRNA which was further enhanced by TNF-alpha/IL-1beta. Dexamethasone did not have any measurable effects on COX-2 expression after 30 min, but a pronounced inhibition was seen after 48 h. In contrast, celecoxib had no effect on COX-2 expression. Neither of the drugs had any effect on the secretion of alkaline phosphatase and osteocalcin. CONCLUSION: We found dexamethasone to inhibit the [Ca2+]i increase in MG-63 cells following stimulation and to reduce considerably COX-2 expression via the genomic pathway. In contrast, celecoxib did not show any measurable short-term or long-term effects on the parameters of bone physiology measured. 相似文献
99.
Wilfried Rossoll Ann-Kathrin Kr?ning Uta-Maria Ohndorf Clemens Steegborn Sibylle Jablonka Michael Sendtner 《Human molecular genetics》2002,11(1):93-105
Spinal muscular atrophy (SMA), the most common hereditary motor neuron disease in children and young adults is caused by mutations in the telomeric survival motor neuron (SMN1) gene. The human genome, in contrast to mouse, contains a second SMN gene (SMN2) which codes for a gene product which is alternatively spliced at the C-terminus, but also gives rise to low levels of full-length SMN protein. The reason why reduced levels of the ubiquitously expressed SMN protein lead to specific motor neuron degeneration without affecting other cell types is still not understood. Using yeast two-hybrid techniques, we identified hnRNP-R and the highly related gry-rbp/hnRNP-Q as novel SMN interaction partners. These proteins have previously been identified in the context of RNA processing, in particular mRNA editing, transport and splicing. hnRNP-R and gry-rbp/hnRNP-Q interact with wild-type Smn but not with truncated or mutant Smn forms identified in SMA. Both proteins are widely expressed and developmentally regulated with expression peaking at E19 in mouse spinal cord. hnRNP-R binds RNA through its RNA recognition motif domains. Interestingly, hnRNP-R is predominantly located in axons of motor neurons and co-localizes with Smn in this cellular compartment. Thus, this finding could provide a key to understand a motor neuron-specific Smn function in SMA. 相似文献
100.
Reiß Franziska Napp Ann-Kathrin Erhart Michael Devine Janine Dadaczynski Kevin Kaman Anne Ravens-Sieberer Ulrike 《Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz》2023,66(4):391-401
Bundesgesundheitsblatt - Gesundheitsforschung - Gesundheitsschutz - Die COVID-19-Pandemie hat das Lernen und die Gesundheit von Kindern und Jugendlichen beeinflusst. Ziel des Beitrags ist,... 相似文献