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81.
Akio Hiraki Hiroshi Ueoka Toshihiko Matsuo Tomio Nakagawa Tadashi Yoshino Katsuyuki Kiura Masahiro Tabata Katsuyoshi Sakae Yuji Ohtsuki Yoshio Hiraki Mine Harada 《International journal of clinical oncology / Japan Society of Clinical Oncology》1998,3(3):186-190
A 72-year-old Japanese woman, suffering from squamous cell lung cancer with brain metastasis, underwent 2 courses of combination
chemotherapy, consisting of cisplatin and vindesine. Although both the primary tumor and the brain metastasis regressed markedly,
she developed left ocular pain with blurred vision. An abnormal mass was found in the left iris, and cytologic examination
of the aqueous aspirate revealed a few malignant cells, which, when examined by electron microscopy, were considered to be
derived from squamous cell carcinoma of the lung. 相似文献
82.
目的 探讨正常双胎妊娠期间胎儿大脑中动脉搏动指数的变化;并与正常单胎进行比较.方法 采用彩色多普勒超声对34例正常双胎及176例正常单胎胎儿从孕23周至孕35周进行大脑中动脉搏动指数测定.结果 正常双胎胎儿大脑中动脉搏动指数随孕周呈逐渐下降趋势,与正常单胎胎儿比较,孕29周前该值为低,以后较之略高.结论 孕29周后双胎胎儿大脑中动脉血流阻力比单胎其值为高. 相似文献
83.
Guidelines for treatment of ulcerative colitis in children 总被引:2,自引:0,他引:2
Takeshi Tomomasa Akio Kobayashi Kousuke Ushijima Keiichi Uchida Seiichi Kagimoto Toshiaki Shimizu Hitoshi Tajiri Takuhiro Tahara Atushi Yoden for the Working Group of the Japanese Society for Pediatric Gastroenterology Hepatology Nutrition 《Pediatrics international》2004,46(4):494-496
This paper introduces the guidelines for treatment of ulcerative colitis in children, created by the working group of the Japanese Society for Pediatric Gastroenterology, Hepatology and Nutrition (Chair: Yuichiro Yamashiro) and the Japanese Society for Pediatric Inflammatory Bowel Disease (IBD) (Chair: Akio Kobayashi). The ideas of the working group, with regard to the fundamental differences in medical treatment between children and adults, included: (1) for children, intensive medical treatment including appropriate systemic management is important during the acute phase of illness. (2) Treatment with steroids, which can cause growth disturbances, should not be continued for long periods of time. (3) Pulsed steroid therapy, selective removal of blood cells, and intravenous infusion of cyclosporin should be included in the therapeutic option for severe and fluminant cases. 相似文献
84.
Takahiro Matsui Akio Iwasa Masafumi Mimura Seiji Taniguchi Takao Sudo Yutaka Uchida Junichi Kikuta Hidetomo Morizono Rie Horii Yuichi Motoyama Eiichi Morii Shinji Ohno Yasujiro Kiyota Masaru Ishii 《Cancer science》2022,113(8):2916
Histopathological diagnosis is the ultimate method of attaining the final diagnosis; however, the observation range is limited to the two‐dimensional plane, and it requires thin slicing of the tissue, which limits diagnostic information. To seek solutions for these problems, we proposed a novel imaging‐based histopathological examination. We used the multiphoton excitation microscopy (MPM) technique to establish a method for visualizing unfixed/unstained human breast tissues. Under near‐infrared ray excitation, fresh human breast tissues emitted fluorescent signals with three major peaks, which enabled visualizing the breast tissue morphology without any fixation or dye staining. Our study using human breast tissue samples from 32 patients indicated that experienced pathologists can estimate normal or cancerous lesions using only these MPM images with a kappa coefficient of 1.0. Moreover, we developed an image classification algorithm with artificial intelligence that enabled us to automatically define cancer cells in small areas with a high sensitivity of ≥0.942. Taken together, label‐free MPM imaging is a promising method for the real‐time automatic diagnosis of breast cancer. 相似文献
85.
Morimatsu Y Matsubara S Hirose N Ohkuchi A Izumi A Ozaki K Ozawa K Suzuki M 《Archives of gynecology and obstetrics》2008,277(3):267-270
Background Disseminated intravascular coagulation (DIC) caused by placental abruption usually improves rapidly after prompt delivery
and adequate anti-DIC treatment.
Case A 30-year-old nulliparous woman suffered from placental abruption at the 25th week of pregnancy, and emergent cesarean section
was done immediately. She exhibited DIC, which continued even after termination of the pregnancy and anti-DIC treatment. She
also showed neutropenia. We closely observed her, and at the 58th day postpartum, blast cells appeared in the peripheral blood
and she was diagnosed with acute promyelocytic leukemia (APL). Induction chemotherapy was done successfully. The close observation
after delivery enabled us to make the prompt diagnosis/treatment, leading to the complete remission.
Conclusion APL should be added to the list of differential diagnosis when DIC persists even after prompt delivery and appropriate anti-DIC
treatment after placental abruption. 相似文献
86.
Matsubara S Izumi A Nagai T Kikkawa I Suzuki M 《Archives of gynecology and obstetrics》2008,278(2):195-197
BACKGROUND: While vaginal breech delivery, although rare, can cause femur fracture, abdominal breech delivery is not expected to cause it. CASE: A 2,490-g female infant was delivered at term by elective cesarean section for breech presentation. She sustained a fracture of the femur shaft. A simple splinting led to a complete healing of the fracture without sequelae. CONCLUSION: Although abdominal breech delivery reduces the risk of birth trauma, we must be aware that femur fracture can occur regardless of the mode of delivery. 相似文献
87.
Dr. Akio Satoh 《Journal of cancer research and clinical oncology》1932,35(1):574-584
Ohne ZusammenfassungMit 5 Textabbildungen. 相似文献
88.
Matsubara A Tamura A Matsumura S Yokoya H Maruyama S Kobayashi K Kawamoto Y Teishima J Seki M Usui T 《Hiroshima journal of medical sciences》2006,55(4):117-120
A 75-year-old man with a large pituitary adenoma presented with general muscular weakness, including difficulty in rising in the morning and forceless defecation and urination, and muscular pain, numbness and atrophy in the shoulder, neck and thigh. Testosterone replacement and subsequent resection of the pituitary tumor resulted in resolution of the symptoms. The value of pituitary imaging tests for men with hypogonadotropic hypogonadism is discussed. 相似文献
89.
Subdural hematoma in infants can be caused by abuse, and is thought to be more likely if subdural hematoma is associated with retinal hemorrhage and cerebral edema. In Japan, few doctors disagree that cases of subdural hematoma with retinal hemorrhage and cerebral edema with multiple findings on the body are more likely to have been caused by abuse rather than by household accident. On the other hand, in cases where there are no other significant physical findings, only subdural hematoma and retinal hemorrhage, there is a difference of opinion as to whether the injury was caused by an accident or abuse. The reason for this is that neurosurgeons in Japan promoted the concept that infants can develop subdural hematomas and retinal hemorrages due to minor trauma at home before the concept of abusive head trauma became known. In addition, the age distribution of subdural hematomas in Japan differs from that in other countries, with peaks at around 8 months, and the reason for this remains unclear. Therefore, the etiology of infant subdural hematoma in Japan needs to be investigated in greater detail. 相似文献
90.
Matsubara A Mutaguchi K Yasumoto H Takeshima Y Teishima J Seki M Hasegawa Y Usui T 《Hiroshima journal of medical sciences》2006,55(2):65-70
To determine the utility of transrectal ultrasound (TRUS)-guided 10-core prostate biopsy (sextant plus 4 far lateral cores) for Japanese patients, we compared it with the standard sextant for detection of prostate cancer. The study patients were 564 consecutive Japanese men (median age 71 years) who underwent 10-core biopsy because of PSA values of > or = 2.0 ng/ml at Hiroshima University Hospital between March 2000 and December 2004. The overall cancer detection rate for the 10-core biopsy was 42.6% (240/564), which was significantly higher than the 36.3% (205/564) for the standard sextant biopsy (P=0.0330), with a 14.6% (35/240) improvement. The 10-core biopsy also detected a significant number of additional cancers in the sub-groups of patients with PSA values of 2 to approximately 10 ng/ml (P=0.0275), a prostate volume of > 20 cc (P=0.0440), or normal findings of digital rectal examination (P=0.0304). The 10-core biopsy scheme detected 9.6% and 2.1 to approximately 8.3% more cancers than the lateral sextant (apex, lateral mid portion, and lateral base) and the probable different combinations of 8-core biopsy designs, respectively. Compared to the standard sextant biopsy, the 10-core biopsy did not detect an increased proportion of clinically insignificant cancers. There was no severe morbidity, and only 2 patients (0.4%) were briefly hospitalized due to high fever. These results show that the TRUS-guided 10-core biopsy yields a better prostate cancer detection rate than the 6-core or 8-core protocol without severe complications. Therefore, it seems to be practicable for Japanese patients. 相似文献