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Joseph Brunworth MD Vikram Padhye MBBS Ahmed Bassiouni MBBCh Alkis Psaltis MBBS PhD FRACS Stephen Floreani MBBS FRACS Simon Robinson MBChB FRACS Stephen Santoreneos MBBS FRACS Nick Vrodos MBBS FRACS Andrew Parker MBBS FRACS Agadha Wickremesekera MBChB FRACS MD Peter-John Wormald MBChB FCS FRCS FRACS 《International forum of allergy & rhinology》2015,5(4):344-352
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Jake Jervis Bardy Derek S Sarovich Erin P Price Eike Steinig Steven Tong Amanda Drilling Judy Ou Sarah Vreugde Peter-John Wormald Alkis J Psaltis 《BMC ear, nose, and throat disorders》2018,18(1):16
Background
Staphylococcus aureus has a high prevalence in chronic rhinosinusitis (CRS) patients and is suggested to play a more etiopathogenic role in CRS patients with nasal polyps (CRSwNP), a severe form of the CRS spectrum with poorer surgical outcomes. We performed a microbial genome-wide association study (mGWAS) to investigate whether S. aureus isolates from CRS patients have particular genetic markers associated with CRS with nasal polyps (CRSwNP) or CRS without nasal polyps (CRSsNP).Methods
Whole genome sequencing was performed on S. aureus isolates collected from 28 CRSsNP and 30 CRSwNP patients. A mGWAS approach was employed using large-scale comparative genomics to identify genetic variation within our dataset.Results
Considerable genetic variation was observed, with >?90,000 single nucleotide polymorphisms (SNPs) sites identified. There was little correlation with CRS subtype based on SNPs and Insertion/Delection (Indels). One indel was found to significantly correlate with CRSwNP and occurred in the promoter region of a bacitracin transport system ATP-binding protein. Additionally, two variants of the highly variable superantigen-like (SSL) proteins were found to significantly correlate with each CRS phenotype. No significant association with other virulence or antibiotic resistance genes were observed, consistent with previous studies.Conclusion
To our knowledge this study is the first to use mGWAS to investigate the contribution of microbial genetic variation to CRS presentations. Utilising the most comprehensive genome-wide analysis methods available, our results suggest that CRS phenotype may be influenced by genetic factors other than specific virulence mechanisms within the S. aureus genome.46.
Staphylococcus Aureus V8 protease disrupts the integrity of the airway epithelial barrier and impairs IL‐6 production in vitro
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Amanda K. Rudman Spergel Michael Minnicozzi Lisa M. Wheatley Alkis Togias 《Current allergy and asthma reports》2018,18(9):47
Purpose of Review
Although evidence supports a beneficial effect of allergen immunotherapy on the symptoms of allergic respiratory disease and food allergy, it is not clear whether immunotherapy modifies the natural history of these conditions.Recent Findings
In aeroallergen immunotherapy, studies suggest that prevention of asthma can be attained. Less evident is the ability of immunotherapy to prevent new allergen sensitizations and more studies are needed to test whether immunotherapy can continue suppressing airway symptoms after treatment discontinuation. In food allergen immunotherapy, there is evidence that unresponsiveness to a food challenge can be sustained in some treatment recipients, but little knowledge exists as to the dose and duration of treatment that can optimize this effect.Summary
Suggestive evidence exists that allergen immunotherapy can modify allergic disease in children, but definitive studies are lacking. More research in the field is required.48.
49.
Successful repair of intraoperative cerebrospinal fluid leaks improves outcomes in endoscopic skull base surgery
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Arash Shahangian MD PhD Zachary M. Soler MD Andrew Baker MD Sarah K. Wise MD Shruthi K. Rereddy BS Zara M. Patel MD Nelson M. Oyesiku MD John M. DelGaudio MD Constantinos G. Hadjipanayis MD Bradford A. Woodworth MD Kristen O. Riley MD John Lee MD Michael D. Cusimano MD Satish Govindaraj MD Mohemmed N. Khan MD Alkis Psaltis MD PhD Peter J. Wormald MD Stephen Santoreneos MD Raj Sindwani MD Samuel Trosman MD Janalee K. Stokken MD Troy D. Woodard MD Pablo F. Recinos MD W. Alexander Vandergrift MD III Caitlin Boling BS Rodney J. Schlosser MD 《International forum of allergy & rhinology》2017,7(1):80-86
50.
Discordant frequencies of tissue‐resident and circulating CD180‐negative B cells in chronic rhinosinusitis
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