男子周期性鼻衄案

患者王××,男,22岁,本乡旺河头村农民。1985年4月19日诊。患周期性鼻衄已半年,约28天一次,每次3—4天,血色鲜红,量不甚多,曾用止血敏、安络血等药物治疗,其效不显,而前来我院诊治。刻下鼻衄初作,点滴而下,色红不紫,伴头晕头痛,口干口苦,饮食不     

甲亢性周期麻痹23例分析

目的：探讨甲亢性周期性麻痹（TPP）的临床特点。方法：对23例TPP进行回顾性分析和总结。结果：TPP占同期住院甲亢患者的6.2%,男女比例22∶1,21-40岁为发病高峰年龄,肌无力发作时23例血钾均低于正常。结论：TPP以肌无力伴低钾血症为其临床特点,及早诊治是关键。TPP患者的治疗应在补钾的同时加用抗甲状腺药物,可减少复发。对重度TPP进行心电监护、补钾、抗心律失常和呼吸机辅助呼吸是抢救成功的重要措施。     

宫腔镜引导疏通输卵管治疗阻塞性不孕

目的在宫腔镜引导下疏通输卵管治疗阻塞性不孕。方法选择经子宫输卵管造影证实不同程度的输卵管阻塞120例，于月经干净3-7d进行输卵管疏通术治疗（地塞米松注射剂5mg，庆大霉素注射剂8万U，糜蛋白酶注射剂4000U）。结果单侧输卵管治疗有效率83．9％，有改善16．1％。双侧输卵管阻塞治疗有效率51．4％，有改善18．9％，无效29．7％。结论官腔镜引导下能准确判断左右两侧输卵管开口的位置及治疗情况，提高了一次疏通命中率及治愈率，是一种微创、安全、有效的治疗方法。     

尿HCG阴性侵蚀性葡萄胎1例的彩色多普勒超声表现

患者22岁，已婚，主因停经3个月，发现下腹渐进性增大包块2．5个月，阴道2次少量出血来诊。既往月经规律，停经后半个月，发现耻骨联合上一渐进性增大、质硬包块．近20d生长迅速．并出现恶心、呕吐、头晕、乏力。5d前阴道少量出血2次．色较淡，3d前突然鼻腔出血2次，头晕、乏力加重。查体：T     

低蛋白饮食对环孢素A肾病大鼠肾间质纤维化的作用

Objective To investigate whether low-protein diet has protective effect on the progression of renal interstitial fibrosis in rats with cyclosporine A (CsA)-induced nephropathy. Methods Eighteen male Sprague-Dawley rats were randomly divided into three groups (6 rats in each group). The rats in control group (C group) received common diet; in model group (M group) low-salt diet; in intervention group (Ⅰ group) low-salt and low-protein diet. After diet adaptation period of one week, the rats in C group received subcutaneous injection of olive oil 1 mg/kg daily for 5 weeks, while M group and Ⅰ group subcutaneous injection of CsA (diluted into 25 g/L with olive oil) 1 ml/kg for 5 weeks. All the rats were sacrificed at the end of the 5th week. The food-intake and body weight were measured daily. The creatinine clearance (Ccr) was examined before rats were sacrificed. The semi-quantitative pathological analysis on kidney sections was performed. The mRNA and protein expression of transforming growth factor-β1 (TGF-βI) and type Ⅰ collagen (Col Ⅰ) in kidney tissue was determined with real time PCR and immunohistochemical staining, respectively. Results The food-intake and body weight of rats in M and I groups were significantly lower than those in C group (P<0.05). Compared with C group, the Ccr levels in M and Ⅰ groups were significantly reduced [(0.65±0.15) ml/min, (0.40+0.13) ml/min vs (1.55±0.29) ml/min, P<0.05], the relative fibrosis areas of kidney interstitium in M and I groups were significantly increased (3.60%±0.46%, 3.26%±0.75% vs 0.44%±0.24%, P<0.05), the mRNA and protein expression of TGF-β1 in M and I group was significantly up-regulated (by 2.6 and 3.1 times in mRNA and by 1.5 and 1.6 times in protein, respectively, P<0.05), and the mRNA and protein expression of Col Ⅰ in M and I groups was also significantly up-regulated (by 3.0 and 3.5 times in mRNA and by 2.3 and 2.1 times in protein, respectively, P<0.05). There were no significant differences between M and I groups in every parameters above-mentioned except the rat body weight and Ccr. Both the body weight and Ccr in Ⅰ group were significantly lower than those in M group (P<0.05). Compared with C group, the urine osmotic pressure in M group and in I group were deceased (for M group, P>0.05; for I group, P<0.05). Compared with C group, the serum cholesterol levels in M and I groups were significantly increased (P<0.05), and the serum phosphorus level in I group was significantly decreased (P<0.05). The levels of serum albumin and serum calcium of all three groups had no statistical differences (P>0.05). Conclusion Low-protein diet has no renoprutective effects on the rat model of cyclosporin A nephropathy, on the contrary, may induce body weight loss.     

菲立磁标记兔BMSCs自体移植脊髓后的核磁共振活体示踪及形态学研究

目的通过观察菲立磁标记兔骨髓源性神经干细胞(BMSCs)自体移植脊髓后的核磁共振活体示踪及形态,期待找到一种应用非侵袭性方法来识别、跟踪BMSCs的存活状态及与宿主组织整合情况的方法。方法无菌条件下股骨取骨髓,梯度密度离心法分离获取兔骨髓基质细胞;使用“Feridex-多聚赖氨酸复合物(FE-PLL)”标记骨髓基质细胞,采用普鲁士兰染色和台盼蓝排除实验等方法鉴定FE-PLL标记兔骨髓基质细胞的效率和细胞的活力;体外标记的细胞自体脊髓移植,磁共振、免疫组织化学染色和透射电镜检查。结果普鲁士蓝染色显示FE-PLL标记骨髓基质细胞胞质内出现细小的蓝色铁颗粒;与正常未标记的细胞相比较,FE-PLL标记对骨髓基质细胞的活力、增殖和分化等能力没有明显的影响;经菲立磁标记的兔BMSCs自体脊髓移植后,可在核磁共振上活体示踪。结论菲立磁与核磁共振联合可无创性活体标记检测移植的神经干细胞基本的存在部位、存在方式及其一些生物学特性,可以用来活体示踪移植的BMSCs。     

早期放射治疗并手术对瘢痕疙瘩的作用

INTRODUCTION In present days, treatment of keliod includes simple operation, radiation, drug therapy, immune therapy, laser therapy and freezing therapy, but their effects aren't satisfying. Operation combined with radiation on keliod has achieved satisfying effect.     

子宫颈环型电切除治疗宫颈病变78例分析

目的探讨宫颈环型电切术(LEEP)治疗宫颈病变的可行性。方法对门诊78例宫颈肥大、糜烂、赘生物、囊肿患者进行LEEP治疗,于术后2个月观察疗效。结果术后2个月治愈77例(98.7%),显效1例(1.3%)。结论LEEP对宫颈病变是一种快速、安全、微创、有效的治疗方法。     

丹参注射液对自发性高血压大鼠左室肥厚的影响

目的：探讨丹参对自发性高血压大鼠（SHR）左室肥厚的影响。方法：18只引种繁殖的雄性SHR随机分成三组，每组6只。对照1组育至第8周处死；丹参组从第8周给药，丹参粉针剂1g／（kg.d），腹腔注射，用药10周处死；对照2组从第8周开始用相同容量蒸馏水腹腔注射，第18周处死。测量各组大鼠尾动脉收缩压（SBP）及左心室重量指数（LVMI），应用HE、VG染色，结合计算机图像分析技术，检测心肌细胞的直径（TDM）和面积（CA）、心肌组织胶原体积比例（CVF）、血管周围胶原面积与管腔面积比例（PVCA）。三组间各指标进行显著性检验。结果：与对照1组比较，对照2组的SBP、LVMI、TDM、CA、CVF、PVCA显著增加；丹参组除SBP升高外，余指标与对照1组比较，无统计学意义；与对照2组比较差异有显著性意义，P〈0.05。结论：丹参注射液能预防自发性高血压大鼠左室肥厚的形成。     

椎-基底动脉供血不足性眩晕的中医治疗研究近况

椎—基底动脉供血不足（Vertebro-basilar insufficiency，VBI）性眩晕是一种常见的神经系统病症，本病多发生于40岁以上的中老年人，临床表现以发作性眩晕、恶心欲呕、共济平衡失调等为主要症状。其病症特点为反复发作，缠绵难愈，易导致急性脑血管疾病发生。因此，早期诊治是预防和降低急性脑血管病发生率的有效措施。近5年来，医学界对VBI性眩晕的研究日趋深入，特别是在治疗研究方面取得了较大进展，现将有关中医对此的临床研究近况综述如下。