全文获取类型
收费全文 | 1860838篇 |
免费 | 152327篇 |
国内免费 | 6002篇 |
专业分类
耳鼻咽喉 | 26487篇 |
儿科学 | 61297篇 |
妇产科学 | 49027篇 |
基础医学 | 247871篇 |
口腔科学 | 50731篇 |
临床医学 | 178722篇 |
内科学 | 380755篇 |
皮肤病学 | 46017篇 |
神经病学 | 147606篇 |
特种医学 | 70619篇 |
外国民族医学 | 242篇 |
外科学 | 297915篇 |
综合类 | 39754篇 |
现状与发展 | 75篇 |
一般理论 | 610篇 |
预防医学 | 133390篇 |
眼科学 | 44039篇 |
药学 | 126800篇 |
7篇 | |
中国医学 | 4514篇 |
肿瘤学 | 112689篇 |
出版年
2021年 | 15815篇 |
2020年 | 13494篇 |
2019年 | 15811篇 |
2018年 | 26957篇 |
2017年 | 22125篇 |
2016年 | 24401篇 |
2015年 | 26826篇 |
2014年 | 40594篇 |
2013年 | 52966篇 |
2012年 | 59569篇 |
2011年 | 62476篇 |
2010年 | 43179篇 |
2009年 | 44419篇 |
2008年 | 58724篇 |
2007年 | 60562篇 |
2006年 | 63228篇 |
2005年 | 58144篇 |
2004年 | 55603篇 |
2003年 | 51944篇 |
2002年 | 50290篇 |
2001年 | 95436篇 |
2000年 | 96500篇 |
1999年 | 80130篇 |
1998年 | 23480篇 |
1997年 | 20673篇 |
1996年 | 20656篇 |
1995年 | 19808篇 |
1994年 | 17189篇 |
1993年 | 15688篇 |
1992年 | 58781篇 |
1991年 | 56672篇 |
1990年 | 54071篇 |
1989年 | 51972篇 |
1988年 | 47206篇 |
1987年 | 45818篇 |
1986年 | 43187篇 |
1985年 | 40783篇 |
1984年 | 30094篇 |
1983年 | 25582篇 |
1982年 | 14611篇 |
1979年 | 25938篇 |
1978年 | 18015篇 |
1977年 | 15380篇 |
1976年 | 14203篇 |
1975年 | 14910篇 |
1974年 | 17951篇 |
1973年 | 17251篇 |
1972年 | 16034篇 |
1971年 | 14702篇 |
1970年 | 13707篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
11.
12.
Karl Johnson Katherine W. Saylor Isabella Guynn Karen Hicklin Jonathan S. Berg Kristen Hassmiller Lich 《Genetics in medicine》2022,24(2):262-288
PurposeUnderstanding the value of genetic screening and testing for monogenic disorders requires high-quality, methodologically robust economic evaluations. This systematic review sought to assess the methodological quality among such studies and examined opportunities for improvement.MethodsWe searched PubMed, Cochrane, Embase, and Web of Science for economic evaluations of genetic screening/testing (2013-2019). Methodological rigor and adherence to best practices were systematically assessed using the British Medical Journal checklist.ResultsAcross the 47 identified studies, there were substantial variations in modeling approaches, reporting detail, and sophistication. Models ranged from simple decision trees to individual-level microsimulations that compared between 2 and >20 alternative interventions. Many studies failed to report sufficient detail to enable replication or did not justify modeling assumptions, especially for costing methods and utility values. Meta-analyses, systematic reviews, or calibration were rarely used to derive parameter estimates. Nearly all studies conducted some sensitivity analysis, and more sophisticated studies implemented probabilistic sensitivity/uncertainty analysis, threshold analysis, and value of information analysis.ConclusionWe describe a heterogeneous body of work and present recommendations and exemplar studies across the methodological domains of (1) perspective, scope, and parameter selection; (2) use of uncertainty/sensitivity analyses; and (3) reporting transparency for improvement in the economic evaluation of genetic screening/testing. 相似文献
13.
14.
15.
16.
Anela Stanic Denis Rybin Francis Cannata Carole Hohl Jennifer Brody Jessie Gaeta 《AIDS care》2021,33(1):1-9
ABSTRACT The lack of stable housing can impair access and continuity of care for patients living with human immunodeficiency virus (HIV). This study investigated the relationship between housing status assessed at multiple time points and several core HIV-related outcomes within the same group of HIV patients experiencing homelessness. Patients with consistently stable housing (CSH) during the year were compared to patients who lacked CSH (non-CSH group). The study outcomes included HIV viral load (VL), CD4 counts, and health care utilization. Multivariable and propensity weighted analyses were used to assess outcomes adjusting for potential group differences. Of 208 patients, 88 (42%) had CSH and 120 (58%) were non-CSH. Patients with CSH had significantly higher proportion of VL suppression and higher mean CD4 counts. The frequency of nurse visits in the CSH group was less than a half of that in the non-CSH group. Patients with CSH were less likely to be admitted to the medical respite facility, and if admitted, their length of stay was about a half of that for the non-CSH group. Our study findings show that patients with CSH had significantly better HIV virologic control and immune status as well as improved health care utilization. 相似文献
17.
Kara S. Tanaka MD Veronica R. Andaya BA Steven W. Thorpe MD Kenneth R. Gundle MD James B. Hayden MD Yee-Cheen Duong MD Raffi S. Avedian MD David G. Mohler MD Lee J. Morse MD Melissa N. Zimel MD Richard J. O'Donnell MD Andrew Fang MD Robert Lor Randall MD Tina H. Tran BS Christin New BA Rosanna L. Wustrack MD other members of Study Group FORCE 《Journal of surgical oncology》2023,127(1):148-158
18.
19.
20.
Comprehensive evidence regarding the treatment of non-anaemic iron deficiency in patients undergoing valvular heart surgery is lacking. This study aimed to investigate the association between non-anaemic iron deficiency and postoperative outcomes in these patients. We retrospectively analysed 321 patients of which 180 (56%) had iron deficiency (defined as serum ferritin < 100 ng.ml-1 or < 300 ng.ml-1 with transferrin saturation < 20%). While the iron-deficient group had lower pre-operative haemoglobin levels than the non-iron deficient group (median (IQR [range]) 134 (127–141 [120–172]) g.l-1, 143 (133–150 [120–179]) g.l-1, p = 0.001), there was no between-group difference in allogeneic red blood cell transfusion. Median (IQR [range]) days alive and out of hospital at postoperative day 90 was 1 day shorter in the iron-deficient group (80 (77–82 [9–85]) days vs. 81 (79–83 [0–85]) days, p = 0.026). In multivariable analysis, only cardiopulmonary bypass duration (p = 0.032) and intra-operative allogeneic red blood cell transfusion (p = 0.011) were significantly associated with reduced days alive and out of hospital at postoperative day 90. Iron deficiency did not exert any adverse influence on secondary outcomes except length of hospital stay. Our findings indicate that non-anaemic iron deficiency alone is not associated with adverse effects in patients undergoing valvular heart surgery when it does not translate into an increased risk of allogeneic transfusion. 相似文献