全文获取类型
收费全文 | 1752篇 |
免费 | 89篇 |
国内免费 | 20篇 |
专业分类
耳鼻咽喉 | 21篇 |
儿科学 | 47篇 |
妇产科学 | 78篇 |
基础医学 | 130篇 |
口腔科学 | 63篇 |
临床医学 | 109篇 |
内科学 | 393篇 |
皮肤病学 | 35篇 |
神经病学 | 28篇 |
特种医学 | 74篇 |
外国民族医学 | 2篇 |
外科学 | 483篇 |
综合类 | 19篇 |
一般理论 | 2篇 |
预防医学 | 69篇 |
眼科学 | 49篇 |
药学 | 108篇 |
中国医学 | 4篇 |
肿瘤学 | 147篇 |
出版年
2024年 | 1篇 |
2023年 | 32篇 |
2022年 | 68篇 |
2021年 | 114篇 |
2020年 | 62篇 |
2019年 | 80篇 |
2018年 | 112篇 |
2017年 | 67篇 |
2016年 | 58篇 |
2015年 | 55篇 |
2014年 | 81篇 |
2013年 | 99篇 |
2012年 | 152篇 |
2011年 | 174篇 |
2010年 | 99篇 |
2009年 | 74篇 |
2008年 | 78篇 |
2007年 | 67篇 |
2006年 | 54篇 |
2005年 | 69篇 |
2004年 | 70篇 |
2003年 | 55篇 |
2002年 | 46篇 |
2001年 | 7篇 |
2000年 | 13篇 |
1999年 | 7篇 |
1998年 | 6篇 |
1997年 | 3篇 |
1996年 | 6篇 |
1995年 | 2篇 |
1994年 | 2篇 |
1991年 | 2篇 |
1989年 | 2篇 |
1988年 | 5篇 |
1987年 | 1篇 |
1986年 | 7篇 |
1985年 | 9篇 |
1984年 | 7篇 |
1983年 | 4篇 |
1982年 | 3篇 |
1981年 | 1篇 |
1980年 | 2篇 |
1977年 | 2篇 |
1976年 | 1篇 |
1965年 | 2篇 |
排序方式: 共有1861条查询结果,搜索用时 0 毫秒
21.
Persistent urinary tract infections (UTIs) present a common and challenging problem for both primary care and urologists. They are either the result of bacterial reinfection or persistence, and the management varies depending on the underlying cause. Appropriate investigations are crucial in ruling out any underlying urinary tract abnormalities and identifying the causative organism. We review the underlying pathophysiology and up-to-date management strategies available to the practising urologist. 相似文献
22.
23.
Aim
To compare the value of Procalcitonin (PCT) as a marker of surgical site infection to other inflammatory markers, including C-Reactive Protein (CRP), White Cell Count (WCC) and Erythrocyte Sedimentation Rate (ESR) in patients undergoing a number of spinal procedures. This study also aims to describe the biokinetic profile of the above-named markers in patients developing surgical site infection and those remaining infection-free post-operatively.Methods
200 patients undergoing four routine elective spinal procedures were included for analysis. All patients had blood specimens taken at baseline, day 1, 2, 3, 4 and 5 post-operatively for analysis of PCT, CRP, ESR and WCC levels. All patients were monitored for early surgical site infection. Patients with other sources of infection in the early postoperative period were excluded.Results
Procalcitonin was the most sensitive and specific marker for the detection of surgical site infection in the immediate post-operative period with sensitivity and specificity of 100% and 95.2% respectively. Although Procalcitonin is an inflammatory marker, extent of surgical physiological insult did not alter its biokinetics as opposed to the other inflammatory markers making it a valuable marker of infection.Conclusion
Procalcitonin was found to be superior to the other inflammatory markers investigated in this study as a marker for early surgical site infection in patients undergoing spinal surgery. 相似文献24.
25.
Amr M. Ajlan Ana Maria BilawichNestor L. Müller MD PhD 《Journal l'Association canadienne des radiologistes》2012
The purpose of this article is to illustrate the various manifestations that can be encountered on thoracic computed tomography of tuberous sclerosis in adults. The pulmonary findings include lymphangioleiomyomatosis and multifocal micronodular pneumocyte hyperplasia. The extrapulmonary manifestations are divided into cardiac, vascular, mediastinal, osseous, and upper abdominal findings. 相似文献
26.
Sameh El Noamani Amr M. Thabet Ashraf A. Enab Osama Shaeer Ahmad El-Sadat 《The journal of sexual medicine》2010,7(6):2273-2279
IntroductionGynecomastia denotes benign enlargement of the male breast. It is a common belief that gynecomastia is stigmatizing and may frequently cause social embarrassment and psychological stress. It is possible that this may reflect on erectile function of the afflicted. High grade gynecomastia requires radical breast tissue excision and skin reduction ending up in aesthetically unappealing scars.AimThe purpose of this study is to evaluate the reduction mammaplasty using no vertical scar technique in males with high grade gynecomastia; as regards technical refinements and outcome in the hope of providing a cosmetically appealing solution to this condition. This study also reports on the effect of high grade gynecomastia on erectile function, as well as the effect of surgery.MethodsFifteen male patients with gynecomastia underwent breast reduction using the “no vertical scar reduction mammaplasty.” Erectile function was evaluated before and after surgery.Main Outcome MeasuresSurgical outcome and erectile function.ResultsAll patients but one were satisfied with the outcome. Complications were minimal and manageable. Eleven out of 15 patients had a preoperative International Index of Erectile Function (IIEF) score less than 20 denoting erectile dysfunction. All but one (n = 10) showed improvement in their IIEF score following surgery. The difference between pre-operative IIEF (average 17.8) and postoperative (average 23.5) was statistically significant.ConclusionsThe “no vertical scar reduction mammaplasty” is a reliable technique in cases with gynecomastia and significant ptosis. It has the added benefits of avoiding the vertical scar, hiding the transverse scar in the shadow of the inferior aspect of the breast, with minimal complications. Gynecomastia as a condition causing a feminized outlook may have a negative impact on self confidence and body image. We suggest that this may have a potential negative effect on erectile function, that can be improved by adequate surgical correction. El Noamani S, Thabet AM, Enab AA, Shaeer O, and El-Sadat A. High grade gynecomastia: Surgical correction and potential impact on erectile function. 相似文献
27.
28.
Ryan Webb Matlock Jeffries Amr H. Sawalha 《The American journal of the medical sciences》2009,337(1):23-27
BackgroundAbnormally high serum uric acid levels have been associated with several disease conditions including gout and kidney stone disease. More recently, it was shown that uric acid crystals stimulate dendritic cell maturation, activate the NALP3 inflammasome, and enhance antigen-specific immune responses. We hypothesize that uric acid can also stimulate T cells directly and in the absence of antigen presentation.MethodsPurified primary human T cells were incubated with and without uric acid at concentrations of 50, 100, 150, and 200 μg/mL. The expression of T-cell activation markers CD25 and CD70 was assessed by flow cytometry. In other experiments, Jurkat T cells were used and the expression of the costimulatory molecule CD70 was determined at the mRNA level.ResultsUric acid directly activates primary human T cells in the absence of antigen presentation. Furthermore, primary human T cells and Jurkat T cells treated with uric acid overexpress the costimulatory molecule CD70, which plays an important role in T cell-B cell interaction and antibody production.ConclusionsThe finding that uric acid directly promotes T-cell activation in an antigen-independent system is novel and might play a mechanistic role in the inflammatory response observed in gouty arthritis and other immune-mediated diseases. 相似文献
29.
Preben Bjerregaard Amr El‐Shafei Susan L. Kotar Arthur J. Labovitz 《Annals of noninvasive electrocardiology》2003,8(3):200-207
Background: There has been a renewed interest in ST segment analysis by Holter Monitoring, especially in multicenter clinical trials, but consensus on how to define an ischemic event is missing. We conducted a survey of European and U.S. publications involving ST segment analysis by Holter monitoring from 1975 to 2002 and found no notation of any correction for baseline ST segment depression in 52% of them. In 45% J‐point depression was required in addition to ST segment depression measured either 60 ms (24%) or 80 ms (76%) after the J point. In 28% ST segment elevations were included. Method: Four different criteria for an ischemic event found in our survey were applied to Holter recordings from 66 patients with acute ischemic syndrome enrolled in the Esmolol Myocardial Ischemia Trial (EMIT). Only lead CM5 was used and the analyzer was a Reynolds Medical Pathfinder 600. Results: By the most sensitive method (J + 80) , there were 16 (24%) patients who had ischemic events in their Holter recording compared to only 10 (15%) patients if J‐point depression was also required. If corrections were made for baseline ST segment depression, only 3 (4.5%) recordings were positive for ischemia. Conclusion: The outcome of Holter analysis for ischemic events is greatly dependent upon how an ischemic event is defined. Consensus on how to define an ischemic event is urgently needed. 相似文献
30.