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141.
ALAN R KRISTAL DrPH RUTH E PATTERSON PhD RD MARIAN L NEUHOUSER PhD RD MARK THORNQUIST PhD DIANNE NEUMARK-SZTAINER PhD RD CHERYL L ROCK PhD RD MARTHA C BERLIN LAWRENCE CHESKIN MD PAMELA J SCHREINER PhD 《Journal of the American Dietetic Association》1998,98(11):1290-1296
Objective To describe the design of the Olestra Postmarketing Surveillance Study (OPMSS) and to present baseline results from the sentinel site. The purpose of the OPMSS is to monitor consumption patterns of olestra-containing snacks and to determine whether consumption affects nutritional status.Design The OPMSS combines repeated cross-section, random-digit dial telephone surveys before and after the market release of olestra-containing foods as well as intensive dietary and clinical assessments on a subsample of survey participants.Subjects Data are from baseline telephone (n=1,962) and clinical (n=1,069) assessment of participants (aged 18 to 74 years) in the Marion County, Indiana, sentinel site. Mean age of participants in the telephone survey was 43.2 years; 19% of respondents were black and 29% had completed college.Statistical analysis Analyses examined associations among savory snack use, fruit and vegetable consumption, and demographic and health-related characteristics. Data from the telephone survey were adjusted to be representative of the Marion County population.Results Almost 96% of the population surveyed had eaten savory snacks in the month before the survey: 74% had eaten regular-fat, 26% fat-reduced, and 78% nonfat types. Total snack consumption did not differ by gender, education, or race. Residents younger than 35 years ate snacks 16 times a month compared with 12 times a month among older residents. Types of snacks consumed differed markedly by demographic characteristics. Male, younger, and less educated residents ate more regular-fat snacks; female, white, and college-educated residents ate more nonfat snacks. In general, residents practicing healthful behaviors, including not smoking, eating fruits and vegetables, and exercising, also ate fewer regular-fat and more nonfat snacks. Fat intake was also related linearly to use of snack foods, ranging from 33.2% of energy among those consuming 1 serving per month or less to 36.8% among those consuming 20 or more servings per month.Applications/conclusions Procedures for recruitment and nutrition assessment appear adequate for evaluating the impact of olestra consumption on nutritional status. Nutritionists should be aware that there is potential for relatively high olestra consumption, given that almost 35% of Marion County residents eat snack foods at least 20 times a month. Consumers eating at least 20 servings of snacks per month derived more than 12% of their total energy and fat from snack foods, which suggests that substituting olestra snacks could substantially reduce intakes of fat and energy. J Am Diet Assoc. 1998;98:1290–1296. 相似文献
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VICTOR PARSONNET ALAN D. BERNSTEIN DONNA NEGLIA ARIF OMAR 《Pacing and clinical electrophysiology : PACE》1994,17(12):2274-2278
This study was undertaken to assess the effects of enclosing permanent pacemaker and ICD pulse generators in a stretch-polyester pouch prior to implantation. Follow-up of 223 patients with oversized pacemakers and with ICDs and 344 witb standard-sized pacemaker pulse generators showed that the pouch was effective in decreasing the frequency of pulse generator migration and extrusion. 相似文献
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RALPH-HEIKO MATTERN YUSUkE AMINO ETTORE BENEDETTI MURRAY GOODMAN 《Chemical biology & drug design》1997,50(4):286-299
Four potent sweet-tasting molecules, N-(3, 3-dimethylbutyl)-l -aspartyl-l -phenylalanine methylester 1 (7000 times more potent than sucrose), N-(3, 3-dimethylbutyl)-l -aspartyl-d -valine (S)-α-ethylbenzylamide 2 (3000 time more potent than sucrose), l -aspartyl-d -valine (R)-α-methoxymethylbenzylamide 3 (1350 times more potent than sucrose and l -aspartyl-(1R, 2S, 4S)-1-methyl-2-hydroxy-4-phenylhexylamide 4 (2500 times more potent than sucrose) were studied by H NMR and computer simulations. These flexible molecules adopt multiple conformations in solution. The “L-shaped” structure, which we believe to be responsible for sweet taste is accessible to all four compounds in solution. Extended conformations with the AH and B-containing moieties in the +y-axis and the hydrophobic group X pointing in the y-axis have also been observed for all four sweeteners. For compounds 1 and 3 , the solid-state conformations were determined by X-ray diffraction studies. These results demonstrate that compounds 1 and 3 adopt an “L-shaped” structure even in the crystalline state. The extraordinary potency of the N-alkylated compound 1 compared with the unsubstituted Asp-Phe-OMe may be explained by the effect of a second hydrophobic binding domain in addition to interactions arising from the “L-shaped” structure. 相似文献
147.
ALAN NELSON M.D. H. DAVID FRANK M.D. HOWARD L. TAUBIN M. D. 《The American journal of gastroenterology》1979,72(3):282-284
A patient with liver abscess in association with regional enteritis is reported. Liver abscess should be suspected in patients with regional enteritis who present with fever, elevated serum alkaline phosphatase, liver tenderness, right upper quadrant pain or hepatomegaly. 相似文献
148.
Circulatory changes in chronic liver disease 总被引:28,自引:0,他引:28
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