影响人工耳蜗植入术后效果的相关因素

人工耳蜗植入是目前重度、极重度感音神经性听障患者重要的康复方式,术后效果至今仍存在较大的个体差异。本文分析了人工耳蜗植入术后效果的影响因素,以期在现有技术水平上为提高患者术后的言语识别率提供帮助,并使术者、患者及其家属对术后效果建立合理预期。     

比亚芬联合常规药物保留灌肠治疗放射性直肠炎的疗效对比研究

目的观察比亚芬联合常规药物保留灌肠治疗宫颈癌放射治疗后并发急性直肠炎的疗效。方法将89例经放射治疗后并发急性放射性直肠炎的宫颈癌患者随机分为实验组和对照组,保留灌肠,观察两组在疗效方面的区别。结果实验组有效率93.3%%,对照组有效率72.4%%,两组比较有显著差异。(P<0.05)。结论应用比亚芬联合常规药物保留灌肠治疗急性放射性直肠炎效果显著。     

CYP2C19 Polymorphism and Clinical Outcomes among Patients of Different Races Treated with Clopidogrel:A Systematic Review and Meta-Analysis

Several studies have investigated the association between CYP2C19 polymorphism and clinical outcomes of patients treated with clopidogrel, but few have noticed the difference in association between Westerners and Asians. We searched MEDLINE, EMBASE and Cochrane Library database and conducted a systematic review and meta-analysis. Thirty-six studies involving 44 655 patients with coronary artery disease(CAD) treated with clopidogrel were included, of which more than 68% had undergone percutaneous coronary intervention(PCI). The primary outcome of our interest was the recurrence of major adverse cardiovascular events(MACE) in those CAD patients. Firstly, we found that the distribution of reduced-function CYP2C19 allele varied between Westerners and Asians. Among Asians, 1 and 2 reduced-function CYP2C19 mutant allele carriers accounted for 42.5% and 10%, respectively. While among Westerners, 1 and 2 reduced-function CYP2C19 mutant allele carriers accounted for 25.5% and 2.4%, respectively. Secondly, the impact of CYP2C19 polymorphism on clinical outcomes of patients treated with clopidogrel varied with races. Among Asians, only 2 reduced-function CYP2C19 mutant allele carriers had the reduced effect of clopidogrel. And the reduced effect was significant only after the 30 th day of treatment. While among Westerners, both 1 and 2 reduced-function CYP2C19 allele carriers had the reduced effect, and it mainly occurred within the first 30 days. Thirdly, the safety of clopidogrel was almost the same among races. Reduced-function allele non-carriers had higher risk for total bleeding but did not have higher risk for major bleeding. It is suggested that CYP2C19 polymorphism affects the efficacy of clopidogrel differently among Westerners and Asians.     

牛奶中全氟烷酸与全氟磺酸前体物质超高效液相色谱-串联质谱测定方法的研究

目的建立超高效液相色谱-串联三重四级杆质谱(UPLC-MS/MS)测定牛奶基质中11种全氟烷酸与全氟磺酸前体物质的方法。方法牛奶中的目标化合物经过乙腈超声提取后,过固相萃取柱(Waters Oasis@WAX6cc)进行净化,9%氨水-甲醇洗脱。经Waters ACQUITYTMBEH C18色谱柱(50 mm×2.1 mm,1.7μm)分离,在电喷雾负离子源和多反应监测模式下进行测定,采用内标法进行定量分析。结果 11种目标化合物3个添加水平的加标回收率为66.9%~118.1%;相对标准偏差为1.1%~15.3%;检出限为0.5~10 pg/ml;定量限为1~20 pg/ml。对6份市售牛奶样本进行目标化合物的检测,4份样品中检测出2H-全氟-2-癸烯酸,浓度范围为LOD~2.69pg/ml,3份样品中检测出1H,1H,2H,2H-全氟辛基-2-磷酸盐,浓度范围为LOD~32.07 pg/ml。结论本方法简单、快速,准确度和灵敏度高,适用于牛奶基质中全氟烷酸与全氟磺酸前体物质的检测。     

计算机辅助设计个性化Medpor植入修复面部不对称畸形

目的：探讨一种修复面部不对称畸形的新方法。方法：术前应用计算机辅助设计,术中制作个性化Medpor修复体,对8例面部不对称畸形患者进行修复,术后利用成像技术对手术效果进行评估。结果：所有病例术后手术效果好,外观满意,面部不对称畸形得到了矫治。结论：应用计算机辅助设计技术,制作个性化Medpor植入体修复面部不对称畸形,手术效果满意,是一种值得推广的方法。     

骨骼肌卫星细胞研究进展

文章从骨骼肌卫星细胞的生长发育过程到自我更新再到衰老缺失、以及与生长因子的关系进行了综述,讨论了骨骼肌卫星细胞在细胞和分子水平的调节机制.为骨骼肌损伤修复提供了深入的理论依据.     

利用下颌骨延长器治疗半侧颜面短小畸形的术后评估

目的：利用图像学方法评估下颌骨延长器植入手术后延长的真实效果和理论上分析的差距,以了解其原因,并指导今后手术的术前设计。方法：选择因半侧颜面短小的患者共5例,将其真实两颏结节中间点（即正常下颌骨下缘中点）的运动轨迹和截骨线所成角度的数值和真实延长器与截骨线角度做对比。结果：发现颏点移动线路延长器方向一致性较高,最大误差7度,结果可靠。结论：在使用直线延长器进行下颌骨延长时,术前利用已有的图像学软件进行手术模拟,可以更好的控制治疗结果。     

松针提取液对小鼠移植性肿瘤及免疫功能的影响

本实验研究观察了松针提取液对小鼠移植性肿瘤Ｈｅｐｓ、Ｓ－１８０实体瘤及免疫功能的影响。结果表明：松针提取液对小鼠移植性肿瘤有一定的抑制作用，抑瘤率达４０％以上，并有保护胸腺和脾脏萎缩的作用。     

刘芳：美丽天使在人间

一路上因为有梦想，所以敢打敢拼；一路上因为有汗水，所以不轻言放弃；一路上因为有付出，所以敢于面对；一路上因为有蓝梦，所以美丽遍人间。这就是刘芳赋予蓝梦集团的气质。     

华山奖 中华美业一声铿锵

一路成长让我们铿锵有力,一路艰辛让我们无愧美业至尊。站在巨人的肩膀上,我们翘首期盼更绚烂的辉煌!2010香柏安·华山论剑·第七届中国美业领袖年会为我们提供了一个瞭望的窗口,荣誉肩上扛着的不仅仅是光环,更多的是责任,在这里我们集结荣誉的航母,驶向中华美业浪涛激流的辉煌明天!