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排序方式: 共有785条查询结果,搜索用时 15 毫秒
781.
Katie M. Williams Michalis Georgiou Angelos Kalitzeos Isabelle Chow Pirro G. Hysi Anthony G. Robson Gareth Lingham Fred K. Chen David A. Mackey Andrew R. Webster Christopher J. Hammond Polina Prokhoda Joseph Carroll Michel Michaelides Omar A. Mahroo 《Investigative ophthalmology & visual science》2022,63(6)
PurposeWe investigated axial length (AL) distributions in inherited retinal diseases (IRDs), comparing them with reference cohorts.MethodsAL measurements from IRD natural history study participants were included and compared with reference cohorts (TwinsUK, Raine Study Gen2-20, and published studies). Comparing with the Raine Study cohort, formal odds ratios (ORs) for AL ≥ 26 mm or AL ≤ 22 mm were derived for each IRD (Firth''s logistic regression model, adjusted for age and sex).ResultsMeasurements were available for 435 patients (median age, 19.5 years). Of 19 diseases, 10 had >10 participants: ABCA4 retinopathy; CNGB3- and CNGA3-associated achromatopsia; RPGR-associated disease; RPE65-associated disease; blue cone monochromacy (BCM); Bornholm eye disease (BED); TYR- and OCA2-associated oculocutaneous albinism; and GPR143-associated ocular albinism. Compared with the TwinsUK cohort (n = 322; median age, 65.1 years) and Raine Study cohort (n = 1335; median age, 19.9 years), AL distributions were wider in the IRD groups. Increased odds for longer ALs were observed for BCM, BED, RPGR, RPE65, OCA2, and TYR; increased odds for short AL were observed for RPE65, TYR, and GPR143. In subanalysis of RPGR-associated disease, longer average ALs occurred in cone–rod dystrophy (n = 5) than rod–cone dystrophy (P = 0.002).ConclusionsSeveral diseases showed increased odds for longer AL (highest OR with BCM); some showed increased odds for shorter AL (highest OR with GPR143). Patients with RPE65- and TYR-associated disease showed increased odds for longer and for shorter eyes. Albinism genes were associated with different effects on AL. These findings add to the phenotype of IRDs and may yield insights into mechanisms of refractive error development. 相似文献
782.
Christos Dimitrios Kakos Angelos Papanikolaou Ioannis A Ziogas Georgios Tsoulfas 《World journal of gastrointestinal surgery》2023,15(5):776-787
Minimally invasive donor hepatectomy (MIDH) is a relatively novel procedure that can potentially increase donor safety and contribute to faster rehabilitation of donors. After an initial period in which donor safety was not effectively validated, MIDH currently seems to provide improved results, provided that it is conducted by experienced surgeons. Appropriate selection criteria are crucial to achieve better outcomes in terms of complications, blood loss, operative time, and hospital stay. Beyond a pure laparoscopic technique, various approaches have been recommended such as hand-assisted, laparoscopic-assisted, and robotic donation. The latter has shown equal outcomes compared to open and laparoscopic approaches. A steep learning curve seems to exist in MIDH, mainly due to the fragility of the liver parenchyma and the experience needed for adequate control of bleeding. This review investigated the challenges and the opportunities of MIDH and the barriers to its global dissemination. Surgeons need expertise in liver transplantation, hepatobiliary surgery, and minimally invasive techniques to perform MIDH. Barriers can be categorized into surgeon-related, institutional-related, and accessibility. More robust data and the creation of international registries are needed for further evaluation of the technique and the acceptance from more centers worldwide. 相似文献
783.
Angelos Daniilidis Sonia Charitidou Stamatios Petousis Chrysoula MargioulaSiarkou Anastasios Liberis Konstantinos Dinas 《Clinical Case Reports》2021,9(9)
Isolated tubal torsion is an unusual cause of acute abdominal pain in young sexually inactive patients. However, it should be still taken into account regarding the differential diagnosis of such conditions. 相似文献
784.
Antonio Rojas-García Sabrina Lingeman Angelos P. Kassianos 《British journal of health psychology》2023,28(4):952-971
Purpose
Recommendations for exclusive breastfeeding are not often adhered to despite the robust evidence of its benefits. This systematic review aims to collate evidence on the attitudes mothers and health care providers have towards breastfeeding interventions to understand what aspects best contribute to acceptability and feasibility.Methods
This review further investigates the value of identifiable behaviour change techniques (BCTs) to uncover which components of an intervention are perceived to be most useful and acceptable. The main biomedical databases were searched, and 17 (n = 17) studies met the inclusion criteria.Results
A total of nine BCTs were identified within the interventions. The thematic analysis produced four main domains: usefulness, accessibility, value and sustainability. Women discussed the importance of the support they received in these interventions and demonstrated a positive view towards three BCTs: ‘social support (unspecified)’, ‘instruction on how to perform behaviour’ and ‘demonstration of behaviour’. Additionally, women highlighted the benefit of personal, non-clinical and flexible emotional and practical support from peers, lactation consultants and support groups. Health care providers echoed these opinions and specifically highlighted the usefulness of interventions that allowed for continuity of care and more personal breastfeeding support.Conclusions
These findings suggest that ongoing practical as well as emotional support is crucial for standard in-hospital support to succeed at increasing breastfeeding rates. Future research would need to better understand the nuances of the interventions among women and providers to enhance their implementation. 相似文献785.
Heiner Wedemeyer Tammo L. Tergast Jeffrey V. Lazarus Homie Razavi Kostas Bakoyannis Ricardo Baptista-Leite Marco Bartoli Philip Bruggmann Cristian-Silviu Buşoi Maria Buti Manuel Carballo Laurent Castera Massimo Colombo Rodrigo Sousa Coutinho Yuval Dadon Gamal Esmat Rafael Esteban Joan Colom Farran Mark Gillyon-Powell David Goldberg Sharon Hutchinson Harry L. A. Janssen George Kalamitsis Loreta A. Kondili John S. Lambert Rui Tato Marinho Mojca Maticic Aldo Patricello Markus Peck-Radosavljevic Stanislas Pol Mario Poljak Cora Pop Tomislov Sokol Vana Sypsa Nurdan Tözün Zobair Younossi Alessio Aghemo George V. Papatheodoridis Angelos Hatzakis 《Liver international》2023,43(2):276-291
In 2016, the Hepatitis B and C Public Policy Association (HepBCPPA), gathered all the main stakeholders in the field of hepatitis C virus (HCV) to launch the now landmark HCV Elimination Manifesto, calling for the elimination of HCV in the EU by 2030. Since then, many European countries have made progress towards HCV elimination. Multiple programmes—from the municipality level to the EU level—were launched, resulting in an overall decrease in viremic HCV infections and liver-related mortality. However, as of 2021, most countries are not on track to reach the 2030 HCV elimination targets set by the WHO. Moreover, the COVID-19 pandemic has resulted in a decrease in HCV diagnoses and fewer direct-acting antiviral treatment initiations in 2020. Diagnostic and therapeutic tools to easily diagnose and treat chronic HCV infection are now well established. Treating all patients with chronic HCV infection is more cost-saving than treating and caring for patients with liver-related complications, decompensated cirrhosis or hepatocellular carcinoma. It is more important than ever to reinforce and scale-up action towards HCV elimination. Yet, efforts urgently need the dedicated commitment of policymakers at all governmental and policy levels. Therefore, the third EU Policy Summit, held in March 2021, featured EU parliamentarians and other key decision makers to promote dialogue and take strides towards securing wider EU commitment to advance and achieve HCV elimination by 2030. We have summarized the key action points and reported the ‘Call-to-Action’ statement supported by all the major relevant European associations in the field. 相似文献