全文获取类型
收费全文 | 698篇 |
免费 | 35篇 |
国内免费 | 2篇 |
专业分类
儿科学 | 8篇 |
妇产科学 | 10篇 |
基础医学 | 105篇 |
口腔科学 | 10篇 |
临床医学 | 58篇 |
内科学 | 124篇 |
皮肤病学 | 55篇 |
神经病学 | 33篇 |
特种医学 | 7篇 |
外科学 | 44篇 |
综合类 | 4篇 |
预防医学 | 165篇 |
眼科学 | 17篇 |
药学 | 40篇 |
中国医学 | 6篇 |
肿瘤学 | 49篇 |
出版年
2024年 | 2篇 |
2023年 | 7篇 |
2022年 | 16篇 |
2021年 | 25篇 |
2020年 | 12篇 |
2019年 | 16篇 |
2018年 | 22篇 |
2017年 | 17篇 |
2016年 | 19篇 |
2015年 | 19篇 |
2014年 | 26篇 |
2013年 | 44篇 |
2012年 | 69篇 |
2011年 | 69篇 |
2010年 | 49篇 |
2009年 | 35篇 |
2008年 | 40篇 |
2007年 | 53篇 |
2006年 | 49篇 |
2005年 | 31篇 |
2004年 | 34篇 |
2003年 | 28篇 |
2002年 | 32篇 |
2001年 | 6篇 |
2000年 | 2篇 |
1999年 | 3篇 |
1998年 | 1篇 |
1997年 | 2篇 |
1996年 | 3篇 |
1995年 | 2篇 |
1994年 | 1篇 |
1988年 | 1篇 |
排序方式: 共有735条查询结果,搜索用时 15 毫秒
131.
O. Gharbi A. Ladhari S. Gahbiche I. Chabchoub L. Amel B. F. Leila H. Makram K. Hedi B. A. Slim 《Journal africain du cancer / African Journal of Cancer》2009,1(3):130-134
Introduction
The aim of this study was to report the frequency and reasons for the use of complementary medicine in patients with cancer, treated in one Tunisian oncology department.Patients and methods
A questionnaire was completed by a person not involved in the treatment, who questioned patients during follow-up or treatment in one oncology department. One hundred fifty questionnaires could be analysed.Results
Forty-nine percent of patients were using complementary medicine. Traditional herbal medicines, a honey and black seed mixture and snake meat were the main substances used. The user profile type was young women, and their main reason for using complementary medicine was to cure cancer. Ninety percent of complementary medicine users did not reveal their habits to their oncologist. Most patients were using complementary medicine during their treatment. 相似文献132.
Slah Ouerhani Kamel Rouissi Raja Marrakchi Mohamed R. Ben Slama Mohamed Sfaxi Mohamed Chebil Amel Benammar ElGaaied 《Cancer Detection and Prevention》2009,32(5-6):395-402
Background: Cigarette smoking is the predominant risk factor for bladder cancer. This risk may be modified by polymorphisms in carcinogens metabolism genes; including those involving the N-acetyl transferase 2 (NAT2) which have been correlated with decreased enzyme activities. Moreover, folate insufficiency can induces carcinogenesis by decreasing DNA methylation. Methylenetetrahydrofolate reductase (MTHFR) and methionine synthase (MTR) are enzymes that play central roles in the folate metabolic pathway. The MTHFR 677*T and MTR 2756*G variants are associated with decreased enzyme activity. Methods: In this work, we have conducted a case-control study in order to assess the combined effect of tobacco, slow NAT2 variants, MTHFR 677*T and MTR 2756*G alleles on bladder cancer development in North Tunisia. Results: For MTR A2756G, alleles and genotypic distributions differed significantly between cases and controls (p = 0.00009, OR = 3.27, CI 95% 1.76–6.12). While, in non-smokers patients the slow NAT2 did not appear to influence bladder cancer susceptibility; our results suggested that it might act with an additive contribution with tobacco as well as with that determined by MTR 2756 AG or 2756 GG genotypes (p = 0.0008). Identical cumulative effect was detected for slow NAT2 and MTHFR 677*T variant (p = 0.0003; OR = 36.6; CI 95% 3.4–935.3). Conclusion: The strongest result obtained by this study was for an additive effect between smoking status, slow NAT2 variants, MTR 2756*G and MTHFR 677*T alleles, in affecting bladder cancer risk. 相似文献
133.
Bougatef K Marrakchi R Moussa A Blondeau-Lahely Y Najjar T Coulet F Colas C Ben Ayed F Ben Ammar Elgaaied A Soubrier F 《Oncology reports》2008,19(5):1213-1218
Familial adenomatous polyposis (FAP) is an autosomal dominant inherited disease characterized by the development of hundreds to thousands of adenomatous polyps in colon and rectum. The APC gene (adenomatous polyposis coli) is considered as the major mutated gene in FAP. It has been shown that biallelic germline mutations in the base-excision-repair gene MYH can be responsible for a recessive inheritance of adenomatous polyposis (AP). This study is the first Tunisian genetic analysis on AP patients. Multiplex ligation-dependent probe amplification (MLPA) was used to screen the APC gene for large genomic rearrangements. The total APC and MYH exon sequences and exon-intron edges were sequenced in an effort to detect germline mutations, four were explored. Mutations were detected in four patients that fulfil the clinical criteria of AP. Three mutations were found in the APC gene, of which two were novel (c.1636_1639delAGTG and c.2514 G>T) and all gave rise to a truncated APC protein. The missense G382D mutation, already described in north and south European populations was found in the MYH gene at the homozygous state in the fourth patient with moderate AP. Our preliminary study provides a basis for implementation of genetic counselling for AP. 相似文献
134.
135.
136.
Laurel Young Amel Katrib Carolyn Cuello Ute Vollmer‐Conna James V. Bertouch Peter J. Roberts‐Thomson Michael J. Ahern Malcolm D. Smith Peter P. Youssef 《Arthritis \u0026amp; Rheumatology》2001,44(2):343-350
Objective
To investigate the effects of intraarticular glucocorticoid treatment on macrophage infiltration, the expression of the chemokines monocyte chemoattractant protein 1 (MCP‐1) and macrophage inflammatory protein 1α (MIP‐1α), and the expression of matrix metalloproteinases 1 and 3 (MMPs 1 and 3) and their inhibitors, the tissue inhibitors of metalloproteinases 1 and 2 (TIMPs 1 and 2), in osteoarthritis (OA) synovial membranes.Methods
Forty patients underwent arthroscopic biopsy before and 1 month after intraarticular injection of glucocorticoids. Twenty‐one patients received 120 mg of methylprednisolone acetate (Depo‐Medrol; Upjohn, Kalamazoo, MI), and 20 patients received placebo (1 patient received placebo in 1 knee and methylprednisolone acetate in the other). Immunoperoxidase staining for the expression of CD68, MCP‐1, MIP‐1α, MMP‐1, MMP‐3, TIMP‐1, and TIMP‐2 was performed, and the immunostaining was quantified by color video image analysis.Results
CD68, MCP‐1, MIP‐1α, MMP‐1, MMP‐3, TIMP‐1, and TIMP‐2 immunostaining was observed in all synovial membranes. Intraarticular glucocorticoid treatment was associated with a small (30%) but statistically significant (P = 0.048) reduction in CD68+ macrophage staining in the synovial lining layer, but there was no change in the CD68 expression in the synovial sublining layer. No significant differences were observed for MCP‐1, MIP‐1α, MMP‐1, MMP‐3, TIMP‐1, and TIMP‐2 immunostaining in the synovial lining or sublining layers.Conclusion
Intraarticular glucocorticoids may reduce CD68+ macrophage infiltration into the synovial lining layer, but not the expression of MCP‐1, MIP‐1α, MMP‐1, MMP‐3, TIMP‐1, and TIMP‐2 in the synovial membrane, in patients with OA.137.
Forugh Vaziri Sani Vesa Kaartinen Maha El Shahawy Anders Linde Amel Gritli‐Linde 《European journal of oral sciences》2010,118(3):221-236
Vaziri Sani F, Kaartinen V, El Shahawy M, Linde A, Gritli‐Linde A. Developmental changes in cellular and extracellular structural macromolecules in the secondary palate and nasal cavity of the mouse. Eur J Oral Sci 2010; 118: 221–236. © 2010 The Authors. Journal compilation© 2010 Eur J Oral Sci The aim of this study was to analyse the hitherto largely unknown expression patterns of some specific cellular and extracellular molecules during palate and nasal cavity development. We showed that epithelia of the developing palate and the vomerine epithelium express similar sets of structural proteins. With the exception of keratin 15, which becomes barely detectable in the elevated palatal shelves, nearly all of these proteins become upregulated at the presumptive areas of fusion and in the adhering epithelia of the palate and nasal septum. In vivo and in vitro analyses indicated that reduction in the amount of keratin 15 protein is independent of Tgfβ–Alk5 signalling. Foxa1 expression also highlighted the regionalization of the palatal and nasal epithelia. Owing to the lack of reliable markers of the palatal periderm, the fate of peridermal cells has been controversial. We identified LewisX/stage‐specific embryonic antigen‐1 as a specific peridermal marker, and showed that numerous peridermal cells remain trapped in the medial epithelial seam (MES). The fate of these cells is probably apoptosis together with the rest of the MES cells, as we provided strong evidence for this event. Heparan sulphate, chondroitin‐6‐sulphate, and versican displayed dynamically changing distribution patterns. The hitherto‐unknown innervation pattern of the developing palate was revealed. These findings may be of value for unravelling the pathogenesis of palatal clefting. 相似文献
138.
Rachida Raache Khadidja Belanteur Habiba Amroun Amel Benyahia Amel Heniche Malha Azzouz Safia Mimouni Thibaud Gervais Dominique Latinne Aissa Boudiba Nabila Attal Mohamed Cherif Abbadi 《Clinical and Vaccine Immunology : CVI》2012,19(4):557-561
Major histocompatibility complex class I chain-related gene A (MICA-129) dimorphism was investigated in 73 autoimmune diabetes patients (type 1 diabetes and latent autoimmune diabetes in adults) and 75 controls from Algeria. Only MICA-129 Val allele and MICA-129 Val/Val genotype frequencies were higher among patients than in the control group. Statistical analysis of the estimated extended HLA-DR-DQ-MICA haplotypes shown that individual effects of MICA alleles on HLA-DQ2-DR3-MICA-129 Val/Val and HLA-DQ8-DR4-MICA-129 Val/Val haplotypes were significantly higher in patients than in the control groups. These preliminary data might suggest a relevant role of MICA-129 Val/Val single nucleotide polymorphism (weak/weak binders of NKG2D receptor) in the pathogenesis of T1D and LADA. 相似文献
139.
Chayma Bouaziz Amel Bouslimi Rabiaa Kadri Chiraz Zaied Hassen Bacha Salwa Abid-Essefi 《Experimental and toxicologic pathology》2013,65(5):497-501
The aim of the present study was to investigate in vitro, whether cytolethality and oxidative damage is enhanced by combination of both mycotoxins as compared to their individual effect. In our paper, we applied a tiered in vitro experimental approach in order to predict the possible health risk effects of two interactive fusarial toxins. Considering the concomitant production of zearalenone (ZEN) and T-2 toxin, it is very likely that humans and animals are always exposed to the mixture rather than to individual compounds.Our results clearly showed that cultured renal cells respond to individual (ZEN) or T-2 toxin exposure by a moderate inhibition of cell proliferation, respectively. However, when combined, they exert a more significant decrease in cell viability. Similar results were found for the investigated oxidative status endpoints. When combined, ZEN and T-2 toxin increased ROS production and heat shock protein (Hsp) 70 expression as compared to the effect of each mycotoxin taken alone.We can conclude that the mixture of ZEN and T-2 toxin increased their toxic effects. The health risk is heightened by the interactions between co-occurring mycotoxins. 相似文献