中国汉族正常成人颞叶体积的高分辨率MRI测量

Objective To explore the morphological features of temporal lobe of healthy Chinese Han adults on the high-resolution MRI and provide morphological data of temporal lobe for the construction of database for Chinese Standard Brain.Methods This is a clinical multi-center study.Three hundred healthy Chinese volunteers (male 150, and female 150) recruited from 15 hospitals were divided equally into five groups according to their age, i.e., 18-30 ( Group A ), 31-40 ( Group B ), 41-50 ( Group C ), 51-60(Group D), 61-70( Group E).All subjects were scanned using T1WI 3D MPRAGE sequence and volumes of standardized temporal lobe were collected.The bilateral volumes of standardized temporal lobe were compared by variance analysis between male and female subjects and among five age groups.Results The mean volumes of left and right temporal lobe were (97 126±15 703) mm3 and (97 015±15 545) mm3 respectively for men, and (95 123±14 564) mm3 and (96 423±13 407) mm3 for women.The difference temporal lobe volume between male and female wasn't significant on the same side (F = 1.336, 0.127 ,P =0.249, 0.722).The left temporal lobe volumes of Group A-E were (93 873±13 351 ), (95 566±11 964), (10 1890±14 511 ), (93 972±14 050) and (95 636±19 864)mm3 respectively, and those on the right side were (93 409±10 984), (98 158±16 392), (102 079±15 112), (95 448±11 123 ) and (94 658±16 928) mm3.There were significant differences among 5 groups between left and right temporal lobe volume( F = 2.940, 3.514, P = 0.021, 0.008 ).Further pairwise comparison revealed that left and right temporal lobe volume in Group C is higher than those of Group A and D(P<0.05), while there were no significant differences between the other groups ( P > 0.05 ).Conclusion High-resolution MRI could offer detailed images and precise morphological data of temporal lobe, which provides morphological data of temporal lobe for the construction of database for Chinese Standard Brain.     

实验性大鼠恶性胸膜间皮瘤的病理演变过程

目的研究诱发性大鼠MPM发生、发展的病理形态学改变,认识其演变过程,提高诊断和鉴别诊断水平。方法Wistar大鼠100只作为实验组,右侧胸膜腔闭式染尘法注入石棉纤维混悬液40mg。从诱发注射后3个月开始,每隔1~3个月分批CT扫描,死亡或垂死动物尸体解剖,最后证实实验组MPM66只。结果30天以内为单层增生期,30天以后出现复层增生,110天出现多形性增生,285天产生MPM。镜下三种组织类型。另见细胞形态多样改变,35例免疫组化33例EMA及Vim阳性。结论间皮细胞在不同时期出现不同的增生性改变,并在致癌因素作用下发展为癌前增生性病变,最后演变成MPM。间皮细胞具有双向分化特征,构成了组织学类型的复杂性和特有的免疫组化特点。这种特点不仅在阐明肿瘤的组织发生上有理论意义,且有临床实用价值,可用于诊断和鉴别。     

脑血管病患者神经肽Y的临床研究

目的观察脑出血（CH）、脑梗死（CI）、蛛网膜下腔出血（SAH）患者神经肽Y（NPY）水平动态变化及其临床意义。方法选择脑血管病（CVD）患者138例,其中CH组46例,CI组62例,SAH组30例。用放免法检测血浆NPY浓度。结果CI组、CH组、SAH组NPY水平显著高于对照组,于发病后24h内均显著升高,1～3d或4～7d达高峰,8～15d开始下降,15d后仍在较高水平;重型与大灶组显著高于中、轻型与小灶组;发病积分≥6分组显著高于<6分组,伴高血压组显著高于不伴高血压;伴消化道出血组显著高于不伴消化道出血组。结论NPY参与了CVD及其伴发病的病理生理过程。     

新生儿重症监护室医院感染危险因素及对策

目的为了提高新生儿重症监护室的工作质量,预防医源性感染的发生,探讨新生儿监护室感染成因及对策。方法分析新生儿病房管理的危险因素,采取相应的管理对策。结果通过建立健全各项管理规章制度,操作规程、消毒隔离、质量管理、医疗器械、设备管理及合理使用抗菌药物等。结论有效保障新生儿病房工作质量,切实降低了医源性、内源性感染的发生。     

真假“心流感”

近日,关于H7N9的新闻报道铺天盖地,人们的视线又再次聚焦在了流感上.咳嗽、发热、胸闷、气喘,与有着这些实实在在症状的一般流感相比,无声无息的“心流感”,而那些发生在心理．精神层面的疾病一更像是隐形的病魔。     

结核性中耳炎1例

患者男,26岁.半年前右耳进水后出现右耳痒、痛,渐出现右耳流脓并听力下降,偶有眩晕,抗炎治疗后好转,近日右耳出现部分血性分泌物.耳科检查:双侧耳廓无畸形,左外耳道通畅,右侧外耳道见液体分泌物、内见少量肉芽组织.血常规正常.MRI见右侧中耳乳突区不规则长T1长T2混杂信号病变,增强扫描病变区不均匀及多小房状强化,病变边缘强化毛糙,病变局部边缘与硬脑膜融为一体,鼓室盖部分破坏,颅内无异常.右上颈部见多发结节病灶,呈环形强化(图1,2).     

CT联合血清SMRP早期诊断大鼠恶性胸膜间皮瘤的研究

目的:探讨CT联合血清可溶性间皮素相关蛋白(SMRP)在提高早期诊断恶性胸膜间皮瘤(MPM)中的价值,为早期诊断MPM提供实验依据及理论基础.方法:采用右侧胸腔注射青石棉纤维混悬液诱发大鼠MPM,对大鼠行胸腹部CT平扫及增强扫描,对病变进行CT分期,并比较CT对MPM不同分期的诊断价值.分析不同分期MPM的SMRP表达...     

人体乳腺硬癌癌细胞器形态结构的定量研究

目的:区分乳腺正常细胞器和各期乳腺癌细胞器之间的差异,从而建立检查量化指标。方法:本文对女性乳腺硬癌癌细胞器线粒体,溶酶体的16个形态参数进行体视学统计分析。结果:发现癌细胞与正常细胞比较,其线粒体、溶酶体的体积、表面积和面数密度等形态参数存在高度显著差异和显著差异。结论:探讨了癌细胞的线粒体,溶酶体形态变异与功能之间的关系,为乳腺癌临床诊断提供了重要的定量依据。     

实验性大鼠癫痫模型异常脑电波及及物理特征

本文研究了局灶性及全身性青霉Ｇ钠诱发大鼠癫痫模型异常脑电波及其物理参量特征性改变特点。采用１７０Ｕ青霉素Ｇ钠置于大鼠硬脑膜外表面诱发癫痫发放是制成局灶性癫痫模型，腹腔注射１，２００，０００Ｕ青霉素诱发大鼠急性全身癫痫模型。癫痫放电的型式有：棘波、尖波、棘慢波综合、高幅失律等，施加处理因素后可以经起癫痫放电频率、振幅、左右对称性、正、负波相们比例以及癫痫放电型式的改变。