pT1期肺腺癌间质浸润的分级及预后意义

Objective To study the prognostic significance of grading system for stromal invasion in pathologic tumor stage Tl (pTl) adenocarcinoma of lung.Methods Eighty-five cases of surgically resected pTl lung adenocarcinoma with clinicopathologic and follow-up data were retrospectively reviewed.The degree of invasive growth was classified into three grades according to its location in the tumor.The clinicopathologic characteristics and prognostic significance were analyzed.Results Amongst the 85 cases studied,17 cases (20% ) were in grade 1,12 (14% ) in grade 2 and 56 (66% ) in grade 3.The tumor size was smaller and lymphovascular permeation was less frequently encountered in cases with grade 1 stromal invasion than in those with grade 3 (P =0.005 for tumor size and P =0.018 for occurrence of lymphovascular permeation).The rate of lymph node metastasis and pathologic staging in cases with grade 1 and grade 2 were similar and were significantly lower than those with grade 3 ( P = 0.007 for rate of lymph node metastasis in grade 1 versus grade 3 tumors,P = 0.002 for pathologic stage in grade 1 versus grade 3 tumors,P = 0.027 for rate of lymph node metastasis in grade 2 versus grade 3 tumors and P =0.021 for pathologic stage in grade 2 versus grade 3 tumors).There was no statistically significant difference with respect to age,gender and smoking history of the patients,amongst cases in different grades.The overall five-year survival rate was 63%.The five-year survival rates for cases with grade 1,grade 2 and grade 3 were 100% ,83.3% and 46.6% ,respectively.The difference between cases with grade 2 and grade 3 was statistically significant (P =0.027).The death rate during follow-up for cases with grade 1,grade 2 and grade 3 were 0,16.7% and 42.9% ,respectively.The difference between cases with grade 1 and grade 3 was statistically significant ( P - 0.001).Univariate analysis showed that grade of stromal invasion (P = 0.001),pathologic stage (P<0.001),presence of lymphovascular permeation (P < 0.001) and lymph node involvement　(P < 0.001) represented important prognostic factors.Multivariate analysis also showed that pathologic stage (P <0.001) was an independent prognostic factor.Conclusions The grading system of stromal invasion in pulmonary adenocarcinoma correlates with tumor prognosis and other prognostic factors.It represents a useful criterion in prognostic categorization of pTl adenocarcinoma of lung.     

pT1期肺腺癌间质浸润的分级及预后意义

Objective To study the prognostic significance of grading system for stromal invasion in pathologic tumor stage Tl (pTl) adenocarcinoma of lung.Methods Eighty-five cases of surgically resected pTl lung adenocarcinoma with clinicopathologic and follow-up data were retrospectively reviewed.The degree of invasive growth was classified into three grades according to its location in the tumor.The clinicopathologic characteristics and prognostic significance were analyzed.Results Amongst the 85 cases studied,17 cases (20% ) were in grade 1,12 (14% ) in grade 2 and 56 (66% ) in grade 3.The tumor size was smaller and lymphovascular permeation was less frequently encountered in cases with grade 1 stromal invasion than in those with grade 3 (P =0.005 for tumor size and P =0.018 for occurrence of lymphovascular permeation).The rate of lymph node metastasis and pathologic staging in cases with grade 1 and grade 2 were similar and were significantly lower than those with grade 3 ( P = 0.007 for rate of lymph node metastasis in grade 1 versus grade 3 tumors,P = 0.002 for pathologic stage in grade 1 versus grade 3 tumors,P = 0.027 for rate of lymph node metastasis in grade 2 versus grade 3 tumors and P =0.021 for pathologic stage in grade 2 versus grade 3 tumors).There was no statistically significant difference with respect to age,gender and smoking history of the patients,amongst cases in different grades.The overall five-year survival rate was 63%.The five-year survival rates for cases with grade 1,grade 2 and grade 3 were 100% ,83.3% and 46.6% ,respectively.The difference between cases with grade 2 and grade 3 was statistically significant (P =0.027).The death rate during follow-up for cases with grade 1,grade 2 and grade 3 were 0,16.7% and 42.9% ,respectively.The difference between cases with grade 1 and grade 3 was statistically significant ( P - 0.001).Univariate analysis showed that grade of stromal invasion (P = 0.001),pathologic stage (P<0.001),presence of lymphovascular permeation (P < 0.001) and lymph node involvement　(P < 0.001) represented important prognostic factors.Multivariate analysis also showed that pathologic stage (P <0.001) was an independent prognostic factor.Conclusions The grading system of stromal invasion in pulmonary adenocarcinoma correlates with tumor prognosis and other prognostic factors.It represents a useful criterion in prognostic categorization of pTl adenocarcinoma of lung.     

pT1期肺腺癌间质浸润的分级及预后意义

Objective To study the prognostic significance of grading system for stromal invasion in pathologic tumor stage Tl (pTl) adenocarcinoma of lung.Methods Eighty-five cases of surgically resected pTl lung adenocarcinoma with clinicopathologic and follow-up data were retrospectively reviewed.The degree of invasive growth was classified into three grades according to its location in the tumor.The clinicopathologic characteristics and prognostic significance were analyzed.Results Amongst the 85 cases studied,17 cases (20% ) were in grade 1,12 (14% ) in grade 2 and 56 (66% ) in grade 3.The tumor size was smaller and lymphovascular permeation was less frequently encountered in cases with grade 1 stromal invasion than in those with grade 3 (P =0.005 for tumor size and P =0.018 for occurrence of lymphovascular permeation).The rate of lymph node metastasis and pathologic staging in cases with grade 1 and grade 2 were similar and were significantly lower than those with grade 3 ( P = 0.007 for rate of lymph node metastasis in grade 1 versus grade 3 tumors,P = 0.002 for pathologic stage in grade 1 versus grade 3 tumors,P = 0.027 for rate of lymph node metastasis in grade 2 versus grade 3 tumors and P =0.021 for pathologic stage in grade 2 versus grade 3 tumors).There was no statistically significant difference with respect to age,gender and smoking history of the patients,amongst cases in different grades.The overall five-year survival rate was 63%.The five-year survival rates for cases with grade 1,grade 2 and grade 3 were 100% ,83.3% and 46.6% ,respectively.The difference between cases with grade 2 and grade 3 was statistically significant (P =0.027).The death rate during follow-up for cases with grade 1,grade 2 and grade 3 were 0,16.7% and 42.9% ,respectively.The difference between cases with grade 1 and grade 3 was statistically significant ( P - 0.001).Univariate analysis showed that grade of stromal invasion (P = 0.001),pathologic stage (P<0.001),presence of lymphovascular permeation (P < 0.001) and lymph node involvement　(P < 0.001) represented important prognostic factors.Multivariate analysis also showed that pathologic stage (P <0.001) was an independent prognostic factor.Conclusions The grading system of stromal invasion in pulmonary adenocarcinoma correlates with tumor prognosis and other prognostic factors.It represents a useful criterion in prognostic categorization of pTl adenocarcinoma of lung.     

骨质疏松性胸腰椎压缩骨折双侧穿刺经皮椎体成形术中不同层面穿刺对骨水泥分布与疗效的影响研究

目的 探讨双侧穿刺经皮椎体成形术治疗骨质疏松性胸腰椎压缩骨折中,不同层面穿刺对骨水泥分布与疗效的影响。方法 回顾分析2017年12月—2020年12月收治并符合选择标准的274例骨质疏松性胸腰椎压缩骨折患者临床资料,均行双侧穿刺经皮椎体成形术。根据术中C臂X线机侧位透视穿刺针针尖最终到达位置分组,118例双侧穿刺针针尖位于同一层面（A组）;156例双侧穿刺针针尖位于不同层面（B组）,其中87例分别位于上1/3层和下1/3层（B1组）,69例位于相邻层面（B2组）。A、B组间以及A、B1、B2组间患者性别、年龄、骨折节段、骨质疏松程度、病程以及术前疼痛视觉模拟评分（VAS）、Oswestry功能障碍指数（ODI）比较,差异均无统计学意义（P>0.05）。比较各组手术时间、骨水泥注入量、术后疼痛VAS评分及ODI,影像学复查骨水泥分布情况。结果 各组手术均顺利完成,未出现骨水泥渗漏导致神经压迫症状,无肺栓塞、穿刺针道感染发生。A、B组间以及A、B1、B2组间手术时间、骨水泥注入量比较,差异均无统计学意义（P>0.05）。患者术后均获随访,随访时间3～32个月,平均7.8个月;A...     

pT1期肺腺癌间质浸润的分级及预后意义

Objective To study the prognostic significance of grading system for stromal invasion in pathologic tumor stage Tl (pTl) adenocarcinoma of lung.Methods Eighty-five cases of surgically resected pTl lung adenocarcinoma with clinicopathologic and follow-up data were retrospectively reviewed.The degree of invasive growth was classified into three grades according to its location in the tumor.The clinicopathologic characteristics and prognostic significance were analyzed.Results Amongst the 85 cases studied,17 cases (20% ) were in grade 1,12 (14% ) in grade 2 and 56 (66% ) in grade 3.The tumor size was smaller and lymphovascular permeation was less frequently encountered in cases with grade 1 stromal invasion than in those with grade 3 (P =0.005 for tumor size and P =0.018 for occurrence of lymphovascular permeation).The rate of lymph node metastasis and pathologic staging in cases with grade 1 and grade 2 were similar and were significantly lower than those with grade 3 ( P = 0.007 for rate of lymph node metastasis in grade 1 versus grade 3 tumors,P = 0.002 for pathologic stage in grade 1 versus grade 3 tumors,P = 0.027 for rate of lymph node metastasis in grade 2 versus grade 3 tumors and P =0.021 for pathologic stage in grade 2 versus grade 3 tumors).There was no statistically significant difference with respect to age,gender and smoking history of the patients,amongst cases in different grades.The overall five-year survival rate was 63%.The five-year survival rates for cases with grade 1,grade 2 and grade 3 were 100% ,83.3% and 46.6% ,respectively.The difference between cases with grade 2 and grade 3 was statistically significant (P =0.027).The death rate during follow-up for cases with grade 1,grade 2 and grade 3 were 0,16.7% and 42.9% ,respectively.The difference between cases with grade 1 and grade 3 was statistically significant ( P - 0.001).Univariate analysis showed that grade of stromal invasion (P = 0.001),pathologic stage (P<0.001),presence of lymphovascular permeation (P < 0.001) and lymph node involvement　(P < 0.001) represented important prognostic factors.Multivariate analysis also showed that pathologic stage (P <0.001) was an independent prognostic factor.Conclusions The grading system of stromal invasion in pulmonary adenocarcinoma correlates with tumor prognosis and other prognostic factors.It represents a useful criterion in prognostic categorization of pTl adenocarcinoma of lung.     

右美托咪定对口腔癌术后患者留置气管导管耐受性的影响

目的:探讨右美托咪定对口腔癌术后患者留置气管导管耐受性的影响.方法:选取口腔癌手术患者80例,随机分为正常对照组(N组)和右美托咪定组(D组),每组各40例.2组均行常规麻醉诱导和维持,D组于麻醉诱导前给予1μg/kg负荷剂量的右美托咪定,术中泵注0.2～0.6μg/(kg·h)右美托咪定维持麻醉,术毕镇痛泵内给予1μ...     

建立病区助理服务新模式的实践和体会

随着新医改的启动,医疗卫生单位面临着新的机遇和挑战,如何体现以人为本的新医改精神,构建良好和谐的新型医患关系,成为我们当前亟待研究和解决的重要课题.我院是当地实力最强、规模最大的一所三级甲等综合性医院,核定病床1200张,年门诊接诊量100多万,年住院病人4万多,病人流动多、工作负荷大,使得医院在医疗服务过程中难以真正把以人为本的服务理念落到实处,不仪和谐的医患关系受到一定影响,医院的既有优势也难以在新医改实施后继续保持和扩大.     

糖尿病足的护理体会

糖尿病足是由于远端神经病变及各种不同程度周围血管病变而导致的足部感染、溃疡和／或深层组织破坏。中国糖尿病患者已达4000多万人，占世界糖尿病人群总数的1／5，患病率居世界第二位，其中，糖尿病足并发率高达15％，是截肢致残的主要原因，截肢后30d内死亡率达到10％。糖尿病足必然导致患者治疗时间更长、治疗费用更高，进一步增大治疗难度，从而大大降低患者生活质量。事实上，糖尿病足是可以预防和治疗的。     

肩下垫枕仰卧位时插管软镜在困难气道患者经鼻插管中的临床应用

目的：观察一般仰卧位和肩下垫枕仰卧位时插管软镜在困难气道患者经鼻插管中的临床应用,探讨插管体位对插管效果的影响。方法：选取行口腔颌面外科手术的困难气道患者168例,采用随机数字表法分为一般仰卧位组（对照组）和肩下垫枕的仰卧位组（实验组）,每组84例,全身麻醉下行经鼻气管内插管。记录2组患者首次插管成功率、总成功率、插管时间和插管时直接看到声门的比率,同时记录2组患者在麻醉诱导前、插管前、插管过程中和插管后1 min和5 min时平均动脉压（MAP）、心率（HR）和插管并发症。结果：实验组患者首次插管成功率（94.0%,79/84）明显高于对照组（71.4%,60/84）（P<0.01）;实验组患者插管总成功率（98.8%,83/84）与对照组（97.6%,82/84）比较差异无统计学意义（P>0.05）。与对照组比较,实验组患者插管时间明显缩短（P<0.01）,插管软镜通过鼻后孔后不需要调整按钮即能直接看到声门的比率明显升高（P<0.01）。与基础值比较,2组患者在插管前和插管过程中MAP和HR均明显降低（P<0.01）,插管后1 min和5 min时回到基础值（P>0.05）;2组患者在各时间点MAP和HR比较差异均无统计学意义（P>0.05）。术后2组患者明显咽痛、声音嘶哑和鼻出血等并发症的发生率比较差异无统计学意义（P>0.05）。结论：肩下垫枕可使插管软镜在困难气道患者经鼻插管中应用的成功率更高,用时更短。肩下垫枕仰卧位是插管软镜经鼻插管时一个较好的操作体位。