全文获取类型
收费全文 | 475篇 |
免费 | 28篇 |
国内免费 | 4篇 |
专业分类
耳鼻咽喉 | 6篇 |
儿科学 | 26篇 |
妇产科学 | 2篇 |
基础医学 | 53篇 |
口腔科学 | 6篇 |
临床医学 | 55篇 |
内科学 | 197篇 |
皮肤病学 | 4篇 |
神经病学 | 14篇 |
特种医学 | 9篇 |
外国民族医学 | 1篇 |
外科学 | 61篇 |
综合类 | 5篇 |
预防医学 | 25篇 |
眼科学 | 4篇 |
药学 | 22篇 |
肿瘤学 | 17篇 |
出版年
2023年 | 4篇 |
2022年 | 6篇 |
2021年 | 29篇 |
2020年 | 17篇 |
2019年 | 29篇 |
2018年 | 23篇 |
2017年 | 10篇 |
2016年 | 23篇 |
2015年 | 18篇 |
2014年 | 22篇 |
2013年 | 17篇 |
2012年 | 33篇 |
2011年 | 37篇 |
2010年 | 19篇 |
2009年 | 16篇 |
2008年 | 19篇 |
2007年 | 26篇 |
2006年 | 24篇 |
2005年 | 11篇 |
2004年 | 28篇 |
2003年 | 21篇 |
2002年 | 11篇 |
2001年 | 9篇 |
2000年 | 10篇 |
1999年 | 10篇 |
1998年 | 3篇 |
1997年 | 5篇 |
1996年 | 6篇 |
1995年 | 2篇 |
1994年 | 3篇 |
1993年 | 3篇 |
1992年 | 2篇 |
1991年 | 3篇 |
1986年 | 1篇 |
1985年 | 2篇 |
1980年 | 1篇 |
1959年 | 1篇 |
1958年 | 3篇 |
排序方式: 共有507条查询结果,搜索用时 15 毫秒
121.
Congenital labyrinthine dysplasia with a translabyrinthine cerebrospinal fluid (CSF) fistula may be an anatomic cause for recurrent meningitis. This condition is usually seen in children aged 5 to 10 years who present with sensorineural hearing loss (SNHL) and CSF discharge through the nose or ear, with or without recurrent meningitis. Multidetector-row computed tomography (MDCT) and high-resolution T2-weighted magnetic resonance imaging (MRI) of the petrous portion of the temporal bone can help to diagnose this abnormality. We report a case of translabyrinthine CSF fistula in an adult-a 30-year-old man-who presented with recurrent pneumococcal meningitis, a long history of a clear nasal discharge, and evidence of SNHL. MDCT and MRI of the temporal bone demonstrated a cystic-appearing cochleovestibular malformation (an incomplete partition type I) in the right inner ear. Imaging also showed an absence of the basal turn of the cochlea and the cribriform membrane at the lateral end of the right internal auditory canal, which was shorter and narrower than normal. Evidence of fluid in the right middle ear suggested a CSF fistula. 相似文献
122.
Brittany B Dennis Leen Naji Yasmin Jajarmi Aijaz Ahmed Donghee Kim 《World journal of gastroenterology : WJG》2021,27(29):4818-4830
Hepatitis C virus (HCV) is a global health concern associated with significant morbidity and mortality. Before the approval of second-generation direct-acting antiviral agents (DAAs), interferon therapy and liver transplantation constituted the mainstay of treatment. The introduction of well-tolerated oral DAAs in late 2013 has revolutionized HCV management with over 95% cure rates. The pre dominance of HCV-related liver transplantations has declined following the widespread approval of DAAs. Despite the unparallel efficacy observed among these novel therapies, pharmaceutical costs continue to limit equitable access to healthcare and likely contribute to the differential HCV infection rates observed globally. To reduce the burden of disease worldwide, essential agenda items for all countries must include the prioritization of integrated care models and access to DAAs therapies. Through transparent negotiations with the pharmaceutical industry, the consideration for compassionate release of medications to promote equitable division of care is paramount. Here we provide a literature review of HCV, changes in epidemiologic trends, access issues for current therapies, and global inequities in disease burden. 相似文献
123.
Aijaz Ahmad Hakeem Feroze Shaheen Hakim Shafi Tariq A. Gojwari Shubana Rasool 《Journal of gastrointestinal surgery》2009,13(3):576-577
Obturator hernia is rare, constituting <2% of all abdominal hernias. Clinical diagnosis is rarely made due to vague signs
and symptoms. Delayed diagnosis markedly increases postoperative morbidity and mortality especially because the affected patients
are often old with other comorbid conditions. Pelvic CT is almost 100% accurate in the diagnosis of obturator hernia and should
be the modality of choice in older patients presenting with intestinal obstruction of unknown etiology. 相似文献
124.
BACKGROUND AND PURPOSE: Although the orexin system has an established role in narcolepsy, the mechanism of orexin deficiency in human cases is unknown. The strong association with human leukocyte antigen (HLA) DQB1*0602 suggests an autoimmune basis, but supporting evidence is lacking. Although data indicate that HLA status is not the sole genetic factor, only a single case of a functional orexin system mutation has been discovered, in a study with a selection bias designed to increase yield. In this study, we examined the prepro-orexin gene for mutations in a cohort of unrelated patients with narcolepsy from a national UK referral centre. PATIENTS AND METHODS: Subjects with a diagnosis of narcolepsy were recruited from a patient database. DNA samples were obtained using buccal smear kits. The prepro-orexin gene was amplified using polymerase chain reactions and screened for polymorphisms and mutations. RESULTS: Eighty-one patients were recruited, of whom 69 provided DNA samples. A previously described intronic single nucleotide polymorphism, of unlikely significance, was identified in one subject who had typical clinical and electrophysiological features of narcolepsy. It was located 16 base pairs downstream from exon 1. No other mutations were found. CONCLUSION: This result supports existing evidence which indicates that mutations of the prepro-orexin gene are rare and that the genetic contribution to the aetiology of human narcolepsy is likely to be complex. 相似文献
125.
126.
127.
128.
G. R. Sadler L. Oberle-Edwards A. Farooqi W. M. Hryniuk 《Supportive care in cancer》2000,8(3):209-214
The object of this work was to conduct a rapid assessment of a teaching hospital's promotion of optimal oral health among
its chemotherapy patients. A pilot study was undertaken, which included focus interviews with oncology clinic staff, a review
of the fellowship training curriculum, and unobtrusive observations in the clinic setting. Charts were also audited for oncology
patients who were probable chemotherapy candidates. A review of the data offered no evidence that oral health care was routinely
addressed in a preventive context prior to the initiation of chemotherapy. Promotion of oral health care will help reduce
the risk of oral sequelae of chemotherapy for patients and the subsequent impact of the oral sequelae on patients' chemotherapeutic
regimen, thereby improving patients' chances of survival and improving their quality of life. Other teaching hospitals may
wish to conduct a similar rapid assessment to determine whether they too could improve patient care and professional education
in this area by incorporating pre-chemotherapy oral health evaluation and treatment into routine care for cancer patients.
Published online: 18 November 1999 相似文献
129.
130.