排序方式: 共有29条查询结果,搜索用时 15 毫秒
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目的 观察蒲公英对急性创伤性脑损伤的治疗作用,并探讨该药的作用机制与超氧化物歧化酶(SOD)以及谷胱甘肽过氧化物酶(GSH-PX)的关系.方法 雄性SD大鼠48只,随机分成以下6组:正常对照组、假手术组、脑创伤组、蒲公英低剂量治疗组(LDT组)、蒲公英中剂量治疗组(MDT组)、蒲公英高剂量治疗组(HDT组),每组8只大鼠.采用Marmarou法制造大鼠重型弥漫性颅脑创伤模型,采用生物化学观察蒲公英对大鼠脑组织中的丙二醛含量(MDA)、SOD活性、和GSH-PX活性的影响.结果 与创伤对照组比较,LDT、MDT组大鼠脑组织MDA含量减少,差异有统计学意义(P<0.05);与创伤对照组比较,HDT组大鼠脑组织MDA含量明显减少,差异有统计学意义(P<0.01).与创伤对照组比较,LDT、MDT组大鼠脑组织SOD活性和GSH-PX活性升高,差异有统计学意义(P<0.05);与创伤对照组比较,HDT组大鼠脑组织SOD活性和GSH-PX活性明显升高,差异有统计学意义(P<0.01).结论 蒲公英通过增强创伤性脑损伤后SOD和GSH的活性,降低脂质过氧化的水平,从而对创伤性脑损伤具有保护作用. 相似文献
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Influencing factors for posttraumatic hydrocephalus in patients suffering from severe traumatic brain injuries 总被引:3,自引:0,他引:3
Objective: To detect the influencing factors for posttraumatic hydrocephalus in patients with severe traumatic brain injuries and provide theoretical reference for clinical treatment. Methods : Retrospective study was made on 139 patients with severe traumatic brain injuries in our hospital. The patients were divided into two groups: hydrocephalus group and non-hydrocephalus group. Single factor analysis and multiple factor analysis were used to determine the related factors and hydrocephalus. Multiple factor analysis was conducted with logistic regression. Results: Posttraumatic hydrocephalus was found in 19.42% of patients. Age ( OR=1.050, 95% CI: 1.012-1. 090 ), decompressive craniectomy ( OR =4.312, 95 %CI : 1. 127-16.503 ), subarachnoid hemorrhage ( OR = 43.421, 95 % CI : 7. 835-240. 652 ) and continuous lumbar drainage of cerebrospinal fluid ( OR =0.045, 95%CI: 0. 011-0. 175) were screened out from nine factors as the influencing factors for posttraumatic hydrocephalus. Conclusions : Risk factors for PTH are as follows: age, deeompressive eranieetomy and subaraehnoid hemorrhage (SAH). Continuous lumbar drainage of eerebrospinal fluid can greatly reduce posttraumatic hydrocephalus. 相似文献
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目的:探讨松果体区肿瘤的显微外科治疗方法及手术技巧。方法:对四川大学华西医院神经外科2000年1月至2005年4月共收治的松果体区肿瘤行Popen手术入路的32例病例进行回顾性分析。结果:全切除15例,次全切8例,大部分切除7例,部分切除2例;其中生殖细胞瘤18例,脑膜瘤4例,星型细胞瘤4例,松果体实质细胞并松果体母细胞混合瘤1例,室管膜瘤2例,未成熟畸胎瘤并生殖细胞瘤1例,2例病理报告为血管增生和变性坏死组织。门诊及电话随访至2006年4月,按GOS治疗结果分级恢复良好24例,中残4例,重残1例,植物状态1例,死亡2例,死亡率6.75%;结论:Popen入路显微外科手术治疗松果体区肿瘤,可在直视下保护好深静脉,及时处理肿瘤的供血动脉,对小脑幕下肿瘤及长入对侧肿瘤也能全切除,是一种较为理想的术式。 相似文献
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Objective: To explore the effects of hyperbaric oxygen (HBO) treatment on the neuronal apoptosis at an earlier stage and the expressions of Cytochrome C (Cyt C), Bcl-2 (B-cell lymphoma-2 family) and Bax (Bcl-2 associated X protein) in rat brain tissues after traumatic brain injury (TBI). Methods: Forty adult rats were divided into two groups, i.e. ,Group A (the rats with untreated TBI) and Group B ( rats with HBO treatment after TBI). Sections of brain tissues of these two groups were then detected at 3,6, 12,24,72 hours after TBI by immunohistochemistry and Results: HBO treatment could up-regulate the expression of Bcl-2 within 72 hours, reduce the release of Cyt C from mitochondria, attenuate the formation of dimeric Bax and alleviate the mitochondrial edema within 24 hours after TBI. Conclusions: HBO treatment can alleviate neuronal apoptosis after TBI by reducing the release of Cyt C and the dimers of Bax and up-regulating the expression of Bcl-2. 相似文献
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经Poppen入路显微手术切除松果体区肿瘤31例临床分析 总被引:2,自引:0,他引:2
背景与目的:松果体区病变位置深在,周围解剖结构复杂,直接手术切除病变是一个挑战。本研究旨在探讨松果体区肿瘤外科切除的Poppen入路及其技术要点。方法:对31例经Poppen入路切除的松果体区肿瘤进行回顾性分析,总结其临床特点、手术要点及预后。结果:肿瘤全切除26例,次全切除3例,部分切除2例,手术死亡2例;随访3个月至6年,KPS评分90分以上26例。结论:Poppen入路是治疗松果体区肿瘤较安全而有效的最佳入路之一,经脑生理间隙进入,肿瘤全切率高,手术创伤小,治疗效果好。 相似文献
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目的探讨影响重型脑创伤后脑积水形成的相关因素,为临床防治提供理论依据。方法对收治的符合条件的139例重型颅脑外伤患者进行回顾性研究,分为脑积水组和非脑积水组。对年龄、性别、受伤当时GCS评分、昏迷时间、颅内出血的部位和时间、去骨瓣减压、蛛网膜下腔出血和腰椎持续外引流与脑积水之间的关系进行单因素和Logistic逐步回归法多因素分析。结果 19.42%的患者发生了脑积水。通过Logistic逐步回归分析从9个因素中筛选出年龄(P=0.010)、去骨瓣减压(P=0.033)、蛛网膜下腔出血(P=0.000)和腰大池持续脑脊液外引流(P=0.000)为影响脑脊液发生的相关因素,其中腰大池持续脑脊液外引流为保护性因素。结论年龄增大、去骨瓣减压、蛛网膜下腔出血促使创伤后脑积水产生的重要因素,而外伤后早期行腰大池持续脑脊液外引流可明显减少脑积水的产生。 相似文献