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Chen Vincent Barker Alex J. Golan Rotem Scott Michael B. Huh Hyungkyu Wei Qiao Sojoudi Alireza Markl Michael 《The international journal of cardiovascular imaging》2021,37(12):3539-3547
The International Journal of Cardiovascular Imaging - Deep learning algorithms for left ventricle (LV) segmentation are prone to bias towards the training dataset. This study assesses sex- and... 相似文献
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Zandieh A Maleki F Hajimirzabeigi A Zandieh B Khalilzadeh O Dehpour AR 《Acta neurobiologiae experimentalis》2010,70(4):390-397
This study aimed to examine whether celecoxib influences clonic seizure thresholds through modulation of nitric oxidergic (NO) pathway. The effect of celecoxib (1-5 mg per kg, p.o.) was investigated on clonic seizures induced by pentylenetetrazole (PTZ, 50 and 80 mg per kg, i.p.) in male Swiss mice. The interaction of celecoxib-induced effects with NO pathway was examined using a NO synthase (NOS) inhibitor, N(G)-omega-nitro-L-arginine methyl ester (L-NAME, 20 and 50 mg per kg, i.p.) and a NOS substrate, L-arginine (100 and 200 mg per kg, i.p.). The criteria for the development of seizure activity were the possibility for appearance of generalized clonus and prolongation of latency to the onset of convulsions following administration of 50 and 80 mg per kg of PTZ, respectively. Pretreatment with celecoxib (2.5 and 5 mg per kg) or L-NAME (50 mg per kg) induced anticonvulsant effect on the PTZ-induced clonic seizures. L-arginine at the dose of 200 mg per kg had proconvulsant effect. A sub-effective dose of celecoxib (1 mg per kg) induced an additive anticonvulsant effect when co-administered with L-NAME (20 mg per kg). Although L-arginine (100 mg per kg) per se did not influence PTZ-induced convulsion, it could attenuate the anticonvulsant effect of celecoxib (5 mg per kg). Our results indicate that celecoxib induces an anticonvulsant effect on clonic seizure threshold that may involve NO pathway. 相似文献
115.
Marita Mohammadshahi Sara Emamgholipour Sefiddashti Minoo Alipouri Sakha Alireza Olyaeemanesh Shahrooz Yazdani 《Indian heart journal》2021,73(3):376-378
The aim of this study was to assess the appropriate use of diagnostic catheterizations (DC) for the patients with suspected coronary artery disease performed in Iran. The Electronic Health Record System database and manual review of files were utilised to collect data between 2012 and 2014. Patients were categorized in three groups as appropriate, uncertain, and inappropriate usage of DC and the logistic regression was used to investigate the relationships between variables. One-quarter of the 2458 angiographies were rated as inappropriate, out of which 99% had no previous stress test. The rate of inappropriate DC between various hospitals were approximately the same. The regression showed that some risk factors (Sex, high cholesterol, smoking, chronic heart failure, renal failure, diabetes) were significantly associated with inappropriate rate. 相似文献
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Bryan Coburn Donald E. Low Samir N. Patel Susan M. Poutanen Dea Shahinas Alireza Eshaghi Barbara M. Willey Allison McGeer 《Journal of clinical microbiology》2014,52(5):1766-1767
We report the emergence of vancomycin resistance in a patient colonized with a vanA-containing, vanRS-negative isolate of Enterococcus faecium which was initially vancomycin susceptible. This is a previously undescribed mechanism of drug resistance with diagnostic and therapeutic implications. 相似文献
118.
Hassan Abolhassani Janet Chou Wayne Bainter Craig D. Platt Mahmood Tavassoli Tooba Momen Marzieh Tavakol Mohammad Hossein Eslamian Mohammad Gharagozlou Masoud Movahedi Mohsen Ghadami Amir Ali Hamidieh Gholamreza Azizi Reza Yazdani Mohsen Afarideh Alireza Ghajar Arash Havaei Zahra Chavoshzadeh Asghar Aghamohammadi 《The Journal of allergy and clinical immunology》2018,141(4):1450-1458
119.
Fatemeh Shabani Alireza Farasat Majid Mahdavi Nematollah Gheibi 《Inflammation research》2018,67(10):801-812
Background
Calprotectin (S100A8/S100A9), a heterodimeric EF-hand Ca2+?binding protein, are abundant in cytosol of neutrophils and are involved in inflammatory processes and several cancerous pathogens.Objective
The purpose of the present systematic review is to evaluate the pro- and anti-tumorigenic functions of calprotectin and its relation to inflammation.Materials and methods
We conducted a review of studies published in the Medline (1966–2018), Scopus (2004–2018), ClinicalTrials.gov (2008–2018) and Google Scholar (2004–2018) databases, combined with studies found in the reference lists of the included studies.Results
Elevated levels of S100A8/S100A9 were detected in inflammation, neoplastic tumor cells and various human cancers. Recent data have explained that many cancers arise from sites of infection, chronic irritation, and inflammation. The inflammatory microenvironment which largely includes calprotectin, has an essential role on high producing of inflammatory factors and then on neoplastic process and metastasis.Conclusion
Scientists have shown different outcomes in inflammation, malignancy and apoptosis whether the source of the aforementioned protein is extracellular or intracellular. These findings are offering new insights that anti-inflammatory therapeutic agents and anti-tumorigenic functions of calprotectin can lead to control cancer development.120.
Mohammad Taghi Palizgir Maryam Akhtari Shayan Mostafaei Alireza Rezaiemanesh 《Immunopharmacology and immunotoxicology》2018,40(4):297-302
Objective: Behcet's disease (BD) is an auto-inflammatory disorder. Curcumin as a bio-active agent has anti-inflammatory properties. Effects of curcumin on the pathogenesis of BD are still not clear. In this study, we investigated the effect of curcumin on the inflammatory cytokines expression and production in M1 macrophages from BD patients compared with healthy controls.Methods: Monocytes were collected from 10 healthy controls and 20 active BD patients, differentiated to macrophages by macrophage-colony stimulating factor for 7?d. Macrophages were then treated with interferon gamma, lipopolysaccharide, and curcumin (10 or 30?µg/ml) for 24?h. Analysis of tumor necrosis factor-alpha (TNFα), interleukin 1β (IL-1β), and IL-6 mRNA expression and protein production was performed using SYBR Green qPCR and ELISA method.Results: Treatment with 30?µg/ml curcumin significantly down-regulated mRNA expression of IL-1β (p?<?.05) and protein production of IL-6 (p?.05) in M1 macrophages from BD patients but not in M1 macrophage from controls. Treatment with 30?µg/ml curcumin also significantly diminishes the protein production of TNFα in BD patients (p?.01) and healthy controls (p?.05) M1 macrophages.Conclusions: We demonstrated that curcumin can inhibit the expression and production of inflammatory cytokines in M1 macrophages from BD patients. Our results suggest that curcumin can modulate inflammatory signaling more specifically in macrophages from BD patients than healthy macrophages. 相似文献