全文获取类型
收费全文 | 3918篇 |
免费 | 225篇 |
国内免费 | 16篇 |
专业分类
耳鼻咽喉 | 25篇 |
儿科学 | 103篇 |
妇产科学 | 60篇 |
基础医学 | 467篇 |
口腔科学 | 188篇 |
临床医学 | 305篇 |
内科学 | 955篇 |
皮肤病学 | 52篇 |
神经病学 | 421篇 |
特种医学 | 68篇 |
外科学 | 544篇 |
综合类 | 37篇 |
一般理论 | 1篇 |
预防医学 | 302篇 |
眼科学 | 47篇 |
药学 | 204篇 |
中国医学 | 17篇 |
肿瘤学 | 363篇 |
出版年
2024年 | 3篇 |
2023年 | 16篇 |
2022年 | 45篇 |
2021年 | 108篇 |
2020年 | 72篇 |
2019年 | 132篇 |
2018年 | 133篇 |
2017年 | 71篇 |
2016年 | 61篇 |
2015年 | 100篇 |
2014年 | 137篇 |
2013年 | 165篇 |
2012年 | 312篇 |
2011年 | 315篇 |
2010年 | 158篇 |
2009年 | 153篇 |
2008年 | 284篇 |
2007年 | 278篇 |
2006年 | 295篇 |
2005年 | 279篇 |
2004年 | 241篇 |
2003年 | 195篇 |
2002年 | 197篇 |
2001年 | 31篇 |
2000年 | 36篇 |
1999年 | 35篇 |
1998年 | 29篇 |
1997年 | 24篇 |
1996年 | 21篇 |
1995年 | 32篇 |
1994年 | 19篇 |
1993年 | 22篇 |
1992年 | 26篇 |
1991年 | 20篇 |
1990年 | 12篇 |
1989年 | 8篇 |
1988年 | 5篇 |
1987年 | 5篇 |
1986年 | 7篇 |
1985年 | 5篇 |
1984年 | 8篇 |
1983年 | 11篇 |
1982年 | 5篇 |
1981年 | 13篇 |
1980年 | 7篇 |
1975年 | 2篇 |
1973年 | 5篇 |
1972年 | 2篇 |
1971年 | 3篇 |
1970年 | 2篇 |
排序方式: 共有4159条查询结果,搜索用时 31 毫秒
71.
72.
de Lima Silva Alvaro Henrique Bernardo Radulski Debora Rasec Pereira Gabriela Saidel Acco Alexandra Zanoveli Janaina Menezes 《Metabolic brain disease》2022,37(4):1095-1110
Metabolic Brain Disease - Anxiety Disorders and Posttraumatic Stress Disorders (PTSD) associated with type-1 diabetes mellitus (T1DM) are increasingly common comorbidities and the treatment is... 相似文献
73.
Age Progression of Neuropathological Markers in the Brain of the Chilean Rodent Octodon degus,a Natural Model of Alzheimer's Disease 下载免费PDF全文
Nibaldo C. Inestrosa Juvenal A. Ríos Pedro Cisternas Cheril Tapia‐Rojas Daniela S. Rivera Nady Braidy Juan M. Zolezzi Juan A. Godoy Francisco J. Carvajal Alvaro O. Ardiles Francisco Bozinovic Adrián G. Palacios Perminder S. Sachdev 《Brain pathology (Zurich, Switzerland)》2015,25(6):679-691
Alzheimer's disease (AD) is the most common neurodegenerative disorder and the leading cause of age‐related dementia worldwide. Several models for AD have been developed to provide information regarding the initial changes that lead to degeneration. Transgenic mouse models recapitulate many, but not all, of the features of AD, most likely because of the high complexity of the pathology. In this context, the validation of a wild‐type animal model of AD that mimics the neuropathological and behavioral abnormalities is necessary. In previous studies, we have reported that the Chilean rodent Octodon degus could represent a natural model for AD. In the present work, we further describe the age‐related neurodegeneration observed in the O. degus brain. We report some histopathological markers associated with the onset progression of AD, such as glial activation, increase in oxidative stress markers, neuronal apoptosis and the expression of the peroxisome proliferative‐activated receptor γ coactivator‐1α (PGC‐1α). With these results, we suggest that the O. degus could represent a new model for AD research and a powerful tool in the search for therapeutic strategies against AD. 相似文献
74.
Anastos K Barrón Y Miotti P Weiser B Young M Hessol N Greenblatt RM Cohen M Augenbraun M Levine A Muñoz A;Women's Interagency HIV Study Collaborative Study Group 《Archives of internal medicine》2002,162(17):1973-1980
BACKGROUND: The optimal virologic and immunologic stage at which to initiate antiretroviral therapy in individuals infected with human immunodeficiency virus type 1 (HIV-1) is undefined. METHODS: Among 1054 HIV-1-infected women in a prospective cohort study, we determined the time from initiation of highly active antiretroviral treatment (HAART) to acquired immunodeficiency syndrome (AIDS) and death. RESULTS: Median follow-up was 3.4 years. Of 553 women without AIDS at HAART initiation, 62 (11%) developed AIDS. Compared with women with CD4(+) cell counts greater than 350/microL at HAART initiation, women with cell counts of 200 to 350/microL and less than 200/microL had relative hazards (RHs) for progression to AIDS of 0.93 (95% confidence interval [CI], 0.46-1.86) and 2.48 (95% CI, 1.39-4.42), respectively. Compared with those with HIV-1 RNA values less than 5000 copies/mL, women with 5000 to 50,000 copies/mL and greater than 50,000 copies/mL had RHs of 1.39 (95% CI, 0.74-2.64) and 2.09 (95% CI, 1.09-3.99), respectively. Among women with AIDS at HAART initiation (n = 501), RHs of death were 1.97 (95% CI, 0.84-4.66) and 3.35 (95% CI, 1.59-7.08) with CD4(+) cell counts of 200 to 350/microL and less than 200/microL, respectively, relative to those with greater than 350/microL, and 1.90 (95% CI, 0.84-4.30) and 3.70 (95% CI, 1.81-7.54) for those with HIV-1 RNA values of 5000 to 50,000 and greater than 50,000 copies/mL, respectively, relative to those with less than 5000 copies/mL. CONCLUSIONS: Progression to AIDS and death was predicted by pre-HAART values of less than 200/microL for CD4(+) cells and greater than 50,000 HIV-1 RNA copies/mL, indicating that deferral of HAART until the CD4(+) cell count is between 350 and 200/microL is a valid strategy in the clinical management of HIV-1 infection. 相似文献
75.
76.
77.
A study of prognostic factors in blast crisis of Philadelphia chromosome-positive chronic myelogenous leukaemia 总被引:1,自引:0,他引:1
Francisco Cervantes María Rozman Jordi Rosell Alvaro Urbano-Ispizua† Emilio Montserrat Ciril Rozman 《British journal of haematology》1990,76(1):27-32
In 80 patients with Ph-positive chronic myelogenous leukaemia the main clinical, haematological and cytogenetical data were recorded at diagnosis of blast crisis and evaluated for prognostic significance. At the time of the analysis 73 patients had died, with a median survival of 4-8 months from diagnosis of blast crisis for the whole series. When analysed as a time-dependent variable, the achievement of a favourable response to chemotherapy resulted in a longer patient's survival. On the other hand, the univariate analysis identified six pretreatment characteristics associated with a poorer prognosis: a longer chronic phase, presence of extramedullary blastic involvement, a platelet count below 200 x 10(9)/l, a less marked leucocytosis, a blood blast cell percentage higher than 10%, and presence of trisomy 8. The latter parameters were included in a multiple regression model together with the blast cell phenotype (lymphoid versus non-lymphoid), and only four of them (trisomy 8, duration of chronic phase, platelet count, and leucocyte count) retained their prognostic influence. When the therapeutical response was also included in the regression model, it proved to be the most important prognostic variable, followed by trisomy 8, length of chronic phase, extramedullary disease, and platelet count, whereas the leukocyte count lost its predictive value. Thus, in spite of the short overall survival of blast crisis patients, the identification of prognostic factors in such a haematological condition may be of interest, especially in the interpretation of new therapeutical approaches. 相似文献
78.
79.
Mosso L Carvajal C González A Barraza A Avila F Montero J Huete A Gederlini A Fardella CE 《Hypertension》2003,42(2):161-165
Recent studies in hypertensive populations that have used the serum aldosterone (SA) to plasma renin activity (PRA) ratio as a screening test have demonstrated a high prevalence of primary aldosteronism (PA). This frequency is higher than that previously described when hypokalemia was used as a screening tool. However, other factors, such as the characteristics of hypertensive disease, could also influence the prevalence of PA. We studied 609 essential hypertensive patients, classified according to the Joint National Committee VI (JNC VI), in 3 different stages depending on the severity of their hypertensive disease. We measured SA and PRA and calculated the SA-PRA ratio for all patients. An SA-PRA ratio >25 was detected in 63 of 609 patients, and the fludrocortisone test confirmed the PA diagnoses in 37 of 609 (6.1%) cases. PA prevalence according to hypertension stage was as follows: stage 1, 6 of 301 cases (1.99%); stage 2, 15 of 187 cases (8.02%); and stage 3, 16 of 121 cases (13.2%). PA patients were slightly younger than the other hypertensive patients (48.4+/-10.5 vs 53.6+/-10.2 years; P<0.05). Serum potassium levels were normal in 36 of 37 PA patients; only 1 patient had minor hypokalemia. Computed tomography scans showed bilateral adrenal enlargement in 7 and an adrenal nodule in 2 cases. In summary, we found a high frequency of PA in essential hypertensives classified in stages 2 and 3 according to the JNC VI. The low frequency of computed tomography scan abnormalities and hypokalemia suggests that the diagnosis for most PA patients corresponds to attenuated forms of the disease. 相似文献
80.
The immunoprevention of cancer and cancer recurrence is an important area of concern for the scientific community and society as a whole. Researchers have been working for decades to develop vaccines with the potential to alleviate these health care and economic burdens. So far, vaccines have made more progress in preventing cancer than in eliminating already established cancer. In particular, vaccines targeting oncogenic viruses, such as the human papillomavirus and the hepatitis B virus, are exceptional examples of successful prevention of virus-associated cancers, such as cervical cancer and hepatocellular carcinoma. Cancer-preventive vaccines targeting nonviral antigens, such as tumor-associated antigens and neoantigens, are also being extensively tested. Here, we review the currently approved preventive cancer vaccines; discuss the challenges in this field by covering ongoing preclinical and clinical human trials in various cancers; and address various issues related to maximizing cancer vaccine benefit. 相似文献