“一对一”全程助产护理联合放松疗法在初产妇中的应用效果

目的：探讨“一对一”全程助产护理联合放松疗法在初产妇中的应用效果。方法：选取2019年1月-2021年12月电子科技大学医学院附属绵阳医院·绵阳市中心医院妇产科住院的初产妇120例为研究对象,根据数字随机表法将其分为对照组与观察组,每组60例,其中对照组给予妇产科临床常规护理,观察组在对照组的护理基础上给予“一对一”全程助产护理联合放松疗法,比较两组疼痛程度、产程时间、分娩方式、妊娠结局及应激激素水平。结果：观察组阴道顺产率为86.67%,阴道助产率10.00%,剖宫产率为3.33%,对照组为61.67%、23.33%、15.00%,差异有统计学意义(P<0.05);观察组阴道分娩产妇无疼痛14例,轻度疼痛22例,中度疼痛21例,重度疼痛1例,对照组无疼痛3例,轻度疼痛8例,中度疼痛24例,重度疼痛16例,差异有统计学意义(P<0.05);观察组第一产程、第二产程、第三产程及总产程均较对照组短(P<0.05);观察组产后出血1例,新生儿窒息1例,对照组胎盘早剥4例,产后出血7例,新生儿窒息8例,差异有统计学意义(P<0.05);分娩后,两组应激激素水平均上升,但...     

Gabapentin effectively alleviates pain sensitization and regulates CACNA2D1 expression in postherpetic neuralgia rats北大核心CSCD

Aim To identify the molecular target of gabapentin in the treatment of postherpetic neuralgia(PHN). Methods The molecular target of gabapentin for PHN was analyzed by network pharmacology and molecular docking and confirmed by coprecipitation test. Rats were randomly divided into control group, model group, model+50 mg·kg-1 gabapentin group, model+100 mg·kg-1 gabapentin group, and model+200 mg·kg-1 gabapentin group, with nine rats in each group. The pain-related behaviors of the rats were measured at different time points. The mRNA and protein expressions of CACNA2D1, Bax, and Bcl-2 in rat spinal cord were determined by immunofluorescence, Western blot, and qPCR. Results CACNA2D1 was the target gene of gabapentin that determined via network pharmacology, molecular docking, and co-precipitation tests. After modeling, mechanical pain threshold and thermal pain threshold significantly decreased, and the number of apoptotic GABA cells significantly increased. However, after intraperitoneal injection of 50, 100, and 200 mg·kg-1 gabapentin, mechanical pain threshold and thermal pain threshold significantly increased(P<0.05), and the number of apoptotic GABA cells significantly decreased(P<0.01). Immunofluorescence and Western blot results showed that compared with the model group, with the increase of gabapentin concentration, the positive expression rate of Bax significantly decreased, and the positive expression rate of Bcl-2 and CACNA2D1 significantly increased. The mRNA expression levels of Bax, Bcl-2 and CACNA2D1 detected by qPCR were consistent with the results of immunofluorescence and Western blot. Conclusions Gabapentin up-regulates the expression of target protein CACNA2D1, inhibits the proapoptotic protein Bax, and promotes the expression of apoptotic inhibitor Bcl-2. © 2023 Publication Centre of Anhui Medical University. All rights reserved.     

脓疱疮继发传染性湿疹样皮炎1例

<正>脓疱疮是一种常见的浅表皮肤感染性疾病，这种感染具有自限性，通常会在几个星期内自行消退而不留瘢痕^[1]。由脓疱疮继发传染性湿疹样皮炎的病例在临床上容易误诊，我院治疗脓疱疮继发传染性湿疹样皮炎1例，疗效较好。1 病例报告患者，男，17岁。2021-11-30因双下肢起红斑、脓疱、黄痂，伴疼痛2个月来我院就诊。2个月前患者无明显诱因右下肢出现红斑、脓疱，逐渐增多。1个月前曾就诊于外院，治疗效果欠佳，仍有新发皮疹，渗液严重，