Parkin基因启动子区-258T/G多态性与广西地区散发性帕金森病的相关性分析

Objective To investigate the association between the-258T/G polymorphism.in the pro-moter of parkin gene and the risk for sporadic parkinson's disease (SPD) in Guangxi Province, and in relationto the age of onset, of PD patients. Methods PCR-RFLP and sequence analysis were used to determine thegenotype of-258T/G polymorphism between all patients and healthy controls. Results The G allele was morecommon in patients than controls (55.20%:43.33% ,x2=6.898, P<0.05, OR=1.61, 95% CI: 1.13 ～2.30). The frequency of GG genotype was higher in patients than in controls (28.00 %: 18.33%, x2=7.159, P<0.05, OR=2.75, 95% CI : 1.31 ～ 5.77). The frequency of TG + GG genotype was higher in pa-tients than in controls (82.40%:68.33%, x2=6.551, P<0.05, OR=2.17.95%CI: 1.20 ～3.93). Afterbeing stratified by onset age, the frequencies of the G allele and GG genotype were significantly higher in pa-tients with onset age over 50 years than those in controls respectively. On the other hand, the frequency was notsignificantly different between the younger onset PD patients and the controls. Conclusion The parkin promot-er-258T/G polymorphism might be a risk factor for PD in Guangxi Province, and the G allele was increasedwith increasing age.     

急性脑血管病伴发糖尿病高渗性昏迷21例临床分析

糖尿病高渗性昏迷又称高渗性非酮症性糖尿病昏迷 ,诱发因素较多 ,脑血管病为其诱发因素之一 ,,尤以重症脑血管病意识障碍、并发肺部感染、使用甘露醇、速尿后等多见。本病若不及时诊治 ,病死率极高。现将我院 1997年 1月至 2 0 0 0年 1月住院的 2 1例急性脑血管病伴发糖尿病高渗性昏迷报道如下。1　临床资料1.1　一般资料 :2 1例中男 13例 ,女 8例 ;年龄 5 1～ 82岁 ,平均 6 7岁。符合脑血管病诊断要点 [1 ] ,并经头颅 CT或 MRI证实 :脑出血 6例 (其中丘脑出血 1例 ,出血量为 10 ml;基底节区出血 4例 ,出血量为 10～ 5 0 m l;脑叶出血 1例…     

Parkin基因启动子区-258T/G多态性与广西地区散发性帕金森病的相关性分析

Objective To investigate the association between the-258T/G polymorphism.in the pro-moter of parkin gene and the risk for sporadic parkinson's disease (SPD) in Guangxi Province, and in relationto the age of onset, of PD patients. Methods PCR-RFLP and sequence analysis were used to determine thegenotype of-258T/G polymorphism between all patients and healthy controls. Results The G allele was morecommon in patients than controls (55.20%:43.33% ,x2=6.898, P<0.05, OR=1.61, 95% CI: 1.13 ～2.30). The frequency of GG genotype was higher in patients than in controls (28.00 %: 18.33%, x2=7.159, P<0.05, OR=2.75, 95% CI : 1.31 ～ 5.77). The frequency of TG + GG genotype was higher in pa-tients than in controls (82.40%:68.33%, x2=6.551, P<0.05, OR=2.17.95%CI: 1.20 ～3.93). Afterbeing stratified by onset age, the frequencies of the G allele and GG genotype were significantly higher in pa-tients with onset age over 50 years than those in controls respectively. On the other hand, the frequency was notsignificantly different between the younger onset PD patients and the controls. Conclusion The parkin promot-er-258T/G polymorphism might be a risk factor for PD in Guangxi Province, and the G allele was increasedwith increasing age.     

颈动脉系统TIA病人血液流变学和脑血流速度的改变

目的　探讨颈内动脉系统短暂性脑缺血发作 (TIA)病人的血液流变学和脑血流速度的改变及其临床意义。方法　 6 0例颈内动脉系统 TIA病人均在末次发作后 2 4h内进行血液流变学和脑血流速度测定。结果　 1病人组的全血粘度、血浆粘度、红细胞压积及红细胞聚集性各指标均明显增高 ,与正常对照组比较有显著性差异 ;2绝大多数患者脑动脉有严重狭窄或痉挛存在 ,从而引起脑血流速度的改变。结论　血液粘度增高、颅内动脉的狭窄或痉挛引起的血流动力学障碍是导致颈内动脉系统短暂性脑缺血发作的两种机理     

干细胞移植治疗帕金森病的研究进展

帕金森病(PD)是一种常见的神经系统变性疾病,其病理改变的最大特点是病变只侵犯中脑的多巴胺(DA)能神经元,导致纹状体内DA的减少从而引起运动迟缓,静止性震颤,肌肉强直等锥体外系症状。自20世纪90年代初开始应用胎儿脑组织移植治疗PD以来,已有大约350例患者接受了胎脑移植手术[     

脑出血与脑梗死患者血脂成分及血浆纤维蛋白原含量的变化及其意义

脑血管疾病在我国居于死亡原因的第 3位 ,许多研究表明其主要危险因素是动脉粥样硬化 (As) ,在形成 As的各种因素中血脂代谢异常及血浆纤维蛋白原 (Fig)含量增高起重要作用。本文通过对脑出血 17例 ,脑梗死 2 7例及对照组 2 1例的血脂成分及 Fig含量的检测 ,探讨血脂 ,载脂蛋白及 Fig与脑血管病的关系 ,现报告如下。1　对象和方法1.1　对象 :44例脑血管病病人均为 1999的 9月至 2 0 0 0年 6月本院住院病人 ,均为发病后 72 h内入院的病例 ,分为脑出血组 17例 ,男 10例 ,女 7例 ,年龄 39～ 72岁 ,平均 (6 1.5± 6 .2 )岁。脑梗死组 2 7例 ,…     

影响多巴胺能神经元体内外分化的因素

帕金森病是神经系统变性疾病,以黑质多巴胺能神经元变性缺失为特征。现在,人们通过对多巴胺能神经元体内外分化条件的研究,获得利于其分化和存活的最佳条件,为帕金森病的细胞替代治疗提供充足的多巴胺能神经元。本文对体内外神经干细胞向多巴胺能神经元诱导分化的影响因素做一综述。     

微栓子的TCD检测进展

本文回顾了经颅多谱勒超声实时监测脑动脉血流中微栓子的基本原理，并对其基础与临床研究的现状作一综述。