72例人工髋关节置换术疗效分析

目的探讨人工髋关节置换术的疗效。方法对72例（74髋）人工髋关节置换患者的临床疗效及手术相关问题进行随访和分析。结果49例（50髋）获得8-89（38.8±18.6）个月的随访,23例失访。49例随访期内3例死亡,发生深静脉血栓形成1例,人工髋关节脱位3例,假体无菌性松动3例,髋臼磨损2例。无术后感染病例。按照Harris髋评分系统对未翻修的45例（46髋）进行评分：优25髋,良12髋,中6髋,差3髋。结论人工髋关节置换术疗效确切,严格掌握手术适应证,规范手术操作,完善术后康复,预防和减少术后并发症,可提高手术疗效。     

镍钛记忆合金聚髌器治疗双髌骨骨折1例报道

髌骨骨折是常见的关节内骨折，约占全身骨骼损伤的1％，而对双髌骨骨折所占全身骨折的比例目前还没有统一标准的报道。髌骨骨折属于一种关节内骨折，手术应尽可能解剖复位，否则容易导致创伤性关节炎。     

健步虎潜丸含药血清对体外成骨样细胞增殖和功能的影响

BACKGROUND: More recently, the focus has been on searching for a compound Chinese medicine for reinforcing kidney, which cannot only inhibit bone absorption, but also promote osteogenesis to protect against osteoporosis. OBJECTIVE: To explore effects of drug serum of Jianbuhuqian pills on proliferation and function of osteoblast-like cells in vitro. METHODS: Twenty-four adult female Sprague-Dawley rats were randomly divided into low-dose, medium-dose, high-dose and normal saline groups, and given intragastric administration of 1.5, 3.0, and 6 g/kg Jianbuhuqian pills and equal volume of normal saline, respectively twice daily for 1 week. At 1 hour after final gavage, rats were decapitated to prepare drug sera used for culturing osteoblast-like cells. At 24, 48 and 72 hours of culture, the cellular morphology was observed, as well as the cell proliferation and alkaline phosphatase activity was detected by MTT assay and alkaline phosphatase staining, respectively. RESULTS AND CONCLUSION: Compared with the normal saline group, the cell density began to increase significantly in three Jianbuhuqian groups at 24 hours after culture, mitotic figures were easy to be observed, cells were in overlapping growth, much secretions and matrix accumulation appeared, especially in the high-dose group. The obsorbance values in Jianbuhuqian groups were significantly higher than that in the normal saline group. After 24 hours of culture, the obsorbance values in the medium-dose and high-dose groups were significantly increased compared with the low-dose group, and the values showed significant differences among three Jianbuhuqian groups after 48 and 72-hour culture. In addition, the alkaline phosphatase activity presented overt increase in the Jianbuhuqian groups compared with the normal saline group, and significant differences could be found among Jianbuhuqian groups. To conclude, the drug serum of Jianbuhuqian pills can promote the activity of osteoblast-like cells in a time- and concentration-dependent manner. 中国组织工程研究杂志出版内容重点：组织构建;骨细胞;软骨细胞;细胞培养;成纤维细胞;血管内皮细胞;骨质疏松;组织工程     

进行性骨化性肌炎研究现状

进行性骨化性肌炎(Myositis ossificans progres-siva,MOP)又叫进行性骨化性纤维发育不良(Fibro-dysplasia ossificans progressiva,FOP)是一种罕见的遗传性、进行性结缔组织疾患,以先天性拇趾畸形和进行性横纹肌异位骨化为特征。1692年Patin描述一位患者为“枯树枝样人”,而后来Munchmeyer第一次报道了该疾病,因此该病还可被称为Munchmeyer疾病,1868年由Von Busch命名为进行性骨化性肌炎[1]。它的特征性表现有对称性双侧拇趾(指)畸形及进行性软组织异位骨化,骨化发生的主要部位主要包括横纹肌、韧带、肌腱、筋膜及皮肤。国外统计其发…     

仙灵骨葆胶囊治疗股骨头缺血性坏死30例的临床观察

目的:观察仙灵骨葆胶囊治疗股骨头缺血性坏死的疗效。方法:回顾性分析30例(36髋)股骨头缺血坏死(Ⅰ-Ⅲ/FicatⅣ)应用仙灵骨葆胶囊治疗的临床资料.其中酒精性8例(10髋),激素性12例(16髋),创伤性6例,特发性4例。结果:根据北戴河髋关节功能评价4项6级标准:优≥80分6髋,良≥60分15髋,中≥40分11髋,差<40分4髋,总有效率88.9%。治疗X线征象好转3例,无变化27例,进展6例。结论:单纯采用仙灵骨葆胶囊治疗股骨头缺血坏死可稳定病情,对临床症状的改善有较好的疗效。