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991.
Joo Ricardo Almeida Grossi Marcelo Parra Ernesto B Benalczar-Jalkh Allan Fernando Giovanini Joo Csar Zielak Aline Monise Sebstiani Carla Castiglia Gonzaga Paulo G Coelho Lukasz Witek Tatiana Miranda Deliberador 《Medicina oral, patología oral y cirugía bucal》2022,27(2):e174
Background The aim of the present study was to evaluate the effect of different concentrations of growth hormone (GH) on endosteal implant’s surface at the early stages of osseointegration.Material and Methods Sixty tapered acid-etched titanium implants were divided into four groups: i) Collagen, used as a control group; and three experimental groups, where after collagen coating, GH was administered directly to the surface in varying concentrations: ii) 0.265 mg, iii) 0.53 mg, and iv) 1 mg. Implants were placed in an interpolated fashion in the anterior flange of C3, C4 or C5 of 15 sheep with minimum distance of 6 mm between implants. After 3-, 6- and 12-weeks of healing samples were harvested, histologically processed, qualitatively and quantitatively assessed for bone-to-implant contact (BIC) and bone area fraction occupancy (BAFO).Results Statistical analysis as a function of time in vivo and coating resulted in no significant differences for BIC and BAFO at any evaluation time point. Histological evaluation demonstrated similar osseointegration features for all groups with woven bone formation at 3 weeks and progressive replacement of woven for lamellar bone in close contact with the implant surface and within the implant’s threads.Conclusions A single local application of growth hormone to the surface of titanium implants did not yield improved implant osseointegration independent of healing time. Key words:Growth hormone, osseointegration, low density bones, metallic implants, sheep, bone-to-implant contact. 相似文献
992.
Blandine de Lauzon‐Guillain Xavier Thierry Corinne Bois Marie Bournez Camille Davisse‐Paturet Marie‐Noëlle Dufourg Claire Kersuzan Ela Ksiazek Sophie Nicklaus Hlne Vicaire Sandra Wagner Sandrine Lioret Marie Aline Charles 《Maternal & child nutrition》2019,15(4)
Previous studies have shown a high level of noncompliance with recommendations on breastfeeding duration, especially in France. The objective was to describe the association between breastfeeding initiation and duration and the statutory duration of postnatal maternity leave, the gap between the end of legal maternity leave and the mother's return to work, and maternal working time during the first year post‐partum. Analyses were based on 8,009 infants from the French nationwide ELFE cohort. We assessed the association with breastfeeding initiation by using logistic regression and, among breastfeeding women, with categories of breastfeeding duration by using multinomial logistic regression. Among primiparous women, both postponing return to work for at least 3 weeks after statutory postnatal maternity leave (as compared with returning to work at the end of the statutory period) and working less than full‐time at 1 year post‐partum (as compared with full‐time) were related to higher prevalence of breastfeeding initiation. Among women giving birth to their first or second child, postponing the return to work until at least 15 weeks was related to a higher prevalence of long breastfeeding duration (at least 6 months) as compared with intermediate duration (3 to <6 months). Working part‐time was also positively related to breastfeeding duration. Among women giving birth to their third child or more, working characteristics were less strongly related to breastfeeding duration. These results support extending maternity leave or working time arrangements to encourage initiation and longer duration of breastfeeding. 相似文献
993.
Laura Aline Mengel Bahareh Nemati Moud Hatti Seidl Alberto Mesas-Fernndez Claudine Seeliger Beate Brandl Thomas Skurk Christina Holzapfel Melina Claussnitzer Hans Hauner 《Obesity facts》2022,15(3):405
IntroductionBrown adipose tissue (BAT) serves to produce heat by nonshivering thermogenesis. Activation of BAT increases energy expenditure and is seen as a putative strategy to treat obesity. There are conflicting data on the capacity for cold-induced thermogenesis in individuals with higher BMI.MethodsTo investigate the effect of BMI on cold-induced stimulation of energy expenditure, changes in the metabolic profile, and the expression of browning markers in subcutaneous white adipose tissue (scWAT), healthy adults (N = 173, 50.9% females) with a median age of 26.0 (interquartile range [IQR]: 23.0; 28.0) years and a median body mass index (BMI) of 23.6 [IQR: 21.9; 26.6] kg/m<sup>2</sup> were exposed to short-term mild cold exposure (CE). Resting energy expenditure (REE) was measured by indirect calorimetry and blood sampling was conducted at baseline and after CE. In a subgroup of participants with obesity, subcutaneous abdominal fat biopsies were taken before and after CE.ResultsThe cold-induced median increase in REE was 74 (IQR: −28; 241) kcal/day (p < 0.001). This increase negatively correlated with BMI (p < 0.001). Participants with BMI 18.5–24.9 kg/m<sup>2</sup> displayed a significant median increase of 103 kcal/day (p < 0.001), participants with overweight or obesity were not able to increase REE (23, p = 0.468 or −30 kcal/day, p = 0.917, respectively). In participants with obesity, expression of cell death activator in scWAT after CE was upregulated in females (p = 0.034).ConclusionsPersons with overweight and obesity do not increase REE in response to CE, presumably reflecting lower BAT activity. Likewise, the metabolic response to cold is diminished in participants with elevated BMI. 相似文献
994.
Aline Renneville Raouf Ben Abdelali Sylvie Chevret Olivier Nibourel Meyling Cheok Cécile Pautas Rémy Duléry Thomas Boyer Jean-Michel Cayuela Sandrine Hayette Emmanuel Raffoux Hassan Farhat Nicolas Boissel Christine Terre Hervé Dombret Sylvie Castaigne Claude Preudhomme 《Oncotarget》2014,5(4):916-932
We recently showed that the addition of fractionated doses of gemtuzumab ozogamicin (GO) to standard chemotherapy improves clinical outcome of acute myeloid leukemia (AML) patients. In the present study, we performed mutational analysis of 11 genes (FLT3, NPM1, CEBPA, MLL, WT1, IDH1/2, RUNX1, ASXL1, TET2, DNMT3A), EVI1 overexpression screening, and 6.0 single-nucleotide polymorphism array (SNP-A) analysis in diagnostic samples of the 278 AML patients enrolled in the ALFA-0701 trial. In cytogenetically normal (CN) AML (n = 146), 38% of the patients had at least 1 SNP-A lesion and 89% of the patients had at least 1 molecular alteration. In multivariate analysis, the independent predictors of higher cumulative incidence of relapse were unfavorable karyotype (P = 0.013) and randomization in the control arm (P = 0.007) in the whole cohort, and MLL partial tandem duplications (P = 0.014) and DNMT3A mutations (P = 0.010) in CN-AML. The independent predictors of shorter overall survival (OS) were unfavorable karyotype (P < 0.001) and SNP-A lesion(s) (P = 0.001) in the whole cohort, and SNP-A lesion(s) (P = 0.006), DNMT3A mutations (P = 0.042) and randomization in the control arm (P = 0.043) in CN-AML. Interestingly, CN-AML patients benefited preferentially more from GO treatment as compared to AML patients with abnormal cytogenetics (hazard ratio for death, 0.52 versus 1.14; test for interaction, P = 0.04). Although the interaction test was not statistically significant, the OS benefit associated with GO treatment appeared also more pronounced in FLT3 internal tandem duplication positive than in negative patients. 相似文献
995.
Katrina Plamondon PhD MSc RN Davina Banner PhD RN Miranda A. Cary PhD Melissa Faulkner RN Heather Gainforth PhD Kiranpreet Ghag Med Alison Hoens MSc BScPT Anne Huisken MSc Damanpreet K. Kandola PhD MSc Shaheer Khan BHK Aline Silveira Silva PhD Nelly Oelke PhD RN Ashmita Rai MSN Kimberly Strain BA Kathryn M. Sibley PhD Ursula Wick 《Health expectations》2024,27(1):e13865
996.
Ezequias B. Martins Fernanda de Bruycker-Nogueira Cintia D. S. Rodrigues Carolina C. Santos Simone A. Sampaio Allison A. Fabri Vinícius Guerra-Campos Maria Anglica M. Mares-Guia Nieli R. C. Faria Aline S. Santos Marcelle A. S. Pinto Michele F. B. Silva Isabella C. V. Moraes Anielle Pina-Costa Ana Maria B. Filippis Patrícia Brasil Guilherme A. Calvet 《Viruses》2022,14(9)
Background: Chikungunya is a viral disease that is transmitted by mosquitoes. It is characterized by an acute onset of fever and severe arthralgia. Methods: We describe six cases of acute and post-acute chikungunya in which viral RNA was detected in semen. Conclusions: The most prolonged detection period was 56 days after illness onset. We attempted to cultivate positive semen samples, but virus isolation was unsuccessful in all cases. 相似文献
997.
998.
Lívia Sacchetto Brbara Aparecida Chaves Edson Rodrigues Costa Aline Souza de Menezes Medeiros Marcelo Gordo Danielle Bastos Araújo Danielle Bruna Leal Oliveira Ana Paula Betaressi da Silva Andria Francesli Negri Edison Luiz Durigon Kathryn A. Hanley Nikos Vasilakis Marcus Vinícius Guimares de Lacerda Maurício Lacerda Nogueira 《Viruses》2021,13(10)
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the agent of coronavirus disease 2019 (COVID-19), is responsible for the worst pandemic of the 21st century. Like all human coronaviruses, SARS-CoV-2 originated in a wildlife reservoir, most likely from bats. As SARS-CoV-2 has spread across the globe in humans, it has spilled over to infect a variety of non-human animal species in domestic, farm, and zoo settings. Additionally, a broad range of species, including one neotropical monkey, have proven to be susceptible to experimental infection with SARS-CoV-2. Together, these findings raise the specter of establishment of novel enzootic cycles of SARS-CoV-2. To assess the potential exposure of free-living non-human primates to SARS-CoV-2, we sampled 60 neotropical monkeys living in proximity to Manaus and São José do Rio Preto, two hotspots for COVID-19 in Brazil. Our molecular and serological tests detected no evidence of SAR-CoV-2 infection among these populations. While this result is reassuring, sustained surveillance efforts of wildlife living in close association with human populations is warranted, given the stochastic nature of spillover events and the enormous implications of SARS-CoV-2 spillover for human health. 相似文献
999.
Selection of highly transfectable variant from mouse mastocytoma P815 总被引:14,自引:0,他引:14
A tk– cell line derived from mouse mastocytoma P815 was transfected with a plasmid carrying a thymidine kinase gene. The tk+ cells were obtained at a frequency of 10–6. From some of these tk+ transfectants it was possible to select tk– cells with BrdU so that these cells could be submitted again to transfection with the thymidine kinase gene. By repeating cycles of transfection and tk+ selection followed by reverse selection with BrdU, it was possible to obtain a stable variant having a 100-fold increase in transfection efficiency. This HTR (high transfection) variant shows a high efficiency of transfection (10–4) for the neomycin-resistance gene as well as for the thymidine kinase gene. 相似文献
1000.
F Robinson S Chen B L Petrig J E Grunwald C E Riva 《Investigative ophthalmology & visual science》1992,33(1):18-22
The acute effect of topical epinephrine HCl 2% on macular capillary blood flow was studied in 18 healthy human volunteers using the blue-field simulation technique. This technique provides a method for quantifying the velocity of leukocytes flowing in macular capillaries. Subjects adjusted the velocity of simulated leukocytes on a computer screen to match that of their own entoptically perceived leukocytes before instilling the drug and 2 hr thereafter. An artificial tear solution was instilled into the fellow eye for a control. Epinephrine instillation resulted in a 8% increase in macular leukocyte velocity and presumably blood flow (P less than 0.03, paired student t-test). 相似文献