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21.
Objective PET with 18F-fluorodeoxyglucose (FDG) has been used to beth detect and stage a variety of malignancies. The aim of this retrospective study was to evaluate the clinical value of 18F-FDG PET/CT for recurrence and metastasis in gastric carcinoma patients after total gastrectomy. Methods A total of 45 gastric carcinoma patients who underwent total gastrectomy were included. PET/CT scans were obtained for restaging. The " gold standard" of 18F-FDG PET/CT diagnostic accuracy was based on either histopathology or clinical follow-up. By using the t-test from SPSS 11.5, the cut-off of maximum standard-ized uptake values (SUVmax) from 18F-FDG to differentiate benign from malignant lesion at stomach were determined and calculated. Results (1) Of the 45 patients, 22 were suspicion recurrent lesion at stomach. Of the 22 patients, 12 were confirmed to have recurrent lesions. The diagnostic accuracy were 100.0% (12/ 12) for sensitivity, 70.0% (7/10) for specificity, and 86.4% (19/22) for accuracy, respectively. A higher SUVmax in malignant than benign lesion was noted (6.27 ± 3.42 vs 3.92 ± 2.24), though not reached to the significance (t = 1. 862, P > 0.05). (2) For extra-gastric lesion detection, the sensitivity, specificity, and accuracy for region lymph nodes were 78.9% (15/19), 92.3% (24/26), and 86.7% (39/ 45), for peritoneal spreading were 6/9, 97.2% (35/36), 91. 1% (41/45), and for distant sites were 86.7%(13/15), 93.3% (28/30), 91.1% (41/45). (3) False positive were found in eight sites. All were either inflammatory or physiological uptake at intestine. False negative were found in nine sites. Either due to small in size (less than 1.0 cm in diameter), well differentiation of the tumor cell or with a nature of signet ring. Conclusion 18F-FDG PET/CT had a potential to detect local, regional, and distant metastasis in gastric cancer.  相似文献   
22.
Objective To assess the feasibility of [18F ] fluoroerythronitroimidazole (18F-FETNIM ) with integrated positron emission tomography and computed tomography (PET-CT) imaging in detection of hypoxia in non-small-cell lung cancer ( NSCLC) patients. Methods Forty-two patients with newly diagnosed NSCLC underwent 18F-FETNIM PET-CT before treatment. Nineteen patients rested for approximately 120 minutes before undergoing PET-CT,23 patients underwent 2 sequential PET-CT scans at 60 minutes and 120 minutes after intravenous injection 18F-FETNIM. 18F-FETNIM uptake was quantified by calculating the maximum standardized uptake value in the tumor (SUVmax-T) and contralateral normal lung tissue (SUVmax-N). Regions of interest (ROIs) were drawn in the tumor and contralateral position and the radioactivity ratio of tumor to normal (T/N) was calculated.Results SUVmax-T ( 2. 43 ± 1. 34) was significantly higher than SUVmax-N (0.87 ±0.46, P<0.001) at 120 min. SUVmax-T (2. 80 ± 1.09) and SUVmax-N (1. 16 ± 0. 56) at 60 min were significantly higher than SUVmax-T (2. 61 ± 1. 10) and SUVmax-N (P<0.01) at 120 min. T/N (2.56 ± 0.71) at 60 min was higher than that at 120 min (2.48 ± 0.60),but the difference between them was not significant (P =0.324). Conclusion Our results indicate that 18F-FETNIM PET-CT may be a useful tool for evaluating hypoxia and may be a means to target specifically tumor cells resistant to conventional treatment before and during ongoing therapy in NSCLC.  相似文献   
23.
Objective PET with 18F-fluorodeoxyglucose (FDG) has been used to beth detect and stage a variety of malignancies. The aim of this retrospective study was to evaluate the clinical value of 18F-FDG PET/CT for recurrence and metastasis in gastric carcinoma patients after total gastrectomy. Methods A total of 45 gastric carcinoma patients who underwent total gastrectomy were included. PET/CT scans were obtained for restaging. The " gold standard" of 18F-FDG PET/CT diagnostic accuracy was based on either histopathology or clinical follow-up. By using the t-test from SPSS 11.5, the cut-off of maximum standard-ized uptake values (SUVmax) from 18F-FDG to differentiate benign from malignant lesion at stomach were determined and calculated. Results (1) Of the 45 patients, 22 were suspicion recurrent lesion at stomach. Of the 22 patients, 12 were confirmed to have recurrent lesions. The diagnostic accuracy were 100.0% (12/ 12) for sensitivity, 70.0% (7/10) for specificity, and 86.4% (19/22) for accuracy, respectively. A higher SUVmax in malignant than benign lesion was noted (6.27 ± 3.42 vs 3.92 ± 2.24), though not reached to the significance (t = 1. 862, P > 0.05). (2) For extra-gastric lesion detection, the sensitivity, specificity, and accuracy for region lymph nodes were 78.9% (15/19), 92.3% (24/26), and 86.7% (39/ 45), for peritoneal spreading were 6/9, 97.2% (35/36), 91. 1% (41/45), and for distant sites were 86.7%(13/15), 93.3% (28/30), 91.1% (41/45). (3) False positive were found in eight sites. All were either inflammatory or physiological uptake at intestine. False negative were found in nine sites. Either due to small in size (less than 1.0 cm in diameter), well differentiation of the tumor cell or with a nature of signet ring. Conclusion 18F-FDG PET/CT had a potential to detect local, regional, and distant metastasis in gastric cancer.  相似文献   
24.
目的 探讨18F-脱氧葡萄糖(18F-FDG)和18F-赤硝基咪唑(18F-FETNIM)双示踪剂PET-CT确定头颈部肿瘤生物适形调强放射治疗(BIMRT)靶区的可行性。方法 经病理证实且未经治疗的头颈部肿瘤患者12例,治疗前行CT模拟定位扫描、18F-FDG PET-CT和18F-FETNIM PET-CT扫描,分别勾画大体肿瘤靶区(GTVCT)、葡萄糖代谢亚靶区(GTVFDG)、乏氧亚靶区(GTVFETNIM),测量并比较原发肿瘤和转移性淋巴结体积,分别表示为GTVP-CT、GTVN-CT、GTVP-FDG、GTVN-FDG、GTVP-FETNIM 和GTVN-FETNIM 结果 12例患者原发肿瘤和转移淋巴结均摄取18F-FDG,SUVmax-P和SUVmax-N分别为12.3±5.5和 5.1±2.8。9例患者原发肿瘤摄取18F-FETNIM,其中5例患者转移性淋巴结有摄取,未见摄取4例;3例患者原发肿瘤未见18F-FETNIM 摄取,其中转移性淋巴结有摄取1例,未见摄取2例。GTVP-CT、GTVP-FDG 和GTVP-FETNIM分别为 (22.23±12.11)、(20.83±11.59)和(1.98±1.81)cm3,GTVN-CT、GTVN-FDG 和GTVN-FETNIM分别为 (10.77±8.87)、(10.41±8.61)和(0.61±1.08)cm3。GTVP-FETNIM < GTVP-CT,GTVP-FETNIM < GTVP-FDG,GTVN-FETNIM < GTVN-CT,GTVN-FETNIM < GTVN-FDGP<0.01),GTVP-CT与GTVP-FDG、GTVN-CT与GTVN-FDG差异无统计学意义。结论 不同示踪剂PET-CT显像反映肿瘤细胞不同方面的生物学信息,根据PET-CT影像所显示的示踪剂高摄取区域将肿瘤组织划分为若干个子区域是可行的,为实现生物调强放疗提供了可靠的研究基础。  相似文献   
25.
目的探讨肺蜂窝病变的HRCT表现及其病理基础和临床意义。方法搜集具有肺蜂窝病变的3组不同种类病例60例,分析蜂窝及伴随征象的HRCT表现。对具有蜂窝表现的尸检肺标本6例行HRCT-病理对照研究。结果肺蜂窝为类圆形的含气腔隙,病理上,囊壁由病变残存的肺固有结构及增生的纤维成分构成。蜂窝囊径较小(58例,90.6%属于小囊组),具有下肺野(47例,71.9%)、肺周围(52例,81.3%)分布趋势,但在不同疾病存在差异。蜂窝可增大。形成后不可恢复。结论肺蜂窝为多层排列的囊腔,囊壁由多种成分构成,为肺纤维化终末表现,在3组不同临床病例中的HRCT表现存在差异。  相似文献   
26.
患者男,46岁,因“间断痰中带血2个月余”行胸部CT,结果示双肺内见多发圆形“磨玻璃”样影,边缘模糊,大者直径约1.5cm,中心均见点状致密影;增强扫描点状高密度影可见强化。为明确病变性质,2009年11月18日全身麻醉下行胸腔镜右肺活组织检查,见右肺表面散在数处暗红色斑片状出血点,分别在中叶外侧段、下k叶外基底段切取肺组织,  相似文献   
27.
Objective PET with 18F-fluorodeoxyglucose (FDG) has been used to beth detect and stage a variety of malignancies. The aim of this retrospective study was to evaluate the clinical value of 18F-FDG PET/CT for recurrence and metastasis in gastric carcinoma patients after total gastrectomy. Methods A total of 45 gastric carcinoma patients who underwent total gastrectomy were included. PET/CT scans were obtained for restaging. The " gold standard" of 18F-FDG PET/CT diagnostic accuracy was based on either histopathology or clinical follow-up. By using the t-test from SPSS 11.5, the cut-off of maximum standard-ized uptake values (SUVmax) from 18F-FDG to differentiate benign from malignant lesion at stomach were determined and calculated. Results (1) Of the 45 patients, 22 were suspicion recurrent lesion at stomach. Of the 22 patients, 12 were confirmed to have recurrent lesions. The diagnostic accuracy were 100.0% (12/ 12) for sensitivity, 70.0% (7/10) for specificity, and 86.4% (19/22) for accuracy, respectively. A higher SUVmax in malignant than benign lesion was noted (6.27 ± 3.42 vs 3.92 ± 2.24), though not reached to the significance (t = 1. 862, P > 0.05). (2) For extra-gastric lesion detection, the sensitivity, specificity, and accuracy for region lymph nodes were 78.9% (15/19), 92.3% (24/26), and 86.7% (39/ 45), for peritoneal spreading were 6/9, 97.2% (35/36), 91. 1% (41/45), and for distant sites were 86.7%(13/15), 93.3% (28/30), 91.1% (41/45). (3) False positive were found in eight sites. All were either inflammatory or physiological uptake at intestine. False negative were found in nine sites. Either due to small in size (less than 1.0 cm in diameter), well differentiation of the tumor cell or with a nature of signet ring. Conclusion 18F-FDG PET/CT had a potential to detect local, regional, and distant metastasis in gastric cancer.  相似文献   
28.
Objective PET with 18F-fluorodeoxyglucose (FDG) has been used to beth detect and stage a variety of malignancies. The aim of this retrospective study was to evaluate the clinical value of 18F-FDG PET/CT for recurrence and metastasis in gastric carcinoma patients after total gastrectomy. Methods A total of 45 gastric carcinoma patients who underwent total gastrectomy were included. PET/CT scans were obtained for restaging. The " gold standard" of 18F-FDG PET/CT diagnostic accuracy was based on either histopathology or clinical follow-up. By using the t-test from SPSS 11.5, the cut-off of maximum standard-ized uptake values (SUVmax) from 18F-FDG to differentiate benign from malignant lesion at stomach were determined and calculated. Results (1) Of the 45 patients, 22 were suspicion recurrent lesion at stomach. Of the 22 patients, 12 were confirmed to have recurrent lesions. The diagnostic accuracy were 100.0% (12/ 12) for sensitivity, 70.0% (7/10) for specificity, and 86.4% (19/22) for accuracy, respectively. A higher SUVmax in malignant than benign lesion was noted (6.27 ± 3.42 vs 3.92 ± 2.24), though not reached to the significance (t = 1. 862, P > 0.05). (2) For extra-gastric lesion detection, the sensitivity, specificity, and accuracy for region lymph nodes were 78.9% (15/19), 92.3% (24/26), and 86.7% (39/ 45), for peritoneal spreading were 6/9, 97.2% (35/36), 91. 1% (41/45), and for distant sites were 86.7%(13/15), 93.3% (28/30), 91.1% (41/45). (3) False positive were found in eight sites. All were either inflammatory or physiological uptake at intestine. False negative were found in nine sites. Either due to small in size (less than 1.0 cm in diameter), well differentiation of the tumor cell or with a nature of signet ring. Conclusion 18F-FDG PET/CT had a potential to detect local, regional, and distant metastasis in gastric cancer.  相似文献   
29.
对66例结直肠癌术后临床可疑复发或转移的患者行全身PET/CT显像, 根据病理诊断、临床随访结果计算PET/CT诊断复发及转移的敏感性和特异性,并与CT平扫检查结果比较.结果 PET/CT诊断结直肠癌术后复发的灵敏性和特异性分别为100%、94.6%,CT平扫分别为82.3%、85.8%;诊断术后转移的灵敏性和特异性分别为97.0%、91.7%,CT平扫分别为83.5%、76.6%. 半定量法示复发者标准摄取18F-脱氧葡萄糖(18F-FDG)最大值明显高于良性病变者(P﹤0.01).认为 PET/CT诊断结直肠癌术后复发转移具有较高的灵敏度和特异度,是结直肠癌术后理想的影像监测手段.  相似文献   
30.
双时相18F-FDG PET显像用于肿瘤良恶性鉴别诊断   总被引:1,自引:0,他引:1  
目的探讨双时相^18F-FDG PET显像在肿瘤良恶性鉴别中的临床价值。方法52例单次显像难以鉴别病变性质的患者行双时相全身^18 F-FDG PET/CT显像,将显像结果与病理学检查结果对照。结果43例延迟显像SUV升高的患者中有39例经病理检查证实为恶性病变,4例为良性病变;9例延迟显像SUV降低的患者中有7例经病理检查证实为良性病变,2例为恶性病变。灵敏度为95.1%,准确性为88.5%,特异性为63.6%,阳性预测值为90.7%,阴性预测值为7/9例。结论双时相^18F—FDG PET对良恶性病变的鉴别具有较高的灵敏度和准确性。  相似文献   
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