BIOEQUIVALENCE BETWEEN rhGH FOR RECONSTITUTION AND READY-TO-USE rhGH IN TWO LIQUID FORMULATIONS

Objective To evaluate the bioequivalence between recombinant human growth hormone （rhGH） for reconstitution, and two dosages of liquid formulation of rhGH [ （151U） 5mg or （301U） lOmg per 3ml ]. Methods The study drugs were tested in a randomized, single-blind and three-period crossover studies in 24 healthy male subjects. The three drugs were administered by subcutaneous injection at a dose of O. 21U/kg body weight. A continuous somatostatin infusion was given in order to suppress the secretion of endogenous GH. The ve- nous blood samples were drawn at different time points to test the serum concentration of GH. The pharmacokinetic parameters were analyzed by statistical methods. Results 90% confidence intervals （CI） of AUC0-24h among three products were all within 80% - 125% interval （ 103. 4% - 116. 5%, 105. 7% - 119. 6% and 91.9% - 103. 7%, respectively）, and the Cls of C,~ among three products were all within 70% - 143% interval （91.9% - 114. 0%, 103. 7% -127. 2% and 81.6% -97. 4%, respectively）. There was no statisitical difference of tmax among all the three products. Conclusion These data demonstrate that there is bioequivalence between rhGH for reconstitution and two liquid formulations of rhGH.     

碘仿明胶海绵填塞牙槽窝预防干槽症的临床观察

目的：观察碘仿明胶海绵填塞牙槽窝对拔牙创面愈合的影响。方法：选取临床拔除磨牙的病例，分为对照组拔290颗牙，用药组310颗牙。对照组拔牙后拔牙创面咬无菌干棉条30分钟止血，用药组碘仿明胶海绵填塞牙槽窝后。咬无菌干棉条30分钟止血。术后7天复诊，观察拔牙创面愈合情况。结果：(1)对照组干槽症的发病率为6．2％，用药组干槽症的发病率为0．3％。(2)牙槽窝的大小和创伤大小是引起干槽症的主要原因。结论：牙槽窝局部填塞碘仿明胶海绵可预防干槽症的发生。     

农村儿童营养性贫血的群体防治

无锡县通过对3月—7岁儿童4次横断面调查及3次干预、使农村儿童贫血患病率由40.86％下降到20％左右,IDA由16.78％下降到10％以下,Hb值均值上升7.4 g/L 不同干预措施的比较表明,健康教育组和铁剂预防组效果最为显著,开展健康教育、科学指导膳食是长期群体防治小儿营养性贫血经济有效,切实可行的重要措施。在开展科研的同时注重了科研成果的开发利用,在全县建立了贫血防治监测系统,1岁以内儿童贫血监测率达93.67％,健康教育工作也在试点乡以外地区广泛展开     

二维超声图诊断左房大血栓一例报告

患者,女,50岁,因反复心悸,气短13年,加重3月入院。13年前感关节痛、心悸。7年前X线胸透发现“心脏长大”,诊断为“心脏病”。经治疗无明显好转。3月前突感心悸加重,端坐呼吸不能平卧,咳嗽,曾两次住院均诊断为风心病,二尖瓣狭窄。经强心利尿治疗,效果不好。体检:端     

注射室护理医疗纠纷的防范

随着我国法制建设的不断深入，人民群众的法律意识不段增强，医疗服务行业相关的法律法规不断出台，特：别是《医疗事故处理条例》极其配套文件的颁布和实施，医疗纠纷则有了法律依据，面对不断突出的医患矛盾，如何用法律法规规范医疗行为，保护医患双方的合法权益成为我们面临的重要课题。对此，我们结合注射室护理工作的具体性质，制定了一些常识性的措施。     

慢性非特异性溃疡性结肠炎的辨证施护

慢性非特异性溃疡性结肠炎为临床常见病症,其病程缠绵,迁延难治,是比较顽固的疾病。临床以泄泻、腹胀、腹痛、黏液便或泄泻与便秘交替为主证,属中医学泄泻、肠风、脏毒等范畴。发病原因有外感湿热、饮食不节、情志失调、脾胃虚弱和肾阳虚衰等。湿热之邪壅积中、下焦,使脾胃运化失常,升降失司,肠腑不能分清别浊,水谷混杂,并走大肠,湿热稽留而滞下。《景岳全书·泄泻》指出“泄泻之本无不由于脾胃”,可见导致本病发生的重要因素是湿热与脾胃功能的失调。现代医学检查,乙状结肠镜下可见黏膜充血水肿,血管不清,表面可见溃疡缺损或黏膜苍白缺血,X线下肠黏膜线增粗,但必须排除变态反应性结肠炎、肠痉挛和肠神经官能症,同时还必须与痢疾、霍乱相鉴别。