全文获取类型
收费全文 | 1337458篇 |
免费 | 114764篇 |
国内免费 | 6377篇 |
专业分类
耳鼻咽喉 | 16717篇 |
儿科学 | 43014篇 |
妇产科学 | 36638篇 |
基础医学 | 183734篇 |
口腔科学 | 36295篇 |
临床医学 | 120753篇 |
内科学 | 278785篇 |
皮肤病学 | 31906篇 |
神经病学 | 110588篇 |
特种医学 | 55569篇 |
外国民族医学 | 274篇 |
外科学 | 210591篇 |
综合类 | 31532篇 |
现状与发展 | 2篇 |
一般理论 | 414篇 |
预防医学 | 106649篇 |
眼科学 | 28118篇 |
药学 | 93825篇 |
5篇 | |
中国医学 | 2230篇 |
肿瘤学 | 70960篇 |
出版年
2018年 | 13434篇 |
2017年 | 10666篇 |
2016年 | 12840篇 |
2015年 | 14350篇 |
2014年 | 20018篇 |
2013年 | 29826篇 |
2012年 | 36371篇 |
2011年 | 39005篇 |
2010年 | 24437篇 |
2009年 | 23959篇 |
2008年 | 36483篇 |
2007年 | 38862篇 |
2006年 | 39996篇 |
2005年 | 38585篇 |
2004年 | 36784篇 |
2003年 | 35885篇 |
2002年 | 33877篇 |
2001年 | 66055篇 |
2000年 | 67924篇 |
1999年 | 56593篇 |
1998年 | 16732篇 |
1997年 | 15021篇 |
1996年 | 16019篇 |
1995年 | 16234篇 |
1994年 | 15106篇 |
1993年 | 14154篇 |
1992年 | 47100篇 |
1991年 | 45748篇 |
1990年 | 43970篇 |
1989年 | 41816篇 |
1988年 | 38758篇 |
1987年 | 38082篇 |
1986年 | 35860篇 |
1985年 | 34635篇 |
1984年 | 26358篇 |
1983年 | 22109篇 |
1982年 | 13848篇 |
1981年 | 12448篇 |
1980年 | 11720篇 |
1979年 | 23545篇 |
1978年 | 17073篇 |
1977年 | 14386篇 |
1976年 | 13183篇 |
1975年 | 13722篇 |
1974年 | 16093篇 |
1973年 | 15396篇 |
1972年 | 14174篇 |
1971年 | 13036篇 |
1970年 | 11880篇 |
1969年 | 11101篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
151.
Rahul S. Loungani Marat Fudim Dave Ranney Ajar Kochar Marc D. Samsky Desiree Bonadonna Akinobu Itoh Hiroo Takayama Koji Takeda Daniel Wojdyla Adam D. DeVore Mani Daneshmand 《Journal of cardiac failure》2021,27(3):327-337
BackgroundVenoarterial extracorporeal membrane oxygenation (VA-ECMO) is increasingly used as a life-saving therapy for patients with cardiovascular collapse, but identifying patients unlikely to benefit remains a challenge.Methods and ResultsWe created the RESCUE registry, a retrospective, observational registry of adult patients treated with VA-ECMO between January 2007 and June 2017 at 3 high-volume centers (Columbia University, Duke University, and Washington University) to describe short-term patient outcomes. In 723 patients treated with VA-ECMO, the most common indications for deployment were postcardiotomy shock (31%), cardiomyopathy (including acute heart failure) (26%), and myocardial infarction (17%). Patients frequently suffered in-hospital complications, including acute renal dysfunction (45%), major bleeding (41%), and infection (33%). Only 40% of patients (n = 290) survived to discharge, with a minority receiving durable cardiac support (left ventricular assist device [n = 48] or heart transplantation [n = 7]). Multivariable regression analysis identified risk factors for mortality on ECMO as older age (odds ratio [OR], 1.26; 95% confidence interval [CI], 1.12–1.42) and female sex (OR, 1.44; 95% CI, 1.02–2.02) and risk factors for mortality after decannulation as higher body mass index (OR 1.17; 95% CI, 1.01-1.35) and major bleeding while on ECMO support (OR, 1.92; 95% CI, 1.23–2.99).ConclusionsDespite contemporary care at high-volume centers, patients treated with VA-ECMO continue to have significant in-hospital morbidity and mortality. The optimization of outcomes will require refinements in patient selection and improvement of care delivery. 相似文献
152.
More than just crushing: a prospective pre‐post intervention study to reduce drug preparation errors in patients with feeding tubes
下载免费PDF全文
![点击此处可从《Journal of clinical pharmacy and therapeutics》网站下载免费的PDF全文](/ch/ext_images/free.gif)
153.
154.
Clinical Spectrum of Capillary Malformation–Arteriovenous Malformation Syndrome Presenting to a Pediatric Dermatology Practice: A Retrospective Study
下载免费PDF全文
![点击此处可从《Pediatric dermatology》网站下载免费的PDF全文](/ch/ext_images/free.gif)
Nicole A. Weitz M.D. Christine T. Lauren M.D. Gerald G. Behr M.D. June K. Wu M.D. Jessica J. Kandel M.D. Philip M. Meyers M.D. Sally Sultan M.D. Kwame Anyane‐Yeboa M.D. Kimberly D. Morel M.D. Maria C. Garzon M.D. 《Pediatric dermatology》2015,32(1):76-84
Capillary malformation–arteriovenous malformation syndrome (CM‐AVM) is an autosomal dominant disorder caused by RASA1 mutations. The prevalence and phenotypic spectrum are unknown. Evaluation of patients with multiple CMs is challenging because associated AVMs can be life threatening. The objective of this study was to describe the clinical characteristics of children presenting with features of CM‐AVM to an academic pediatric dermatology practice. After institutional review board approval was received, a retrospective chart review was performed of patients presenting between 2009 and 2012 with features of CM‐AVM. We report nine cases. Presenting symptoms ranged from extensive vascular stains and cardiac failure to CMs noted incidentally during routine skin examination. All demonstrated multiple CMs, two had Parkes Weber syndrome, and two had multiple infantile hemangiomas. Seven patients had family histories of multiple CMs; three had family histories of large, atypical CMs. Six had personal or family histories of AVMs. Genetic evaluation was recommended for all and was pursued by six families; four RASA1 mutations were identified, including one de novo. Consultations with neurology, cardiology, and orthopedics were recommended. Most patients (89%) have not required treatment to date. CM‐AVM is an underrecognized condition with a wide clinical spectrum that often presents in childhood. Further evaluation may be indicated in patients with multiple CMs. This study is limited by its small and retrospective nature. 相似文献
155.
156.
157.
158.
159.
160.
L. Misery E. Weisshaar E. Brenaut A.W.M. Evers F. Huet S. Ständer A. Reich E. Berardesca E. Serra-Baldrich J. Wallengren D. Linder J.W. Fluhr J.C. Szepietowski H. Maibach for the Special Interest Group on sensitive skin of the International Forum for the Study of Itch 《Journal of the European Academy of Dermatology and Venereology》2020,34(2):222-229
The special interest group on sensitive skin of the International Forum for the Study of Itch previously defined sensitive skin as a syndrome defined by the occurrence of unpleasant sensations (stinging, burning, pain, pruritus and tingling sensations) in response to stimuli that normally should not provoke such sensations. This additional paper focuses on the pathophysiology and the management of sensitive skin. Sensitive skin is not an immunological disorder but is related to alterations of the skin nervous system. Skin barrier abnormalities are frequently associated, but there is no cause and direct relationship. Further studies are needed to better understand the pathophysiology of sensitive skin – as well as the inducing factors. Avoidance of possible triggering factors and the use of well-tolerated cosmetics, especially those containing inhibitors of unpleasant sensations, might be suggested for patients with sensitive skin. The role of psychosocial factors, such as stress or negative expectations, might be relevant for subgroups of patients. To date, there is no clinical trial supporting the use of topical or systemic drugs in sensitive skin. The published data are not sufficient to reach a consensus on sensitive skin management. In general, patients with sensitive skin require a personalized approach, taking into account various biomedical, neural and psychosocial factors affecting sensitive skin. 相似文献