全文获取类型
收费全文 | 63330篇 |
免费 | 4575篇 |
国内免费 | 334篇 |
专业分类
耳鼻咽喉 | 635篇 |
儿科学 | 1602篇 |
妇产科学 | 1539篇 |
基础医学 | 7844篇 |
口腔科学 | 1537篇 |
临床医学 | 6358篇 |
内科学 | 14385篇 |
皮肤病学 | 809篇 |
神经病学 | 5001篇 |
特种医学 | 1916篇 |
外国民族医学 | 2篇 |
外科学 | 9741篇 |
综合类 | 1010篇 |
现状与发展 | 1篇 |
一般理论 | 103篇 |
预防医学 | 5254篇 |
眼科学 | 1858篇 |
药学 | 4428篇 |
中国医学 | 140篇 |
肿瘤学 | 4076篇 |
出版年
2023年 | 292篇 |
2022年 | 463篇 |
2021年 | 1158篇 |
2020年 | 724篇 |
2019年 | 1010篇 |
2018年 | 1244篇 |
2017年 | 848篇 |
2016年 | 968篇 |
2015年 | 1136篇 |
2014年 | 1774篇 |
2013年 | 2809篇 |
2012年 | 3774篇 |
2011年 | 4115篇 |
2010年 | 2346篇 |
2009年 | 2192篇 |
2008年 | 4009篇 |
2007年 | 4193篇 |
2006年 | 4020篇 |
2005年 | 4115篇 |
2004年 | 3842篇 |
2003年 | 3455篇 |
2002年 | 3415篇 |
2001年 | 730篇 |
2000年 | 623篇 |
1999年 | 722篇 |
1998年 | 742篇 |
1997年 | 610篇 |
1996年 | 492篇 |
1995年 | 491篇 |
1994年 | 466篇 |
1993年 | 440篇 |
1992年 | 531篇 |
1991年 | 509篇 |
1990年 | 417篇 |
1989年 | 438篇 |
1988年 | 396篇 |
1987年 | 373篇 |
1986年 | 355篇 |
1985年 | 419篇 |
1984年 | 432篇 |
1983年 | 394篇 |
1982年 | 528篇 |
1981年 | 443篇 |
1980年 | 485篇 |
1979年 | 301篇 |
1978年 | 321篇 |
1977年 | 321篇 |
1976年 | 261篇 |
1975年 | 287篇 |
1974年 | 246篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
21.
Isabella Sch?ll George Boltz-Nitulescu Erika Jensen-Jarolim 《Journal of controlled release》2005,104(1):1-27
For the treatment of infectious diseases, cancer and allergy, the directed induction of an appropriate immune response is the ultimate goal. Therefore, with the development of pure, often very small proteins, peptides or DNA by molecular biology techniques, the research for suitable adjuvants or delivery systems became increasingly important. Particle formulations are made of a variety of materials, including lipids, proteins or amino acids, polysaccharides, polyacrylic substances or organic acids. Microparticles serve as vehicles and provide a depot for the entrapped or coupled antigen. The release occurs in a pulsatile or continuous manner, a feature, which is well controllable for many particulate systems. Particles attract antigen presenting cells to the administration site, thereby guaranteeing the efficient presentation of the antigen to the immune system. Importantly, particles also protect the entrapped substance. This is especially necessary after oral application to avoid gastric or tryptic breakdown. In this article, the design and construction of different antigen delivery systems and their immune effects, with special focus on the suitability for allergy treatment, are discussed. 相似文献
22.
Edward M Messing Judith Manola George Wilding Kathleen Propert Jonathan Fleischmann E David Crawford J Edson Pontes Richard Hahn Donald Trump 《Journal of clinical oncology》2003,21(7):1214-1222
PURPOSE: To evaluate the role of adjuvant interferon alfa after complete resection of locally extensive renal cell carcinoma. PATIENTS AND METHODS: A total of 283 eligible patients with pT3-4a and/or node-positive disease were randomly assigned after radical nephrectomy and lymphadenectomy to observation or to interferon alfa-NL (Wellferon, Burroughs-Wellcome, Research Park, NC) given daily for 5 days every 3 weeks for up to 12 cycles. Patients were stratified on the basis of pathologic stage. Patients remained on treatment until documented recurrence, excessive toxicity, or patient/physician preference deemed removal appropriate. RESULTS: At median follow-up of 10.4 years, median survival was 7.4 years in the observation arm and 5.1 year in the treatment arm (log-rank P =.09). Median recurrence-free survival was 3.0 years in the observation arm and 2.2 years in the interferon arm (P =.33). Performance status (P =.003), nodal status (N2 v N0, P <.0001), and tumor stage (P =.0002) were significant prognostic factors in multivariate analysis. A proportional hazards model examining the effects of treatment arm and time to recurrence on survival after recurrence among patients who recurred found that random assignment to interferon treatment (P =.009) and shorter time to recurrence (P <.0001) were independent predictors of shorter survival after recurrence. Although no lethal toxicities were observed, severe (grade 4) toxicities including neutropenia, myalgia, fatigue, depression, and other neurologic toxicities occurred in 11.4% of those randomly assigned to interferon treatment. CONCLUSION: Adjuvant treatment with interferon did not contribute to survival or relapse-free survival in this group of patients. 相似文献
23.
24.
25.
26.
A 37-year-old male with history of alcohol abuse presented to us with nausea, vomiting, and abdominal pain with ascites. He was diagnosed with alcoholic liver disease with coagulopathy and pancreatitis. During hospitalization, the patient developed intra-abdominal hemorrhage. He was treated with platelets, packed red blood cells and fresh frozen plasma without any improvement. Following this he was treated with activated recombinant factor VII (90 microg/kg), which resulted in normalization of the prothrombin time and the activated partial thromboplastin time and stabilization of hematocrit within a few hours. We review the current literature on the approved and off-label use of activated recombinant factor VII. 相似文献
27.
28.
Basil D'Souza George Dimitroulis 《Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics》2007,104(4):e59-e61
This is a case study of a patient with recurrent synovial chondromatosis. It shows some relevant images. It also provides possibilities for why this patient may have had a recurrence and how this was managed. 相似文献
29.
George A Kaysen 《Journal of renal nutrition》2007,17(1):4-8
Cardiovascular risk increases with each decrement in renal function. Low-density lipoprotein (LDL) cholesterol levels are not associated with increased mortality, but high-density lipoprotein (HDL) levels are inversely associated with cardiovascular risk. Lipoprotein composition with increased abundance of small dense LDL and HDL and reduced levels of more buoyant isoforms is similar to what is found in states of insulin resistance and in the metabolic syndrome (MS). In both cases, high triglyceride levels are associated with reduced HDL levels. Chronic kidney disease (CKD) is itself associated with increasing insulin resistance as renal function fails. In both instances, decreased levels of apo A-I and apo A-II are a consequence of increased fractional catabolic rate (FCR), resulting from a predominance of small HDL particles. HDL maturation is impaired in CKD through decreased activity of lecithin:cholesterol acyltransferase (LCAT), and increased cholesterol ester transfer protein (CETP) activity in MS shuttles triglycerides back into HDL, thereby destabilizing it. Whether insulin resistance is entirely responsible for disorders of HDL metabolism in CKD, or whether the process is a result of unrelated pathophysiology, is currently unknown. 相似文献
30.
Decreased caloric intake in normal-weight patients with bulimia: comparison with female volunteers 总被引:1,自引:0,他引:1
H E Gwirtsman W H Kaye E Obarzanek D T George D C Jimerson M H Ebert 《The American journal of clinical nutrition》1989,49(1):86-92
Patients with bulimia (binge-purge syndrome) frequently complain that they consume a very restrictive diet to avoid gaining weight. To investigate this claim, 23 hospitalized bulimic patients were assessed daily for body weight, caloric intake, macronutrient diet content, activity measures, and body composition estimates during weight-stable periods. Bulimic patients ate fewer kilocalories per kilogram body weight (22.1 +/- 4.6 kcal/kg) than did age-matched normal women (29.7 +/- 6.5 kcal/kg) but had similar activity levels and body composition. Clinical variables, such as history of laxative abuse, anorexia, or obesity, and physiological characteristics, such as body weight, activity level, or dietary content, could not account for this difference in caloric consumption. Bulimic patients tended to eat a diet lower in fat and higher in protein than did control subjects. These results agree with observations of increased efficiency of caloric utilization in obese patients and support patient complaints of a tendency to gain weight easily. 相似文献