瘤型麻风一例

临床资料 患者,男,46 岁. 因"面颊、腰背部及四肢伸侧多发暗红丘疹结节1年余,伴瘙痒"来我科就诊.患者1年前发现面颊、腰背部及四肢伸侧暗红丘疹,伴痒感,外院曾以"湿疹、虫咬皮炎及结节性痒疹"等治疗,疗效欠佳,后皮损缓慢增多,搔抓后结痂,来我科就诊.患者长期居住于湖北省恩施市,无明确麻风接触史.否认肝炎、结核及麻风等...     

分形和分形维数及其在医学形态学领域的应用

自１９６７年美籍法国数学家Ｍａｎｄｅｌｂｒｏｔ在《科学》杂志上发表“英国的海岸线有多长？”的论文［１］，分形（ｆｒａｃｔａｌｓ）的概念已开始萌芽生长，１９７７年他出版了奠基性的《分形：形、机遇与维》和１９８２年出版的《自然界的分形几何学》［２，３］，...     

一毛囊角化病家系ATP2A2基因突变检测

目的:检测一毛囊角化病家系的ATP2A2基因突变。方法:提取2例患者外周血DNA,采用聚合酶链式反应及DNA直接测序方法,检测患者ATP2A2基因突变。结果:该家系患者及其两女儿存在ATP2A2基因的碱基缺失突变,即ATP2A2基因第10个外显子1220位开始缺失了AA 2个碱基。而该家系中其他正常者未发现此突变。结论:ATP2A2基因第10个外显子1220delAA突变可能与该家系患者临床表型有关。     

内皮素对黑素瘤A375细胞转化生长因子-β1及磷酸化Smad 3蛋白表达的调节

Objective To investigate the effects ofendothelin-1 (ET-1) and endothelin-3 (ET-3) on the expression of transformation growth factor-beta 1 (TGF-β1) and phosphorylation of Smad 3 in malignant melanoma cell line, A375. Methods Cultured A375 cells were classified into 5 groups, i.e. control group (no stimulation), ET-1 group (stimulated with ET-1), ET-1+BQ123 group (treated with ET-1 and BQ123),ET-1 + BQ788 group (treated with ET-1 and BQ788), ET-3 group (stimulated with ET-3), to receive different stimulation. The working concentrations were 0, 0.1, 1, 10, 100 nmol/L for ET-1 and ET-3, 10 μmol/L for BQ123 and BQ788. After another 12- and 24-hour culture, ELISA, RT-PCR and Western blot were used to detect the expression of TGF-β1 protein and mRNA as well as phosphorylated Smad 3 (P-Smad 3). Results The expression of TGF-β1 in A375 cells was up-regulated by ET-1, but down-regulated by ET-3, and both of the effects were in a concentration-dependent manner. Under the stimulation with ET-1 and ET-3 of 100 nmol/L, the level of TGF-β1 reached 1289.38 ± 89.42 ng/L per 105 cells and 85.09 ± 9.37 ng/L per 105 cells, respectively, significantly different from that in unstimulated cells (both P < 0.05). BQ123 signifi-cantly blocked the up-regnlatory effect of ET-1 on the expression TGF-β1 protein(P < 0.05), but BQ788 had no significant influence on the effect, so was the case with TGF-β1 mRNA. Western blot revealed that ET-1significantly elevated the expression of P-Smad 3 in A375 cells (P <0.05), and the elevation was significantly inhibited by BQ123, but not by BQ788. The expression of P-Smad 3 was statistically decreased by ET-3 in A375 cells (P <0.05). Conclusions The expression of TGF-β1 could be enhanced by ET-1, but suppressed by ET-3. It is likely that endothelin receptor A mediates the phosphorylation of Smad 3 induced by ET-1.     

Study on the role of interleukin-4 in experimental murine systemic candidiasis

Candida albicans is the most common oppor-tunistic fungal pathogen,and systemic Candidiasis isgetting increasingly dangerous to patients with im-mune dysfunctions[1] . Interleukin- 4(IL- 4) ,mainlysecreted by activated CD 4T cells,can enhance thedifferentiation from Th0 cells to Th2 cell[2 ] ,inhibitthe differentiation from Th0 cells to Th1cells and theability of neurtrophils and macrophages to phagocy-tose or kill Candida albicans[3 ,4 ] . The detection ofthe level of IL- 4secreted by i…     

40例成人和28例儿童麻疹比较分析

对1996年2月～1999年9月我院收治的40例成人麻疹和28例儿童麻疹进行了比较分析,结果如下: 1 临床资料 40例患者中,男21例,女19例,18～20岁9例,～30岁29例,3l岁和34岁各1例。儿童组28     

多发痛风结节1例

临床资料 患者男,55岁.因"双手指、足第一趾跖关节内侧发生黄色结节20年余"就诊.轻压痛,皮疹可自行破溃,溢出豆渣样物,伴全身关节反复疼痛.皮肤科查体:双手指、足第一跖趾关节内侧黄白色或淡黄色结节,绿豆至核桃大,质中到硬,关节活动略受限.     

葡萄球菌性烫伤样皮肤综合征32例临床分析

葡萄球菌性烫伤样皮肤综合征(staphylococcal scalded skin sydrome,SSSS)是由金黄色葡萄球菌产生的表皮剥脱毒素(exfoliative toxin,ET)引起的,好发于婴幼儿的急性皮肤感染性疾病.本病以往相对少见,但随着金黄色葡萄球菌感染率日益增加,对常规抗生素的耐药性也增加,此病的发病率有增高的趋势,即使使用了广谱抗生素,此病也有着较高的死亡率.1因此,提高对该病的认识很有必要.我们对近4年来诊断的32例SSSS患儿进行了总结和分析报道如下.     

Olmsted综合征1例及文献复习

报道1例Olmsted综合征,并对国内外文献进行复习,对42例进行总结和分析其临床特点。本例患儿出生后双手足指趾甲呈淡白色,从出生后100d双手足、肛周发生境界清楚的角化性斑块,进行性加重,双手足损害影响患儿行走和抓物,口周也发生角化性红斑,伴有甲营养不良和头发稀疏。根据皮损的形态特点和分布诊断Olmsted综合征。     

组织工程神经桥接物的研究进展

周围神经（peripheral nerve,PN）缺损的修复一直是临床上一大率题,随着材料科学和分子生物学的发展,用于神经缺损修复研究的桥接物品种越来越多。这些材料虽已被证明有一定的促周围神经再生的作用,但修复效果仍然不满意,尚不能取代自体神经移植。近年来,随着组织工程的兴起,组织工程化神经已成为目前研究的焦点。