四氯化碳致肝损伤对小鼠血清TNF-α IL-6的影响

目的探讨四氯化碳(CCl4)致肝损伤模型小鼠血清TNF-α、IL-6水平的变化与肝损伤的相关性.方法紫外分光光度法分别测定血清ALT和肝匀浆MDA含量,放免法测定血清TNF-α、IL-6水平.结果单次或多次ip四氯化碳均可复制肝损伤模型,小鼠肝指数增加,血清ALT、肝匀浆MDA水平升高(P<0.01).病理组织学检查可见显著改变,IL-6水平未见显著变化,而血清TNF-α水平差异明显.单次四氯化碳给药模型组TNF-α水平降低,多次四氯化碳给药模型组TNF-α水平升高(P<0.01).结论四氯化碳致小鼠肝损伤模型,血清TNF-α的降低和升高可能与TNF-α作用的双重性,四氯化碳的作用机制,血清生化指标与病理组织变化的时间差异性及肝损伤的严重程度有关.     

折断式加压螺纹钉治疗股骨颈骨折

股骨颈骨折内固定的手术方法种类繁多，现趋向于安全、简单、可靠。本科从１９９２年至今应用折断式加压螺纹钉治疗股骨颈骨折８４例取得了满意疗效。１临床资料本组８４例，男５２例，女３２例，年龄１９～９３岁，平均年龄５４．２岁。骨折类型：头下型８例，经颈型５０...     

甘南县1996年布病暴发调查

甘南县１９９６年布病暴发调查康殿财１李卫星１齐欣１壮立辉２关晓山３１９９６年２月２０日至５月１０日，甘南县长山乡迎春村二屯发生一起布病的暴发流行，发病１５例（其中外地２例），罹患率为４．３５％。现将调查情况报告如下。迎春村位于长山乡东南４公里处，共４...     

以肺部游走性阴影为主要表现的遗传性出血性毛细血管扩张症1例

以肺部游走性阴影为主要表现的遗传性出血性毛细血管扩张症１例张云辉患者、男、１９岁，学生。因咳血半年入院。患者于１９９２年１２月，无诱因出现咳血，１０ｍｌ／日，胸片示右肺上野有－２ｃｍ×３ｃｍ之阴影，诊为肺结核，给链霉素、乙胺丁醇、异烟肼抗痨治疗３个月...     

抗精神病药与抗抑郁药的副反应

抗精神病药与抗抑郁药的副反应朱道省刘蔚唐辉蒋永红俞柏润夏碧磊满宏长郑崇芬向虎白克镇王玉冰聂文书徐广军王升明陈福新刘志纯邱义平朱永红苏琴黄东黄航黄晴韦立芳徐红丽王兴成陈荣民安翠霞徐立志陈光敏陈锦秀范新刚王玉风本刊编辑部综合编辑：抗精神病药与抗抑郁药的副...     

工矿企业职工家庭健康教育模式调查

在工厂中进行职工家庭健康教育，能增强职工的自我保健意识和自我保健能力，改变不健康的行为，增强人们的身心健康，从而促进工厂的生产。因此，特进行一次效果调查及健康教育效果评价等研究工作。1内容与方法1．1调查对象健康教育目标人群选择某厂在居住条件、人口构成、文化程度、生活方式、经济状况基本相似的200个职工家庭，799人为调查对象。1．2干预方法的实施1．2．1调查工作调查内容包括家庭成员的一般情况和家庭的经济状况、卫生设施；家庭成员的体质、医疗卫生保健、卫生行为、生活方式及对日常生活、卫生、营养、除害灭病、吸烟…     

受微波高频辐射人员外周血5—羟色胺含量的变化

The relationship between 5-HT contents in peripheral blood and power density among workers exposed to microwave or high frequency radiation in the workshops were studied. At the same time, systems and disorder of central nervous system and cardiovascular system were examined. The results of study showed that the average 5-HT content in whole blood for high frequency radiation exposure group was lower than that of the control, but without statistical significance. Value for the microwave exposure group was significantly lower than that of the control (P less than 0.01). The 5-HT content of mechanical maintainers exposed to microwave of high frequency radiation were all lower than the contents of their corresponding control groups (P less than 0.01). But for the mechanic operators as compared with their corresponding control, no significant difference was found (P greater than 0.05). The power density exposed by the maintainers of both tested groups were all higher than that of the operators. The 5-HT contents in the whole blood were inversely proportional to the power density of microwave and high frequency groups. The incidence of neurasthenic syndrome, unsymmetric skin temperature in both limbs and hypotension was higher in the microwave and high frequency radiation groups than that in the control group. The incidence of bradycardia and some abnormal items of electrocardiograph in the microwave group was obviously greater than that in high frequency group, which may be related to different frequency exposed for these two exposure groups. Whether it is related to the contents of 5-HT needs further investigation.     

重型病毒性肝炎中丁型肝炎病毒的检测

为了探讨丁型肝炎病毒（ＨＤＶ）感染在重型病毒性肝炎中的作用，对北京佑安医院１９８０年至１９８９年收治的５４例急性和亚急性重型肝炎和３８例急性乙肝患者血清，应用国产ＨＤＶＥＬＩＳＡ试剂测定抗－ＨＤ、抗－ＨＤＩｇＭ和ＨＤＡｇ，应用斑点杂交技术测定ＨＤＶＲＮＡ。结果发现重型肝炎组ＨＯＶ－Ｍ检出率明显高于急性乙肝组（２７．８％比５．３％．Ｐ＜０．０５）。单独ＨＢＶ感染和ＨＤＶ／ＨＢＶ混合感染的重型肝炎患者均有较高的病死率。提示ＨＤＶ感染是重型肝炎中重要的病原学因素之一，ＨＤＶ与ＨＢＶ具有协同作用加重肝损害，导致肝衰竭。     

缺血性股骨头坏死患者血清透明质酸及层粘连蛋白的研究

为探讨细胞外间质主要成分透明质酸（ＨＡ）与层粘连蛋白（ＬＮ）在缺血性股骨头坏死（ＩＮＦＨ）中的生理病理过程及临床价值，采用放射免疫分析法对４５例不同病因的ＩＮＦＨ患者进行了血清ＨＡ与ＬＮ的定量分析，并与３０例正常人对照。结果显示，ＩＮＦＨ患者血清ＨＡ含量极显著地高于对照组（ｔ＝３－２９；Ｐ＜０－０１）。尤以激素性ＩＮＦＮ增高最为显著（ｔ＝３－６２；Ｐ＜０－０１）。ＩＮＦＨ患者ＬＮ含量亦明显高于对照组（ｔ＝２－８４；Ｐ＜０－０１）。同时，ＨＡ与ＬＮ含量增高与病程发展密切相关。故定量检测ＨＡ与ＬＮ可作为ＩＮＦＨ早期诊断及判断预后的良好指标