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81.
Blessing N. R. Jaja Daniel Attalla R. Loch Macdonald Tom A. Schweizer Michael D. Cusimano Nima Etminan Daniel Hanggi David Hasan S. Claiborne Johnston Peter Le Roux Benjamin Lo Ada Louffat-Olivares Stephan Mayer Andrew Molyneux Adam Noble Audrey Quinn Thomas Schenk Julian Spears Jeffrey Singh Michael Todd James Torner Ming Tseng William van den Bergh Mervyn D. I. Vergouwen George K. C. Wong 《Neurocritical care》2014,21(3):551-559
Researchers and other stakeholders continue to express concern about the failure of randomized clinical trials (RCT) in subarachnoid hemorrhage (SAH) to show efficacy of new treatments. Pooled data may be particularly useful to generate hypotheses about causes of poor outcomes and reasons for failure of RCT in SAH, and strategies to improve them. Investigators conducting SAH research collaborated to share data with the intent to develop a large repository of pooled individual patient data for exploratory analysis and testing of new hypotheses relevant to improved trial design and analysis in SAH. This repository currently contains information on 11,443 SAH patients from 14 clinical databases, of which 9 are datasets of recent RCTs and 5 are datasets of prospective observational studies and hospital registries. Most patients were managed in the last 15 years. Data validation and quality checks have been conducted and are satisfactory. Data is available on demographic, clinical, neuroimaging, and laboratory results and various outcome measures. We have compiled the largest known dataset of patients with SAH. The SAHIT repository may be an important resource for advancing clinical research in SAH and will benefit from contributions of additional datasets. 相似文献
82.
Luis Rogério Cosme Silva Santos Ada ávila Assun??o Eduardo de Paula Lima 《Revista de saúde pública》2014,48(5):750-757
OBJECTIVE
To analyze the factors associated with back pain in adults who live in quilombola territories.METHODS
A population-based survey was performed on quilombola communities of Vitória da Conquista, state of Bahia, Northeastern Brazil. The sample (n = 750) was established via a raffle of residences. Semi-structured interviews were conducted to investigate sociodemographics and employment characteristics, lifestyle, and health conditions. The outcome was analyzed as a dichotomous variable (Poisson regression).RESULTS
The prevalence of back pain was of 39.3%. Age ≥ 30 years and being a smoker were associated with the outcome. The employment status was not related to back pain.CONCLUSIONS
The survey identified a high prevalence of back pain in adults. It is suggested to support the restructuring of the local public service in order to outline programs and access to healthy practices, assistance, diagnosis, and treatment of spine problems. 相似文献83.
Dario Cocito Aristide Merola Erdita Peci Anna Mazzeo Raffaella Fazio Ada Francia Paola Valentino Rocco Liguori Massimiliano Filosto Gabriele Siciliano Angelo Maurizio Clerici Stefania Lelli Girolama Alessandra Marfia Giovanni Antonini Ilaria Cecconi Eduardo Nobile-Orazio Leonardo Lopiano SCIg Chronic Dysimmune Neuropathies Italian Network 《Journal of neurology》2014,261(11):2159-2164
This multi-center Italian prospective observational study reports the 4 months follow-up data of 87 patients affected by chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) and multifocal motor neuropathy (MMN) shifted from intravenous to subcutaneous immunoglobulin treatment. A therapeutic shift from intravenous to subcutaneous immunoglobulin was performed in 87 patients (66 CIDP; 21 MMN) affected by immune-mediated peripheral neuropathies with evidence of a sustained clinical response to intravenous immunoglobulin. Patients were evaluated by means of the Overall Neuropathy Limitation Scale, Medical Research Council Scale and Life Quality Index questionnaire, both at the time of therapeutic shift and after 4 months of subcutaneous immunoglobulin treatment. A sustained clinical efficacy was observed after the switch to subcutaneous immunoglobulin: the Overall Neuropathy Limitation Scale score improved in the group of 66 CIDP patients (P = 0.018), with only one subject reporting a worsening of 1 point, and remained stable in the group of 21 MMN patients (P = 0.841), with one subject reporting a worsening of two points. An improvement in the patient’s perception of therapeutic setting was reported in both groups. This large multi-center study confirms the short-term clinical equivalence of subcutaneous versus intravenous immunoglobulin and a possible improvement in the patient’s perception of therapeutic setting with the subcutaneous administration. However, further studies are required to extend the results to a longer observational period. 相似文献
84.
Maria M. Farias Constanza Gajardo Veronica Alvarez Ada Cuevas Maria L. Perez-Cotapos 《Obesity surgery》2014,24(10):1826-1829
Background
Bariatric procedures have beneficial effects on metabolic disturbances, including dermatological conditions. Short-term skin reactions associated with sleeve gastrectomy are not described in the literature.Methods
We reviewed our database for patients who underwent bariatric surgery between May and October 2013 who reported a cutaneous rash during the short-term post-surgical period.Results
Of a total of 195 patients, 8 (0.02 %) developed acute skin reactions during the first 3 months. Case 1 was compatible with reticulated papillomatosis. Case 2 was diagnosed as recurrent angioedema. Cases 3, 4, and 7 presented a cutaneous drug reaction to vitamin supplementation. Cases 5, 6, and 8 seemed to be secondary to xerosis and responded to lubrication.Conclusion
Acute cutaneous skin reactions after bariatric surgery are unusual. When they do occur, they appear to be benign conditions. 相似文献85.
Ming Yu Yingcai Wang Jiang Zhu MichaelD. Bartberger Jude Canon Ada Chen David Chow John Eksterowicz Brian Fox Jiasheng Fu Michael Gribble Xin Huang Zhihong Li Jiwen Liu Mei-chu Lo Dustin McMinn Jonathan D. Oliner Tao Osgood Yosup Rew AnneY. Saiki Paul Shaffer Xuelei Yan Qiuping Ye Dongyin Yu Xiaoning Zhao Jing Zhou StevenH. Olson Julio C. Medina Daqing Sun 《ACS medicinal chemistry letters》2014,5(8):894-899
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Alicia Colvin Gale A. Richardson Jill M. Cyranowski Ada Youk Joyce T. Bromberger 《Archives of women's mental health》2014,17(4):269-278
This study aims to determine whether family history of depression predicts major depression in midlife women independent of psychosocial and health profiles at midlife. Participants were 303 African American and Caucasian women (42–52 years at baseline) recruited into the Study of Women’s Health Across the Nation (SWAN) and the Women’s Mental Health Study (MHS) in Pittsburgh. Major depression was assessed annually with the Structured Clinical Interview for DSM-IV. Family mental health history was collected at the ninth or tenth follow-up. Multivariable logistic regression was used to determine whether family history of depression predicted major depression in midlife, adjusting for covariates. The odds of experiencing major depression during the study were three times greater for those with a family history than for those without a family history (OR?=?3.22, 95 % CI?=?1.95–5.31). Family history predicted depression (OR?=?2.67, 95 % CI?=?1.50–4.78) after adjusting for lifetime history of depression, age, trait anxiety, chronic medical conditions, and stressful life events. In analyses stratified by lifetime history of depression, family history significantly predicted depression only among women with a lifetime history of depression. Family history of depression predicts major depression in midlife women generally, but particularly in those with a lifetime history of depression prior to midlife. 相似文献
90.
Paediatric critical incident analysis: lessons learnt on analysis,recommendations and implementation
Cynthia van der Starre Monique van Dijk Ada van den Bos Dick Tibboel 《European journal of pediatrics》2014,173(11):1449-1457
The objectives of this study were to identify causal and contributing factors of serious patient safety incidents in a paediatric university hospital, to report on ensuing recommendations and to assess the extent of implementation of the recommendations. The possible causal and contributing factors identified in 17 incidents were classified by a system devised by Vincent et al. Proposed recommendations were classified by the same system, and degrees of implementation were established. A median of 5 causal and contributing factors per incident were identified. Twenty-two percent of all factors were related to teamwork and 22 % to task factors. A median of 5 recommendations per analysis were formulated. Most recommendations were related to task factors (36 %). The time load of each analysis was a mean of 27 h. One third of the recommendations have been acted upon, mostly those related to task and team factors. Conclusion: Incident analysis is time-consuming but yields indispensable information on causal and contributing factors, presenting numerous opportunities for quality improvement. The value of these analyses could be improved by appointing responsibilities and setting up time frames for implementation. A bottom-up approach with managerial support appears to be a key to turning incident analysis and quality improvement into an ongoing process. 相似文献