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排序方式: 共有195条查询结果,搜索用时 15 毫秒
81.
82.
Thirty-five patients with 67 measureable cutaneous or lymph node metastases from malignant melanoma were treated with radiation therapy in a variety of total doses and dose fractions. There was no correlation between total dose and response rate. However, there was a strong correlation between fraction size and response rate. There were four (9%) complete responses in 43 lesions treated with fractions less than or equal to 500 rad (5 Gy) compared with 12 (50%) complete responses in 24 lesions treated with fractions greater than 500 rad (5 Gy) (P = .0006). Initial response rate was found to correlate strongly with local control at 1 year. The results were then analyzed with respect to lesion size, cutaneous versus nodal lesions, and site of cutaneous lesion (trunk, head and neck, or extremity). Correlation between fraction size and response rate was independent of lesion size, although there were fewer complete responses with increasing lesion size. Correlation was not seen in nodal lesions but was particularly striking in cutaneous lesions. This correlation was statistically significant only for cutaneous lesions of the extremities. 相似文献
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Anne MV Brooks MD PhD FRACO FRACS FRACP WE Gillies FRACO FRACS FRCS 《Clinical & experimental ophthalmology》1992,20(3):235-238
The effect of cataract surgery in patients with glaucoma controlled by either topical medication or surgery was assessed in 64 patients. At one year there was a small significant fall in intraocular pressure (IOP) for eyes without previous surgery (preoperative IOP 18.9 ±4.7, range 12 to 35 mmHg; postoperative IOP 16.3 ±3.4, range 10 to 26 mmHg; P<0.01) and also for those with previous surgery (preoperative IOP 15.0 ±4.3, range 3 to 22 mmHg; postoperative IOP 14.2 ±3.7, range 6 to 22 mmHg, P<0.05). There was a significantly greater incidence of high rise in IOP to 30 mmHg or more immediately after operation in patients without (32%) than those with previous surgery (13%) ( x 2 = 3.9; P<0.05). Complications were minimal in each group. lridotomy to deliver the nucleus was necessary in nine eyes without and 21 with previous surgery. Cataract extraction usually causes only a small fall in IOP in glaucomatous patients. If a separate corneal section is used there is no loss of function of the filtering bleb in patients with previous glaucoma surgery. 相似文献
85.
原发性脾囊肿是一种罕见的疾病,目前尚缺乏对该疾病的理想治疗方法的相关研究.大多数原发性脾囊肿是上皮性囊肿.近几年,腹腔镜脾脏外科手术普及率不断提高.该研究报告了关于经腹腔镜保脾手术治疗脾囊肿的相关经验.1996年至2006年间,作者治疗了11例有症状的非寄生虫性脾脏巨大囊肿病人.病人均诉左上腹涨满症状,触诊可扪及腹部包块.术前腹部超声及CT均已明确诊断.病人接受经腹腔镜脾脏囊肿部分切除术或脾脏囊肿开窗减压术.结果发现,7例病人为脾脏间皮囊肿,2例为脾脏表皮样囊肿,2例为脾脏假性囊肿,没有发现囊肿癌变.手术操作时间为62~85 min,无中转开腹. 相似文献
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Metzinger L; Blake DJ; Squier MV; Anderson LV; Deconinck AE; Nawrotzki R; Hilton-Jones D; Davies KE 《Human molecular genetics》1997,6(7):1185-1191
Mutations in the genes encoding dystrophin or dystrophin-associated
proteins are responsible for Duchenne muscular dystrophy or various forms
of limb-girdle muscular dystrophies respectively. We have recently cloned
the gene for the murine 87 kDa postsynaptic protein dystrobrevin, a
dystrophin-associated protein. Anti-dystrobrevin antibodies stain the
sarcolemma in normal skeletal muscle indicating that dystrobrevin
co-localises with dystrophin and the dystrophin- associated protein
complex. By contrast, dystrobrevin membrane staining is severely reduced in
muscles of Duchenne muscular dystrophy patients, consistent with
dystrobrevin being a dystrophin-associated protein. Interestingly,
dystrobrevin staining at the sarcolemma is dramatically reduced in patients
with limb-girdle muscular dystrophy arising from the loss of one or all of
the sarcoglycan components. Normal dystrobrevin staining is observed in
patients with other forms of limb- girdle muscular dystrophy where
dystrophin and the rest of the dystrophin-associated protein complex are
normally expressed and in other neuromuscular disorders. Our results show
that dystrobrevin- deficiency is a generic feature of dystrophies linked to
dystrophin and the dystrophin-associated proteins. This is the first
indication that a cytoplasmic component of the dystrophin-associated
protein complex may be involved in the pathogenesis of limb-girdle muscular
dystrophy.
相似文献
89.
MV SINGH SK GANGULI BM AIYANNA MV SINGH SK GANGULI BM AIYANNA 《Medical Journal Armed Forces India》1996,52(4):229-232
A study was conducted of the epidemiological aspects of 500 fresh cases of burns during the period February to August 1989. Women in the reproductive age group from the lower socioeconomic strata were the most frequently victims (52.8%). Four hundred and thirteen (82.5%) patients sustained accidental burns, 62 (12.4%) were suicidal and 25 (5%) homicidal. Majority (72%) of the accidents occurred as a consequence of garments catching fire. Though most of the subjects wore cotton garments, mortality was higher among those wearing synthetic fabric. Low socioeconomic conditions, overcrowding in the house, floor-level cooking, unsafe cooking appliances and the prevalent clothing pattern stand out prominently as risk factors for burn injury.KEY WORDS: Burns, Epidemiology, Risk factors 相似文献
90.
The mutations of the p53 gene previously represented one of several genetic changes involved in the development of bovine leukemia virus (BLV)-induced lymphosarcoma, while the effects of these mutations on the function of p53 are unknown. We identified four mutations of p53 gene in BLV-infected cattle with lymphosarcoma and demonstrated clearly the existence of two functionally distinct groups of mutants: (i) the mutant forms with substitutions at codons 241 and 242, which were mapped within an evolutionally conserved region and corresponded to the human "hot-spot" mutations, had completely lost the capacities for transactivation and growth suppression and gained transdominant repression activity in p53-null SAOS-2 cells; and (ii) the mutations at codons 206 and 207 were located outside the evolutionally conserved regions. These mutants partially retained the capacity for transactivation and growth suppression and failed to inhibit the transactivation activity of coexpressed wild-type p53, instead showing an enhancement of this activity. In addition, protein analysis using an antibody specific for the mutant form revealed that the mutations at codons 206 and 242 induced a "mutant" conformation of the bovine p53 proteins. Collectively, these results show that mutations of p53 gene in BLV-infected cattle with lymphosarcoma can potentially alter its physiological function and may play an important role in BLV-induced leukemogenesis. Copyright 1998 Academic Press. 相似文献