法莫替丁与H1受体拮抗剂联合治疗慢性荨麻疹124例疗效观察

124例单用H1受体拮抗剂治疗疗效差的慢性荨麻疹患，联合应用法莫替丁治疗4周，结果显示临床痊愈率和显效分别为85．4％和10．5％，表明法莫替丁与H1受体拮抗剂联合用于这类H1受体拮抗剂不能奏效的慢性荨麻疹患是一种有效的治疗方法。     

Differentiation of human epidermal stem cells into fibroblasts induced by TGF-β1 in vitro

Objective To investigate the correlation between human epidermal stem cell (hESCs) and hypertrophic scar or keloid. Methods Improved collagen Ⅳ-coated adhesion methods was used to isolate and culture the epidermal stem cells after neutral protease selectively digested the dermo-epidermal junctions. After the cells were cultured and expanded in vitro, and passage 3 hESCs were induced by different concentrations of TGF-β1 (0.1, 5.0, and 10.0 ng/ml). Morphological fea-tures and identification of these cells were meseasured by HE, Masson, immunohistochemical staining on the days 3 and 7, respectively. Results After induced by TGF-β1 for 3 and 7 days, the morpholo-gy of the epidermal stem cell (hESCs) was changed into fusiform shape, similar to fibroblasts. 70 % ofthe cell which was induced by TGF-β1 were blue stained in the cytoplasm by Masson stain, which is the distinctive method for collagen, suggesting collagen appeared or increased in the cells. The collagen concentrations in supernatants of hESCs were 0.4150±0.0014, 0.3380±0. 0020, and 0.3870±0.0020, much higher than that in control group (0.0780±0.0025) and normal skin fibro-blast group (0.15004±0.0051) (P<0.05). Immunohistochemical staining revealed that positive rates of these cells for anti-vimentin staining were more than (95.00±1.20)% in experiments and (5.70±0.20)% in control group. Conclusion The differentiantion of hESCs induced by TGF-β1 into fibro-blasts indicates that hESCs may play a role in the pathogenesis of hypetrophic scar and keloid.     

医源性痔瘘手术后遗症的预防

医源性痔瘘手术后遗症(或称远期并发症)是指由于行痔瘘手术时对肛管直肠解剖不熟悉或术式选择不当、适应症未能正确掌握,技术运用失当等所致症状和体征.由于痔瘘疾病有复发和再生可能,且术后还须有较好的功能,故术时须减少对肛周皮肤、肌肉、粘膜等的损伤.否则易致肛门直肠狭窄、肛门闭锁不全,粘膜脱垂及创口经久不愈等后遗证.为减少此类后遗症的发生,笔者就手术时应注意的问题谈一些不成熟的认识.     

全雄激素阻断治疗晚期前列腺癌

为了评价全雄激素阻断治疗晚期前列腺癌的疗效，采用双侧睾丸切除、Ｆｌｕｔａｍｉｄｅ和Ｆｉｎａｓｔｅｒｉｄ联合治疗Ｄ２期前列腺癌病人５例。随访１５～２０个月，结果ＰＳＡ均正常，前列腺体积缩小６１．２％～６９．３％，有显著性差异（Ｐ＜０．０１），骨转移灶缩小、部分消失，积水肾脏完全恢复正常，所有病人治疗后全部有效。表明全雄激素阻断对晚期前列腺癌有良好的治疗效果。提出在三个层次上阻断雄激素治疗晚期前列腺癌的策略。     

以高钙性肾病为突出表现的原发性甲状旁腺功能亢进1例

以高钙性肾病为突出表现的原发性甲状旁腺功能亢进１例大连医科大学附属第二医院肾内科（１１６０２３）尹永红麻军患者男，４２岁。以多饮、多尿２年，恶心、呕吐３个月为主诉入院。２年前出现烦渴、多饮，每日饮水量７５００～１００００ｍｌ，多尿、夜尿增多。未介意。...     

急诊气压弹道碎石治疗顽固性结石性肾绞痛

目的：探讨急诊气压弹道碎石对顽固性结石性肾绞痛的治疗效果。方法：对38例输尿管中下段结石所致顽固性肾绞痛采用气压弹道碎石。结果：38例肾绞痛均获缓解，碎石率100%，术中结石取尽17例。术后1周结石排出19例，结论：该方法切实可行，效果满意。尤对X线阴性结石及未育女性为首选。     

出生巨大儿及其体格智力发育的随访

本文就在国际和平妇幼保健院，1988年出生的部分巨大儿，于学龄前期进行体格检查及智力测试，其结果表明体格发育与对照组相比，巨大儿组体重明显高于对照组(P<0．01)。巨大儿组肥胖儿童占21．6％，对照组肥胖儿童占8．7%。智力测试对照组语言智商高于巨大儿组(P<0.05)，总智商无显著差异,但智商总水平对照组高于巨大儿组。本文认为优生优育，首先应该预防巨大儿的发生。     

三种方法修复纹眉失败的比较

纹眉失败的修补是目前各大医院比较新的美容项目。纹眉失败有以下几种情况①眉型设计欠妥，不适合受术者的脸型；③两侧眉毛高低不一致，所纹的眉毛脱离眉骨的正常位置；③纹眉液色料选择不理想，多见于眼线波纹刺到眉毛上，造成漆黑一片，黑中透蓝；④眉毛纹的没有层次感，眉头处理不理想，多见于圆形或方型眉头；⑤纹刺密度不均匀，缺乏柔和感；⑥纹刺深度不讲科学性，纹刺部位不讲艺术性。我们针对其不同程度，采取了三种修复方法，即空外密纹褪色法，洗眉水褪色法，高频电针电绕去色法，效果满意，现介绍如下。1＄廉资问1995－12～1996…