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排序方式: 共有542条查询结果,搜索用时 15 毫秒
101.
Nap RE Andriessen MP Meessen NE Miranda Ddos R van der Werf TS 《Emerging infectious diseases》2008,14(10):1518-1525
In The Netherlands a major part of preparedness planning for an epidemic or pandemic consists of maintaining essential public services, e.g., by the police, fire departments, army personnel, and healthcare workers. We provide estimates for peak demand for healthcare workers, factoring in healthcare worker absenteeism and using estimates from published epidemiologic models on the expected evolution of pandemic influenza in relation to the impact on peak surge capacity of healthcare facilities and intensive care units (ICUs). Using various published scenarios, we estimate their effect in increasing the availability of healthcare workers for duty during a pandemic. We show that even during the peak of the pandemic, all patients requiring hospital and ICU admission can be served, including those who have non-influenza-related conditions. For this rigorous task differentiation, clear hierarchical management, unambiguous communication, and discipline are essential and we recommend informing and training non-ICU healthcare workers for duties in the ICU. 相似文献
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SJ Mundell A-L Matharu S Nisar TM Palmer JL Benovic E Kelly 《British journal of pharmacology》2010,159(3):518-533
Background and purpose:
We have investigated the effect of deletions of a postsynaptic density, disc large and zo-1 protein (PDZ) motif at the end of the COOH-terminus of the rat A2B adenosine receptor on intracellular trafficking following long-term exposure to the agonist 5′-(N-ethylcarboxamido)-adenosine.Experimental approach:
The trafficking of the wild type A2B adenosine receptor and deletion mutants expressed in Chinese hamster ovary cells was studied using an enzyme-linked immunosorbent assay in combination with immunofluorescence microscopy.Key results:
The wild type A2B adenosine receptor and deletion mutants were all extensively internalized following prolonged treatment with NECA. The intracellular compartment through which the Gln325-stop receptor mutant, which lacks the Type II PDZ motif found in the wild type receptor initially trafficked was not the same as the wild type receptor. Expression of dominant negative mutants of arrestin-2, dynamin or Eps-15 inhibited internalization of wild type and Leu330-stop receptors, whereas only dominant negative mutant dynamin inhibited agonist-induced internalization of Gln325-stop, Ser326-stop and Phe328-stop receptors. Following internalization, the wild type A2B adenosine receptor recycled rapidly to the cell surface, whereas the Gln325-stop receptor did not recycle.Conclusions and implications:
Deletion of the COOH-terminus of the A2B adenosine receptor beyond Leu330 switches internalization from an arrestin- and clathrin-dependent pathway to one that is dynamin dependent but arrestin and clathrin independent. The presence of a Type II PDZ motif appears to be essential for arrestin- and clathrin-dependent internalization, as well as recycling of the A2B adenosine receptor following prolonged agonist addition. 相似文献105.
A.J. van Geest R.J. van Dooren-Greebe M.P.M. Andriessen C.E.M. Blomjous I.H. Go 《Journal of the European Academy of Dermatology and Venereology》1999,12(1):47-50
BACKGROUND: To our best knowledge this is the second case ever described of familial primary cryofibrinogenemia (CFG). PATIENTS: A 29-year-old Moroccan female and two of her three children suffered from painful purpura, slow healing small ulcerations and edema of both feet during the winter season. Laboratory investigations revealed the presence of cryofibrinogen in their blood plasma. All three patients were otherwise healthy and no associated disease could be demonstrated. CONCLUSIONS: The diagnosis of CFG has to be considered in patients with livedo reticularis, edema, painful purpura and slow healing ulcera after cold exposure. Cryofibrinogen-precipitates in the blood plasma have to be determined. Because secondary CFG occurs much more frequently than the primary form, it is important to rule out associated diseases through extensive physical examination and laboratory investigations. This communication also stresses the importance of a through family history of patients with CFG. An autosomal dominant mode of inheritance is supposed. 相似文献
106.
R Wanitphakdeedecha TH Nguyen TM Chen 《Journal of the European Academy of Dermatology and Venereology》2010,24(4):445-448
Background Appropriate pricing for medical services of not‐for‐profit hospital is necessary. The prices should be fair to the public and should be high enough to cover the operative costs of the organization. Objective The purpose of this study was to determine the cost and unit cost of medical services performed at the Mohs and Dermasurgery Unit (MDU), Department of Dermatology, The University of Texas – MD Anderson Cancer Center, Houston, TX from the healthcare provider’s perspective. Methods MDU costs were retrieved from the Financial Department for fiscal year 2006. The patients’ statistics were acquired from medical records for the same period. Unit cost calculation was based on the official method of hospital accounting. Results The overall unit cost for each patient visit was $673.99 United States dollar (USD). The detailed unit cost of nurse visit, new patient visit, follow‐up visit, consultation, Mohs and non‐Mohs procedure were, respectively, $368.27, $580.09, $477.82, $585.52, $1,086.12 and $858.23 USD. With respect to a Mohs visit, the unit cost per lesion and unit cost per stage were $867.89 and $242.30 USD respectively. Conclusions Results from this retrospective study provide information that may be used for pricing strategy and resource allocation by the administrative board of MDU. 相似文献
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J. Zweegers J.M.M. Groenewoud J.M.P.A. van den Reek M.E. Otero P.C.M. van de Kerkhof R.J.B. Driessen P.P.M. van Lümig M.D. Njoo P.M. Ossenkoppele J.M. Mommers M.I.A. Koetsier W.P. Arnold M.P.M. Andriessen A.L.A. Kuijpers M.A.M. Berends W. Kievit E.M.G.J. de Jong 《The British journal of dermatology》2017,176(4):1001-1009
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David J. Goldberg MD JD Anneke Andriessen PhD Ashish C. Bhatia MD FAAD Michael H. Gold MD FAAD Amy B. Lewis MD Margarita S. Lolis MD FAAD Jason H. Miller MD FAAD Adriana Ros MD FAAD 《Journal of Cosmetic Dermatology》2023,22(11):3026-3032