化瘀破癜胶囊对小鼠移植性肺癌化疗毒副作用的影响

目的:探讨化瘀破癥胶囊对肿瘤化疗毒副作用的影响。方法:以小鼠移植性Lewis肺癌为模型,分别观察化瘀破癥胶囊对顺铂(DDP)和环磷酰胺(Cy)所致荷瘤鼠体重以及Cy所致骨髓有桉细胞数下降的变化,并以参莲胶囊为对照。结果:化瘀破癥胶囊能显著增加DDP和Cy所致荷瘤鼠下降的体重,以及Cy所致下降的骨髓有核细胞数(P<0.01),且与参莲胶囊无显著性差异(P>0.05)。结论:表明化瘀破癥胶囊对动物移植性肺癌化疗所致骨髓抑制和体重下降有保护作用。     

治浊固本汤治疗慢性肾炎蛋白尿48例临床观察

目的 :观察治浊固本丸治疗慢性肾炎蛋白尿的疗效 .方法 :80例患者随机分为治浊固本丸治疗组 4 8例 ,肾炎四味片对照组 32例 ,分别给以治浊固本丸和肾炎四味片口服。治疗前后分别作尿蛋白定量、定性检测。结果 :治浊固本丸降低尿蛋白的总有效率为 89.6 % ,优于肾炎四味片 (P <0 .0 5 )。结论 :治浊固本丸能有效治疗慢性肾炎蛋白尿     

补肾化瘀解毒复方含药血清对肺癌A549/DDP耐药细胞周期的影响

目的 探讨补肾化瘀解毒复方含药血清对肺癌耐药细胞周期的影响.方法 采用血清药理学及流式细胞法,分析补肾化瘀解毒复方含药血清分别与顺铂(DDP)和维拉帕米(VRP)合用后A549/DDP耐药细胞周期的变化.结果 补肾化瘀解毒复方含药血清均能明显增加A549/DDP耐药细胞G0/G1期细胞数,减少S期和G2/M期的细胞比例(P＜O.05).结论 补肾化瘀解毒复方含药血清能使A549/DDP耐药细胞阻滞于G0/G1期,协同增强DDP和VRP阻止A549/DDP耐药细胞DNA的合成,抑制肺癌耐药细胞的分裂增殖.     

Pharmacological effects of serum containing chinese medicine Bushen Huayu Jiedu Compound Recipe (补肾化瘀解毒复方) in lung cancer drug-resistance cells

Objective： To explore the pharmacologic effects of Chinese medicine Bushen Huayu Jiedu Compound Recipe （补肾化瘀解毒复方,BSHYJDR） in drug-resistance cells of lung cancer. Methods： Human lung adenocarcinoma A549/DDP cell strain was selected, serum pharmacology and flow cytometer （FCM） method were adopted, $180 tumor-bearing mice and normal mice were given, through gastrogavage, different doses of a decocted concentration of BSHYJDR. Serum from the abdominal aorta was taken to observe the effect of drug-serum on cisplatin （DDP） concentration, free Ca^2＋ concentration and the expression of lung drug-resistance protein LRP-56 in A549/DDP cells. Results： Compared with the drug-resistance group, the intracellular DDP concentration in the group taking a high dose and the normal group of Chinese medicine showed significant difference （P〈0.05）, while no significant difference was found in the low-dose group （P〉0.05）. Compared with the drug-resistance group, the Ca^2＋ concentration in cells and the expression of LRP in lung cancer drug-resistance cells A549/DDP of the high-dose group, the low-dose group and the normal group of Chinese medicine were significantly different （all P〈0.01）, the LRP expression of the normal group was obviously higher than that of the drug-resistance group （P〈0.05）. Cenclusien： It was indicated that serum containing Chinese medicine BSHYJDR in the tumor-bearing mice and the normal mice had certainly different, tumor-bearing mice serum containing could improve drug concentration in lung cancer drug-resistance cells, prevent the inflow and release of Ca^2＋, and inhibit the expression of the drug-resistance gene in the lung cancer drug-resistance cells, which might be the mechanism of BSHYJDR in enhancing the efficacy in reversing and inhibiting tumor.     

化瘀破癥胶囊对荷瘤小鼠化疗所致骨髓抑制的保护作用研究

目的探讨化瘀破癥胶囊对肿瘤化疗所致骨髓抑制的保护作用。方法以小鼠移植性Lew is肺癌为模型,分别观察化瘀破癥胶囊对环磷酰胺(Cy)所致荷瘤鼠外周血象、骨髓有核细胞数下降的变化。结果化瘀破癥胶囊能显著增加Cy所致荷瘤鼠外周血下降的白细胞数(P<0.01),以及下降的骨髓有核细胞数(P<0.01)。结论化瘀破癥胶囊对动物移植性肿瘤化疗所致骨髓抑制有保护作用。     

化瘀破癥胶囊对动物移植性肺癌增效解毒作用的实验研究

目的：探讨化瘀破癥胶囊对肿瘤化疗的增效和解毒作用。方法：以小鼠移植性Lewis肺癌为模型,观察化瘀破癥胶囊与低剂量顺铂（DDP）联合应用时的抑瘤率,以及化瘀破癥胶囊对化疗药物顺铂（DDP）和环磷酰胺（Cy）的解毒作用。结果：化瘀破癥胶囊高剂量组有显著的抑瘤增效作用,化瘀破癥胶囊低剂量组无显著性差异,并且化瘀破癥胶囊能显著提高Lewis肺癌荷瘤鼠的体重和外周血WBC。结论：表明化瘀破癥胶囊对动物移植性肺癌化疗有协同增效和解毒作用。     

外剥内扎和横切纵缝加侧切术在环状痔中的应用

目的比较外剥内扎和横切纵缝加侧切术与外剥内扎和横切纵缝术治疗环状痔的疗效。方法将150例患者随机分为两组,每组75例,分别用两种方法治疗。结果两组患者在愈合天数无显著差异（P〈0.05）,在创缘水肿、疼痛天数、继发性肛裂、肛管狭窄有显著差异（P〈0.01）。结论外剥内扎和横切纵缝加侧切术在治疗环状痔方面的临床指标明显优于外剥内扎和横切纵缝术,临床上值得推广。     

改良经肛外直肠黏膜下层柱状注射术对Ⅰ、Ⅱ度直肠脱垂疗效的观察

目的探讨改良经肛外直肠黏膜下层柱状注射术对Ⅰ、Ⅱ度直肠脱垂的疗效。方法对60例Ⅰ、Ⅱ度直肠脱垂患者行改良经肛外直肠黏膜下层柱状注射术治疗。结果治疗后随访1年以上,痊愈58例,占96.67%;好转2例,占3.33%。结论改良经肛外直肠黏膜下层柱状注射术对Ⅰ、Ⅱ度直肠脱垂具有创伤小,操作简便,生效快,临床治愈率高,不易复发等优点。     

化瘀破癥胶囊对小鼠移植性肺癌化疗毒副作用的影响

目的：探讨化瘀破癥胶囊对肿瘤化疗毒副作用的影响.方法：以小鼠移植性Lewis肺癌为模型,分别观察化瘀破癥胶囊对顺铂（DDP）和环磷酰胺（Cy）所致荷瘤鼠体重以及Cy所致骨髓有核细胞数下降的变化,并以参莲胶囊为对照.结果：化瘀破癥胶囊能显著增加DDP和Cy所致荷瘤鼠下降的体重,以及Cy所致下降的骨髓有核细胞数（P＜0.01）,且与参莲胶囊无显著性差异（P＞0.05）.结论：表明化瘀破癥胶囊对动物移植性肺癌化疗所致骨髓抑制和体重下降有保护作用.